Abstract
This chapter briefly discusses two viruses that infect diverse species of animals but that share an important similarity in that both viruses are lymphotropic and cause profound immunosuppression in their respective hosts. Infectious bursal disease (IBD) of chickens, also referred to as Gumboro disease, is an eco nomically important disease of commercial chickens. In unprotected chickens, the IBD virus (IBDV) rapidly destroys the lymphocyte population in the bursa of Fabricius, the principal organ that regulates humoral immunity in the chicken. Continued economic loss due to IBD in the field and recent general interest in viral immunosuppression have stimulated renewed efforts in understanding the characteristics of the immunosuppressive effects of this disease. The mouse hepatitis virus (MHV), also a common infection in laboratory mouse colonies, causes a debilitating disease accompanied by severe immunosuppression. The influence of MHV on immune functions of the host seems to be related to a close interaction between virus particles and host lymphoid cells.
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Keywords
- Newcastle Disease
- Infectious Bronchitis Virus
- Carbonyl Iron
- Infectious Bursal Disease Virus
- Mixed Lymphocyte Reaction
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Sharma, J.M., Dupuy, J.M., Lamontagne, L. (1989). Immunosuppression by Avian Infectious Bursal Disease Virus and Mouse Hepatitis Virus. In: Specter, S., Bendinelli, M., Friedman, H. (eds) Virus-Induced Immunosuppression. Infectious agents and pathogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5583-0_11
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