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Skin Tumor Promotion: A Comparative Study of Several Stocks and Strains of Mice

  • Chapter
Organ and Species Specificity in Chemical Carcinogenesis

Part of the book series: Basic Life Sciences ((BLSC))

Abstract

Topical application of some chemical carcinogens will induce skin tumors on mice. In general, most chemical carcinogens have to be given repeatedly to induce a large number of tumors (complete carcinogenesis). Skin tumors also can be induced by the sequential application of a single subthreshold dose of a carcinogen (initiation phase) followed by repeated treatment with a noncarcinogenic promoter (promotion phase). This second procedure employing initiation and promotion is referred to as two-stage carcinogenesis.

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Author information

Authors and Affiliations

  1. Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, 37830, USA

    John Reiners Jr., Kowetha Davidson, Kay Nelson, Mark Mamrack & Thomas Slaga

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  1. John Reiners Jr.
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  2. Kowetha Davidson
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  3. Kay Nelson
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  4. Mark Mamrack
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  5. Thomas Slaga
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Editor information

Editors and Affiliations

  1. U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA

    Robert Langenbach  & Stephen Nesnow  & 

  2. National Cancer Institute, Bethesda, Maryland, USA

    Jerry M. Rice

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© 1983 Plenum Press, New York

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Reiners, J., Davidson, K., Nelson, K., Mamrack, M., Slaga, T. (1983). Skin Tumor Promotion: A Comparative Study of Several Stocks and Strains of Mice. In: Langenbach, R., Nesnow, S., Rice, J.M. (eds) Organ and Species Specificity in Chemical Carcinogenesis. Basic Life Sciences. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4400-1_9

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  • DOI: https://doi.org/10.1007/978-1-4684-4400-1_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4402-5

  • Online ISBN: 978-1-4684-4400-1

  • eBook Packages: Springer Book Archive

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