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Ice Crystal Growth in Aqueous Solutions

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The Biophysics of Organ Cryopreservation

Part of the book series: NATO ASI Series ((NSSA,volume 147))

Abstract

Causes and mechanisms of cryo-injury are generally multifacetted and may be of thermal, mechanical, chemical and electrical nature. For understanding the effects of ice formation on biological cells it is necessary to first obtain an exact knowledge of the ice formation process itself. If the crystallization of ice cannot be totally avoided or circumvented as described in other chapters of this volume, one has to consider its growth habits and kinetics, i.e. the morphology and the propagation of the ice-liquid interface. From a cryobiological standpoint, it is particularly important to study the “secondary effects” of ice formation, i.e. the changes induced in the solution on the liquid side of the solidification front. The solid side, i.e. the structure and the properties of the ice crystals themselves, on the other hand are less relevant with respect to freezing injury: biological cells or subcellular structures are first in the liquid where they experience changes ahead of the approaching ice front. However, both solid and liquid phase interact and influence each other. The growth habit and the properties of the ice crystal depend on the conditions in the “mother solution”, and vice versa.

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Author information

Authors and Affiliations

  1. Helmholtz-Institut für Biomedizinische Technik, RWTH Aachen, D-5100, Aachen, West Germany

    Christoph Körber & Günter Rau

Authors
  1. Christoph Körber
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  2. Günter Rau
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Editor information

Editors and Affiliations

  1. MRC Medical Cryobiology Group, Cambridge University, Cambridge, UK

    David E. Pegg

  2. Medical College of Georgia, Augusta, Georgia, USA

    Armand M. Karow Jr.

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© 1987 Plenum Press, New York

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Körber, C., Rau, G. (1987). Ice Crystal Growth in Aqueous Solutions. In: Pegg, D.E., Karow, A.M. (eds) The Biophysics of Organ Cryopreservation. NATO ASI Series, vol 147. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5469-7_10

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  • DOI: https://doi.org/10.1007/978-1-4684-5469-7_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5471-0

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