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Genetics of the Immune Response pp 91–109Cite as

Immunological Surveillance: T Cell Repertoire and the Biological Function of MHC Antigens

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Part of the book series: Nobel Foundation Symposia Published by Plenum ((NOFS,volume 55))

Abstract

Ten years ago we had no clear idea of the biological role of the major histocompatibility complex (MHC), though many people were trying to deal with the issue intellectually.1–4 The phenomenon of alloreactivity dominated both experiments and concepts. Considerable effort had been put into the study of graft rejection and the strong transplantation antigens. Could it be that these extremely potent immune responses, and the glycoproteins at which they were directed, had no physiological function other than the elimination of transplanted tissues? Was alloreactivity a phylogenetic remnant of the need to avoid mutual parasitism in primitive life forms, now used in complex vertebrates to limit the emergence of spontaneous tumors? Such thinking led to Burnet’s formulation of the immunological surveillance concept.5

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  1. Department of Experimental Pathology, The John Curtin School of Medical Research, Canberra, A.C.T., 2601, Australia

    Peter C. Doherty

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Doherty, P.C. (1983). Immunological Surveillance: T Cell Repertoire and the Biological Function of MHC Antigens. In: Möller, E., Möller, G. (eds) Genetics of the Immune Response. Nobel Foundation Symposia Published by Plenum, vol 55. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4469-8_4

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