Abstract
Endothelium is comprised of heterogeneous cell populations residing in a variety of vascular beds. The endothelial cells resident in these diverse vascular beds or regions exhibit a broad range of diversity in their functions and appearances in addition to their shared common features such as non-thrombogenicity, polarity, and transport functions. Response to injury (neovascularization) is a response common to all endothelial cell populations, yet the responses vary depending on whether the endothelial cells are derived from large vessels or the microvasculature. Another factor thought to play an important role in the modulation of endothelial cell behavior in response to injury is the extracellular matrix. Large-vessel endothelial cells respond to injury by sheet migration/proliferation until the defect is covered. Evidence has been accrued supporting the concept that the underlying matrix determines, in part, the migration and proliferation rates, possibly via modulating cytoskeletal organization of the cells. In addition, the continual synthesis and secretion of matrix components by the responding cells appear to be crucial in the response to injury. Although microvascular endothelial cells respond to injury by migration and proliferation as do the large vessel endothelial cells, they migrate through interstitial tissue and ultimately form capillaries. Recent evidence has demonstrated that matrix composition can affect proliferation rate, matrix synthesis, and multicellular organization during the neovascularization process. In addition, matrix organization appears to influence differentiation of microvascular endothelial cells, specifically the ability of selected endothelial cell populations to form fenestrations. Thus, matrix composition and organization appear to play significant roles in orchestrating the growth and differentiation of endothelial cells during the highly integrated series of responses known as neovascularization.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bissell, M. L., Hall, H. G., and Parry, G., 1982, How does the extracellular matrix direct gene expression? J. Theor. Biol. 99:31–68.
Fishman, A. P. (ed.), 1982, Endothelium ,New York Academy of Sciences, New York.
Fleischmajer, R., Olsen, B. R., and Kuhn, K. (eds.), 1986, Biology, Chemistry and Pathology of Collagen ,New York Academy of Sciences, New York.
Form, D. M., and Madri, J. A., 1985, Proliferation of microvascular endothelial cells in vitro Modulation by extracellular matrix, Fed. Proc. 44:7309.
Form, D. J., Pratt, B. M., and Madri, J. A., 1986, Endothelial cell proliferation during angiogenesis: In vitro modulation by basement membrane components. Lab. Invest. 55:521–530.
Gotlieb, A. I., Spector, W., Wong, M. K. K., and Lacey, C., 1984a, In vitro reendothelialization: Microfilament bundle reorganization in migrating porcine endothelial cells, Arteriosclerosis 4:91–96.
Gotlieb, A. I., Subrahmanyan, L., and Kalnins, V. I., 1984b, Microtubule-organizing centers and cell migration: Effect of inhibition of migration and microtubule disruption in endothelial cells, J. Cell Biol. 96:1266–1272.
Herman, I. M., Pollard, T. D., and Wong, A. J., 1982, Contractile proteins in endothelial cells, Ann. N.Y. Acad. Sci. 401:50–60.
Ingber, D. E., Madri, J. A., and Jamieson, J. D., 1981, Role of basal lamina in neoplastic disorganization of tissue architecture, Proc. Natl. Acad. Sci. U.S.A. 78:3901–3905.
Ingber, D. E., Madri, J. A., and Jamieson, J. D., 1985, Neoplastic disorganization of pancreatic epithelial cell-cell relations, Am. J. Pathol. 121:248–260.
Ingber, D. E., Madri, J. A., and Jamieson, J. D., 1986, Basement membrane as a spacial organizer of polarized epithelia: Exogenous basement membrane reorients pancreatic epithelial tumor cells, Am. J. Pathol. 122:129–139.
Kurkinen, M., Taylor, A., Garrels, A., and Hogan, B. M. L., 1984, Cell-surface-associated proteins which bind native type IV collagen and gelatin, J. Biol. Chem. 259:5915–5922.
Leto, T. L., Pratt, B. M., and Madri, J. A., 1986, Mechanisms of cytoskeletal regulation: Modulation of aortic endothelial cell protein band 4.1 by extracellular matrix, J. Cell Physiol. 127:423–431.
Lwebuga-Mukasa, J., Thulin, G., Madri, J. A., Barrett, C., and Warshaw, J., 1984, An acellular human amnion membrane model for in vitro culture of type II pneumocytes: The role of the basement membrane on cell morphology and function, J. Cell. Physiol. 121:215–225.
Lwebuga-Mukasa, J., Ingbar, D. H., and Madri, J. A., 1986, Repopulation of a human alveolar matrix by adult rat type II pneumocytes in vitro, Exp. Cell Res. 162:423–435.
Madri, J. A., 1982, Endothelial cell-matrix interactions in hemostasis, in: Progress in Hemostasis and Thrombosis ,Vol. 6 (T. H. Spaet, ed.), Grune & Stratton, New York, pp. 1–24.
Madri, J. A., and Stenn, K. S., 1982, Aortic endothelial cell migration. I. Matrix requirements and composition, Am. J. Pathol. 106:180–186.
Madri, J. A., and Pratt, B. M., 1986, Endothelial cell-matrix interactions: In vitro models of angi-ogenesis, J. Histochem. Cytochem. 34:85–91.
Madri, J. A., and Pratt, B. M., 1987, Angiogenesis, in: The Molecular and Cellular Biology of Wound Repair ,(R. A. Clark and P. Henson, eds.), Plenum Press, New York (in press).
Madri, J. A., and Williams, S. K., 1983, Capillary endothelial cell cultures: Phenotypic modulation by matrix components, J. Cell Biol. 97:153–165.
Montesano, R. L., Orci, L., and Vassali, P., 1983, In vitro rapid organization of endothelial cells into capillary-like networks is promoted by collagen matrices, J. Cell Biol. 97:1648–1652.
Palotie, A., Tryggvason, K., Peltonen, L., and Seppa, H., 1983, Components of the subendothelial aorta basement membrane. Immunohistochemical localization and role in cell attachment, Lab. Invest. 49:362–372.
Pratt, B. M., Harris, A. S., Morrow, J. S., and Madri, J. A., 1984, Mechanisms of cytoskeletal regulation: Modulation of aortic endothelial cell spectrin by the extracellular matrix. Am. J. Pathol. 117:348–354.
Pratt, B. M., Form, D., and Madri, J. A., 1986, Endothelial cell-extracellular matrix interactions, Ann. N.Y. Acad. Sci. 460:274–288.
Pytela, R., Pierschbacher, M. D., and Ruoslahti, E., 1985, Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptor Cell 40:191–198.
von der Mark, K., and Kuhl, U., 1985, Laminin and its receptor, Biochim. Biophys. Acta 823:147–160.
Yannariello-Brown, J., and Madri, J. A., 1985, Aortic endothelial cells synthesize specific binding proteins for laminin and type IV collagen, J. Cell Biol. 101:333a.
Yannariello-Brown, J., Tchao, N., Liotta, L., and Madri, J. A., 1985, Co-distribution of the laminin receptor with actin microfilaments in permeablized aortic and microvascular endothelial cells, J. Cell Biol. 101:333a.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Plenum Press, New York
About this chapter
Cite this chapter
Madri, J.A. (1987). The Extracellular Matrix as a Modulator of Angiogenesis. In: Gallo, L.L. (eds) Cardiovascular Disease. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5296-9_21
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5296-9_21
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5298-3
Online ISBN: 978-1-4684-5296-9
eBook Packages: Springer Book Archive