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Detection of Lipid Peroxidation Products in Lipids and Tissues by Gas Chromatography-Mass Spectrometry

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Oxygen Radicals in Biology and Medicine

Part of the book series: Basic Life Sciences ((BLSC,volume 49))

Abstract

Formation of oxygen radicals and lipid peroxidation have been suggested to play a key role in various types of tissue degeneration and pathology such as heart disease, aging, cancer, and retinal degeneration.1,2 Membrane phospholipids and triglycerides contain the principal deposits of unsaturated fatty acids and are thought to be the primary sites of the lipid peroxidation process. The oxidation of membrane phospholipids has been hypothesized to cause an increase in the permeability of cell membranes and/or to inhibit membrane ion pumps and to lead to cell death. This loss of membrane barrier function is thought to lead to edema, disturbances in electrolyte balance, and elevation of intracellular calcium which contributes to the malfunctioning of cells.

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Author information

Authors and Affiliations

  1. Department of Biochemistry, MF University of Nijmegen, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands

    F. J. G. M. van Kuijk

  2. Life Sciences Division, SRI International, Menlo Park, California, 94025, USA

    D. W. Thomas & R. J. Stephens

  3. Chemistry Department, Montana State University, Bozeman, Montana, 59717, USA

    E. A. Dratz

Authors
  1. F. J. G. M. van Kuijk
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  2. D. W. Thomas
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  3. R. J. Stephens
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  4. E. A. Dratz
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Editor information

Editors and Affiliations

  1. National Bureau of Standards, Gaithersburg, Maryland, USA

    Michael G. Simic

  2. International Life Sciences Institute, Washington, D.C., USA

    Karen A. Taylor

  3. Univesity of California, San Diego, La Jolla, California, USA

    John F. Ward

  4. Max-Planck-Institut für Strahlenchemie, Mülheim a.d. Ruhr, Federal Republic of Germany

    Clemens von Sonntag

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© 1988 Plenum Press, New York

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van Kuijk, F.J.G.M., Thomas, D.W., Stephens, R.J., Dratz, E.A. (1988). Detection of Lipid Peroxidation Products in Lipids and Tissues by Gas Chromatography-Mass Spectrometry. In: Simic, M.G., Taylor, K.A., Ward, J.F., von Sonntag, C. (eds) Oxygen Radicals in Biology and Medicine. Basic Life Sciences, vol 49. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5568-7_26

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  • DOI: https://doi.org/10.1007/978-1-4684-5568-7_26

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5570-0

  • Online ISBN: 978-1-4684-5568-7

  • eBook Packages: Springer Book Archive

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