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What is Meant by Overproduction of Apo B-Containing Lipoproteins?

  • Chapter
Hypercholesterolemia, Hypocholesterolemia, Hypertriglyceridemia, in Vivo Kinetics

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 285))

Abstract

Several mechanisms have been implicated in the development of hyperlipidemia. These include reduced activity of receptors for low density lipoproteins (LDL), deficiencies in lipoprotein lipase (LPL), abnormalities in the primary structures of apolipoproteins C-II, E, and B-100, and overproduction of lipoproteins containing apolipoprotein B-100 (apo B) . All of these except the last are well documented. On the other hand, many researchers believe that overproduction of apo B-containing lipoproteins is one of the more common causes of hyperlipidemia. Therefore, it is worthwhile to consider the evidence for the existence of lipoprotein overproduction as a cause for hyperlipidemia. The present paper will examine the available data related to this question.

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Author information

Authors and Affiliations

  1. Center for Human Nutrition Departments of Clinical Nutrition Biochemistry and Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas, 75235-9052, USA

    Scott M. Grundy & Gloria Lena Vega

Authors
  1. Scott M. Grundy
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  2. Gloria Lena Vega
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Editor information

Editors and Affiliations

  1. Research Foundation on Atherosclerosis, B-1000, Brussels, Belgium

    Claude L. Malmendier

  2. Lipoprotein and Atherosclerosis Resaerch Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, 73104, USA

    P. Alaupovic

  3. Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA

    H. Bryan Brewer Jr.

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© 1990 Plenum Press, New York

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Grundy, S.M., Vega, G.L. (1990). What is Meant by Overproduction of Apo B-Containing Lipoproteins?. In: Malmendier, C.L., Alaupovic, P., Brewer, H.B. (eds) Hypercholesterolemia, Hypocholesterolemia, Hypertriglyceridemia, in Vivo Kinetics. Advances in Experimental Medicine and Biology, vol 285. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5904-3_26

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  • DOI: https://doi.org/10.1007/978-1-4684-5904-3_26

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5906-7

  • Online ISBN: 978-1-4684-5904-3

  • eBook Packages: Springer Book Archive

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