Abstract
In alcohol toxicity, a lot of data point to genetic factors associated with environmental factors. These genetic factors can intervene at different levels : genetic variability in the distribution of polymorphic alcohol and aldehyde dehydrogenase isozymes (Bosron, et al., 1988) could play a role in determining individual difference in ethanol metabolism and toxicity. In the future, other polymorphisms in alcohol metabolism may be described. Polymorphism is also to be considered in detoxication and/or target organ metabolism (as collagen polymorphism in alcoholic cirrhosis)(Weiner, et al., 1988).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Agarwal, D.P., Goedde, H.W.,1989, Enzymology of alcohol degradation. In Alcoholism Biomedical and Genetic Aspects ,Goedde, H.W. and Agarwal, D.P. eds, pp. 3–20. Pergamon Press, New York.
Bosron, W.F., Lumeng, L., Li, T.K., 1988, Genetic polymorphism of enzymes of alcohol metabolism and susceptibility to alcoholic liver disease. Molec. Aspects Med. ,10 : 147–158.
Coutelle, C., Fleury, B., Couzigou, P., Poupon, R.E., Nalpas, B., Iron, A., Higueret, D., Saric, J., Masson, B., Béraud, C., Cassaigne, A., 1989, Distribution of ß and isozymes of hepatic alcohol dehydrogenase (ADH) in France (Abstract), Alcohol Alcoholism ,24 : 369.
Edwards, J.A., Price Evans, D.A., 1967, Ethanol metabolism in subjects possessing typical and atypical liver alcohol dehydrogenase, Clin. Pharmacol. Ther. ,8 : 824–829.
Gennari, K., Wermuth, B., Muellener, D.,Ehrig, E., and von Wartburg, J.P., 1988, Genotyping of human class I alcohol dehydrogenase. Analysis of enzymatically amplified DNA with allele-specific oligonucleotides, FEBS Letters , 228: 305–309.
Goedde, H.W., Agarwal, D.P., 1989, Acetaldehyde metabolism : genetic variation and physiological implications, In Alcoholism Biomedical and Genetic Aspects ,Goedde, H.W. and Agarwal, D.P. eds, pp. 21–56. Pergamon Press, New York.
Groppi, A., Bégueret, J., Iron, A., Advanced methods in the genotype determination of the human alcohol dehydrogenase at the ADH 2 and ADH 3 loci using directed mutagenesis by P.C.R., Clin. Chenu ,in press.
Hrubec, Z., Ommen, G.S.,1981, Evidence of genetic predisposition to alcoholic cirrhosis and psychosis : twin concordances for alcoholism and its biological end-points by zygotisis among male veterans. Alcoholism Clin. Exp. Res. ,5 : 207–215.
Iron, A., Groppi, A., Fleury, B., Couzigou, P., Bégueret, J., Cassaigne, A., 1989, A procedure for complete genotyping human class I alcohol dehydrogenase (ADH) with the polymerase chain reaction (P.C.R.) on a micro-blood sample (Abstract). Alcohol Alcoholism , 24 : 377.
Kopun, M., Propping, P., 1977, The kinetics of ethanol absorption and elimination in twins and supplementary repetitive experiments in singleton subjects, Eur. J. Clin. Pharmacol.,11: 337–344
Martin, N.G., PerlJ., Oakeshott, J.G., Gibson, J.B., Starmer, G.A., Wilks, A.V., 1985, A twin study of ethanol metabolism , Behav. Genet. ,15 : 93–109.
Sarles, H., Bernard, J.P., Gullo, L., 1990, Pathogenesis of chronic pancreatitis, Gut ,31 : 629–632.
Shibuya, A. ,Yoshida, A., 1988, Genotypes of alcohol metabolizing enzymes in Japanese with alcohol liver diseases : a strong association of the usual Caucasian-type aldehyde dehydrogenase gene (ALDH21) with the disease,Am. J. Hum. Genet. ,43: 744–748.
Weiner, F.R., Eskreis, D.S., Compton, K.V., Orrego, H., Zern, M.A., 1988, Haplotype analysis of a type I collagen genetic and its association with alcoholic cirrhosis in man, Molec.Aspects Med. ,10 : 159– 168.
Xu, Y., Carr, L.G., ßosron, W.F., Li, T.K., Edenberg, H.J., 1988, Genotyping of human alcohol dehydrogenases at the ADH2 and ADH3 loci following sequence amplification, Genomics , 2 209– 214.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Plenum Press, New York
About this chapter
Cite this chapter
Couzigou, P. et al. (1990). Role of Alcohol Dehydrogenase Polymorphism in Ethanol Metabolism and Alcohol-Related Diseases. In: Weiner, H., Wermuth, B., Crabb, D.W. (eds) Enzymology and Molecular Biology of Carbonyl Metabolism 3. Advances in Experimental Medicine and Biology, vol 284. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5901-2_28
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5901-2_28
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5903-6
Online ISBN: 978-1-4684-5901-2
eBook Packages: Springer Book Archive