Abstract
Aging and death are universal phenomena. Aging is a progressive sequence of age-related, widespread, more-or-less common changes observed in every individual of a given species. These sequential changes are associated with an ever-increasing likelihood of disease and death, beginning at a minimum early in life and increasing until all members of the species are dead by a characteristic age, the maximum life span.
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References
D. Harman, The aging process, Chem. and Engineering News. 65, No. 17:2 (1987).
D. Harman, Aging: A theory based on free radical and radiation chemistry, J. Gerontol. 11:298 (1956).
D. Harman, Role of free radicals in mutation, cancer, aging, and the maintenance of life, Rad. Res. 16:753 (1962).
D. Harman, The aging process, Proc. Natl. Acad. Sci. USA. 78:7124 (1981).
D. Harman, Free radical theory of aging: Role of free radicals in the origination and evolution of life, aging, and disease process, in “Free Radicals, Aging and Degenerative Diseases,” J. E. Johnson Jr., R. Walford, D. Harman, and J. Miquel, eds., Alan R. Liss, New York (1986).
G. W. Casarett, Similarities and contrasts between radiation and time pathology, in: “Advances in Gerontology Research,” G. L. Strehler, ed., Claredon Press, Oxford (1964).
P. J. Lindrop and J. Rotblat, Long term effects of a single whole-body exposure of mice to ionizing radiation, Proc. Roy. Soc. (B) 154:332–349, 350–368 (1961).
D. Harman, Free radical theory of aging: Consequences of mitochondrial aging, Age 6:86 (1983).
D. Harman and D. E. Eddy, Free radical theory of aging: Beneficial effect of adding antioxidants to the maternal mouse diet on life span of offspring; possible explanation of the sex difference in longevity, Age 2:109 (1979).
D. Harman, Free radical theory of aging: Beneficial effect of antioxidants on the life span of male NZB mice: Role of free radical reactions in the deterioration of the immune system with age and in the pathogenesis of systemic lupus erythematosus, Age 3:64 (1980).
D. Harman, Free radical theory of aging: The “free radical” diseases, Age 7:111 (1984).
R. R. Kohn, Cause of death in very old people, JAMA 247:2793 (1982).
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© 1988 Plenum Press, New York
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Harman, D. (1988). The Aging Process. In: Simic, M.G., Taylor, K.A., Ward, J.F., von Sonntag, C. (eds) Oxygen Radicals in Biology and Medicine. Basic Life Sciences, vol 49. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5568-7_175
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DOI: https://doi.org/10.1007/978-1-4684-5568-7_175
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5570-0
Online ISBN: 978-1-4684-5568-7
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