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2, 8-Dihydroxyadeninuria: Or When is a Uric Acid Stone not a Uric Acid Stone?

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Urolithiasis

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Abstract

Purine nucleotides important for normal cellular metabolism are derived endogenously from de novo synthesis and also from recycling of pre-formed purines via the so-called salvage pathway (Figure 1). The latter pathway contains a number of enzymes, the absence of which can lead to disturbances of purine metabolism and also severe clinical symptoms1. An example is the deficiency of the salvage enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRT) which can lead either to the Lesch-Nyhan syndrome or X-linked gout1.

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References

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Author information

Authors and Affiliations

  1. Purine Laboratory, Guy’s Hospital Medical School, SE1 9RT, London Bridge, UK

    H. A. Simmonds, C. F. Potter, A. Sahota & J. S. Cameron

  2. Department of Pediatrics, University of Antwerp, Wilrijk, Belgium

    K. J. Van Acker

  3. The Hospital for Sick Children, Great Ormond Street, WCIN 3JH, London, UK

    M. J. Dillon & T. M. Barratt

Authors
  1. H. A. Simmonds
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  2. K. J. Van Acker
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  3. M. J. Dillon
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  4. T. M. Barratt
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  5. C. F. Potter
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  6. A. Sahota
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  7. J. S. Cameron
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Editor information

Editors and Affiliations

  1. Mayo Clinic, Rochester, Minnesota, USA

    Lynwood H. Smith

  2. The General Infirmary, Leeds, England

    William G. Robertson

  3. University of Florida, Gainesville, Florida, USA

    Birdwell Finlayson

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© 1981 Springer Science+Business Media New York

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Simmonds, H.A. et al. (1981). 2, 8-Dihydroxyadeninuria: Or When is a Uric Acid Stone not a Uric Acid Stone?. In: Smith, L.H., Robertson, W.G., Finlayson, B. (eds) Urolithiasis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8977-4_22

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  • DOI: https://doi.org/10.1007/978-1-4684-8977-4_22

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8979-8

  • Online ISBN: 978-1-4684-8977-4

  • eBook Packages: Springer Book Archive

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