Abstract
The spontaneously hypertensive rat (SHR) exhibits a variety of abnormalities in its handling of calcium (1–3) and phosphorus (4,5) and calcium supplementation has been shown to reduce its arterial blood pressure (3,6). The relationship between disturbed calcium and phosphorus metabolism and hypertension, however, remains unclear. Several investigators have studied intestinal calcium transport in the SHR and have reported increased (7,8), unchanged (9) or decreased (10) absorption compared with its genetic control, the WistarKyoto rat (WKY). In these studies, Ca2+ absorption has been determined by means of intestinal perfusion (10) or in situ uptake (8) in vivo,everted gut sacs in vitro (7,9,10), or by balance studies (8). The variety of experimental systems employed may in part explain the diversity in these findings. We have recently addressed this issue utilising the modified Ussing apparatus (11) which permits continuous monitoring of tissue viability and the study of active intestinal calcium transport under electrically controlled conditions.
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© 1986 Plenum Press, New York
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Lucas, P.A., Drueke, T., Lacour, B., Brown, R.C., McCarron, D.A. (1986). Impaired Intestinal Calcium Transport in the Spontaneously Hypertensive Rat. In: Massry, S.G., Olmer, M., Ritz, E. (eds) Phosphate and Mineral Homeostasis. Advances in Experimental Medicine and Biology, vol 208. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5206-8_30
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DOI: https://doi.org/10.1007/978-1-4684-5206-8_30
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