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Mescaline and Phenothiazines: Recent Studies on Sub-cellular Localization and Effects upon Membranes

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Protein Metabolism of the Nervous System

Abstract

Here we summarize some recent investigations of possible modes of action of two types of psychotropic drugs: psychotomimetics and phenothiazines, using studies with mescaline and chlorpromazine (CPZ), respectively, as examples. General reviews of their pharmacology have appeared, covering work done prior to 1962,(1) with reference to specific classes of psychotomimetic(2–4) or neuroleptic drugs,(5,6) but reviews of effects on biological membranes are less frequent.(7–13) [For reasons described below we have restricted our review of the effects of these drugs on subcellular organelles and the potential effects on central nervous system (CNS) protein metabolism to systems containing 50 µM or less psychotropic drug.]

Enthusiastic technical assistance was provided by S. Orenstein, and by B. Horn, and A. Sussman, Student Trainees supported by the N. Y. State Dept. of Mental Hygiene Summer Employment Program and by the Research Foundation for Mental Hygiene, Inc., Albany, respectively, during July and August, 1968.

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References

  1. S. Eiduson, E. Geller, A. Yuwiler, B. T. Eiduson, “Biochemistry and Behavior,” D. Van Nostrand Company, Princeton, New Jersey (1964).

    Google Scholar 

  2. L. G. Abood, in: “Drugs Affecting the Central Nervous System,” (A. Burger, ed.), Vol. 2, pp. 127–167, Marcel Dekker, New York (1968).

    Google Scholar 

  3. S. Cohen, Ann. Rev. Pharmacol. 7, 301–318 (1967).

    Article  PubMed  CAS  Google Scholar 

  4. A. Hofmann, in: “Drugs Affecting the Central Nervous System,” (A. Burger, ed.), Vol. 2, pp. 169–235, Marcel Dekker, New York (1968).

    Google Scholar 

  5. E. F. Domino, R. D. Hudson, G. Zografi, in: “Drugs Affecting the Central Nervous System,” (A. Burger, ed.), Vol. 2, pp. 327–397, Marcel Dekker, New York (1968).

    Google Scholar 

  6. M. Gordon, Med. Chem., Ser. Monogr. 4 (I1), 1–198 (1967).

    Google Scholar 

  7. P. S. Guth, M. A. Spirtes, Int. Rev. Neurobiol. 7, 231–278 (1964).

    Article  PubMed  CAS  Google Scholar 

  8. H. Medina, A. Dmytraczenko,, M. Bacila, Biochem. Pharmacol. 13, 461–467 (1964).

    Article  PubMed  CAS  Google Scholar 

  9. D. N. Teller, Kinetics of binding and inhibition of enzymatic activity by phenothiazine compounds, unpublished doctoral dissertation, New York University, 1964.

    Google Scholar 

  10. B. M. Bloom, Ann. Rep. Med. Chem. 1965, 236–246.

    Google Scholar 

  11. P. M. Seeman, The erythrocyte as a model for studying membrane stabilization by tranquilizers, anesthetics, and steroids, unpublished doctoral dissertation, The Rockefeller University, 1966.

    Google Scholar 

  12. B. M. Bloom, Ann. Rep. Med. Chem. 1966, 227–236.

    Google Scholar 

  13. H. C. B. Denber, Intracellular localization of psychotomimetic and psychotropic drugs, unpublished doctoral dissertation, New York University, 1967.

    Google Scholar 

  14. S. Symchowicz, W. D. Peckham, C. A. Korduba, P. L. Perlman, Biochem. Pharmacol. 11, 499–506 (1962).

    Article  CAS  Google Scholar 

  15. S. Symchowicz, W. D. Peckham, M. Eisler, P. L. Perlman, Biochem. Pharmacol. 11, 417–422 (1962).

    Article  CAS  Google Scholar 

  16. K. Zehnder, F. Kalberer, W. Kreis, J. Rutschmann, Biochem. Pharmacol. 11, 535–550 (1962).

    Article  PubMed  CAS  Google Scholar 

  17. F. Kalberer, W. Kreis, J. Rutschmann, Biochem. Pharmacol. 11, 261–269 (1962).

    Article  PubMed  CAS  Google Scholar 

  18. H. C. B. Denber, D. N. Teller, Agressologie 9, 127–136 (1968).

    PubMed  CAS  Google Scholar 

  19. R. P. Maickel, M. C. Gerald, D. M. Warburton, and M. A. Mahju, Agressologie 9, 373–377 (1968).

    PubMed  CAS  Google Scholar 

  20. D. N. Teller, H. C. B. Denber, Dis. Nerv. Syst. 30, 15–18 (1969).

    PubMed  Google Scholar 

  21. I. S. Forrest, A. G. Bolt, M. T. Serra, Biochem. Pharmacol. 17, 2061–2070 (1968).

    Article  PubMed  CAS  Google Scholar 

  22. S. H. Curry, Agressologie 9, 115–121 (1968).

    PubMed  CAS  Google Scholar 

  23. G. Steinecker, H. Schirardin, P. Metais, Ann. Pharm. Fr. 25, 315–323 (1967).

    PubMed  CAS  Google Scholar 

  24. J. B. Appel, D. X. Freedman, Biochem. Pharmacol. 13, 861–869 (1964).

    Article  PubMed  CAS  Google Scholar 

  25. H. K. Martin, Int. J. Neuropsychiat. 3, 66–71 (1967).

    Google Scholar 

  26. C. Laville, J. Margarit, Pathol. Biol. Semaine Hôp. 13, 762–766 (1965).

    CAS  Google Scholar 

  27. H. C. B. Denber, S. Merlis, Psychiat. Quart. 28, 635–640 (1954).

    Article  Google Scholar 

  28. H. C. B. Denber, S. Merlis, J. Nerv. Ment. Dis. 122, 463–469 (1955).

    Article  PubMed  CAS  Google Scholar 

  29. S. Merlis, H. C. B. Denber, J. Nerv. Ment. Dis. 123, 542–545 (1956).

    Article  PubMed  CAS  Google Scholar 

  30. H. C. B. Denber, Psychiat. Quart. 35, 18–48 (1961).

    Article  PubMed  CAS  Google Scholar 

  31. P. Rajotte, H. C. B. Denber, D. Kauffman, in: “Recent Advances in Biological Psychiatry” (J. Wortis, ed.), Vol. 4, pp. 278–286, Plenum Press, New York (1962).

    Google Scholar 

  32. H. C. B. Denber, Riv. Neurobiol. 10, 1137–1168 (1964).

    Google Scholar 

  33. D. N. Teller, R. J. C. Levine, H. C. B. Denber, Agressologie 9, 167–189 (1968).

    PubMed  CAS  Google Scholar 

  34. V. de P. Lynch, E. Clemente, S. Carson, J. Pharni. Sci. 56, 477–483 (1967).

    Article  CAS  Google Scholar 

  35. V. Torjescu, Ann. Pharm. Fr. 26, 311–322 (1968).

    PubMed  CAS  Google Scholar 

  36. V. Torjescu, T. Severin, Farmacia (Bucharest) 15, 741–749 (1967).

    CAS  Google Scholar 

  37. G. Aghajanian, Biochem. Pharmacol. 12, 7–12 (1963).

    Article  PubMed  CAS  Google Scholar 

  38. T. Matsubara, B. Hagihara, J. Biochem. 63, 156–154 (1968).

    PubMed  CAS  Google Scholar 

  39. S. Okada, Nara Igaku Zasshi 19, 139–146 (1968).

    CAS  Google Scholar 

  40. J. D. Robinson, J. Lowinger, B. Bettinger, Biochem. Pharmacol. 17, 1113–1116 (1968).

    Article  PubMed  CAS  Google Scholar 

  41. H. Balzer, M. Makinose, W. Hasselbach, Naunyn-Schmeidebergs Arch. Pharmakol. Exp. Pathol. 260(5), 444 455 (1968).

    Article  CAS  Google Scholar 

  42. K. F. Gey, A. Pletscher, Experientia 24, 335–336 (1968).

    Article  PubMed  CAS  Google Scholar 

  43. D. N. Teller, R. Levine, N. Wackman, H. C. B. Denber, Proc. 7th. Int. Cong. Biochem., Abstracts, Vol. 5, No. 2, p. 1031 (1967).

    Google Scholar 

  44. R. J. C. Levine, D. N. Teller, H. C. B. Denber, Mol. Pharmacol. 4, 435–444 (1968).

    PubMed  CAS  Google Scholar 

  45. K. Kaniike, S. Okada, Y. Kurogochi, Nara Igak-u Zasshi 19, 155–158 (1968).

    CAS  Google Scholar 

  46. D. C. B. Mills, G. C. K. Roberts, Nature 213, 35–38 (1967).

    Article  CAS  Google Scholar 

  47. E. De Robertis, J. Gonzalez-Rodriguez, D. N. Teller, FERS Letters 4, 4–8 (1969).

    Article  Google Scholar 

  48. G. Weissmann, in: “The Interaction of Drugs and Subcellular Components in Animal Cells” ( P. N. Campbell, ed.), pp. 203–212, Little, Brown and Company, Boston, Massachusetts (1968).

    Google Scholar 

  49. P. M. Seeman, in: “The Interaction of Drugs and Subcellular Components in Animal Cells” ( P. N. Campbell, ed.), pp. 212–217, Little, Brown and Company, Boston, Massachusetts (1968).

    Google Scholar 

  50. T. Tsunoda, Folia Psychiat. Neurol. Japon. 14, 156–166 (1960).

    CAS  Google Scholar 

  51. Y. H. Oh, W. E. Leitch, S. Axelrod, S. M. Small, R. J. Winzler, B. E. Sanders, Biochem. Pharmacol. 16, 849–861 (1967).

    Article  PubMed  CAS  Google Scholar 

  52. D. N. Teller, H. C. B. Denber, Dis. Nerv. Syst. 29, 93–112 (1968).

    PubMed  CAS  Google Scholar 

  53. K. D. Charalampous, K. E. Walker, J. Kinross-Wright, Psychopharmacologia 9, 48–63 (1966).

    Google Scholar 

  54. G. Badiu, N. Mison-Crighel, J. Neurochem. 13, 1217–1222 (1966).

    Article  PubMed  CAS  Google Scholar 

  55. S. I. Singh, C. L. Malhotra, J. Neurochem. 14, 135–140 (1967).

    Article  PubMed  CAS  Google Scholar 

  56. H. H. Tallan, in: “Amino Acid Pools” ( J. T. Holden, ed.), pp. 465–470, Elsevier Publishing Co., Amsterdam (1962).

    Google Scholar 

  57. H. S. Bachelard, M. K. Gaitonde, R. Vrba, Biochem. Pharmacol. 15, 1039–1043 (1966).

    Article  PubMed  CAS  Google Scholar 

  58. S. Larsson, Acta Physiol. Scand. 53, 68–74 (1961).

    Article  PubMed  CAS  Google Scholar 

  59. K. F. Gey, M. Rutishauser, A. Pletscher, Biochem. Pharmacol. 14, 507–514 (1965).

    Article  PubMed  CAS  Google Scholar 

  60. A. Lajtha, J. Toth, Biochem. Pharmacol. 14, 729–738 (1965).

    Article  PubMed  CAS  Google Scholar 

  61. D. N. Teller, H. C. B. Denber, in: “Neuropsychopharmacology” (P. B. Bradley, F. Flugel, P. Hoch, eds.), Vol. 3, pp. 423–426, Elsevier Publishing Co., Amsterdam (1964).

    Google Scholar 

  62. H. C. B. Denber, D. N. Teller, P. Rajotte, D. Kauffman, Ann. N.Y. Acad. Sci. 96, 14–36 (1962).

    Article  PubMed  CAS  Google Scholar 

  63. R. Molenda, A. Obrzut, Przegl. Lek. Ser. 2 (22) 544–547 (1966).

    Google Scholar 

  64. W. D. Ulrich, M. Maess, J. Wirth, Arch. Int. Pharmacodyn. Ther. 167, 80–89 (1967).

    PubMed  CAS  Google Scholar 

  65. W. D. Ulrich, M. Maess, J. Wirth, Arch. Int. Pharmacodyn. Ther. 167, 90–100 (1967).

    PubMed  CAS  Google Scholar 

  66. H. Balzer, M. Makinose, W. Fiehn, W. Hasselbach, Naunyn-Schmiedebergs Arch. Pharmakol. Exp. Pathol., 260 (5), 456–473 (1968).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Research Division Biochemistry Laboratory, Manhattan State Hospital, Ward’s Island, New York, N. Y., USA

    David N. Teller & Herman C. B. Denber

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  1. David N. Teller
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  2. Herman C. B. Denber
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  1. New York State Research Institute for Neurochemistry and Drug Addiction, Ward’ Island, New York City, New York, USA

    Abel Lajtha

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© 1970 Plenum Press, New York

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Teller, D.N., Denber, H.C.B. (1970). Mescaline and Phenothiazines: Recent Studies on Sub-cellular Localization and Effects upon Membranes. In: Lajtha, A. (eds) Protein Metabolism of the Nervous System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8109-9_37

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  • DOI: https://doi.org/10.1007/978-1-4684-8109-9_37

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8111-2

  • Online ISBN: 978-1-4684-8109-9

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