Summary
Soluble protein antigen (Horseradish peroxidase — HRP) administered to rats intratracheally is predominantly phagocytosed by alveolar macrophages and Type-II pneumonocytes. A proportion, after localization on the lumenal surface of the bronchiolar epithelium is transported across the epithelium via the apical cytoplasm and the intercellular space to the region of the basement membrane. The rate of transfer is faster in the epithelium closer to areas of BALT than elsewhere and in these areas there is further significant penetration below the basement membrane into the BALT tissue to facilitate the contact of antigen and of lymphoid cells. No evidence of alveolar macrophage re-entry to the lymphatic system after phagocytosis of HRP could be seen.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
K.G. Bensch, E. Dominguez, and A.A. Liebow. Science 157:1204 (1967).
J. Bienenstock, N. Johnston, and D.Y.E. Perey. Lab. Invest. 28(6):686 (1973).
J. Fawell, and D.J. Lewis. Lab. Animais 5:267 (1971).
R.C. Graham, and M.J. Karnovsky. J. Histochem. Cytochem. 14: 291 (1966).
R.L. Gregson, M.J. Davey, and D.E. Prentice. Lab. Animais 13:237 (1979a).
R.L. Gregson, M.J. Davey, and D.E. Prentice. Br. J. Exp. Path. 60:471 (1979b).
K. Ono. Anat. Embryol. 151:53 (1977).
R.L. Owen. Gastroenterology 72:440 (1977).
A.S. Simani, S. Inoue, and J.C. Hogg. Lab. Invest. 31(1): 75 (1974).
J. Richardson, T. Bouchard, and C.C. Ferguson. Lab. Invest. 35(4):307 (1976).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1982 Plenum Press, New York
About this chapter
Cite this chapter
Gregson, R.L., Edmondson, N.A., Plesch, B. (1982). Preferential Uptake of Soluble Antigen by Respiratory Tract Epithelium Overlying Bronchus-Associated Lymphoid Tissue in the Rat. In: Nieuwenhuis, P., van den Broek, A.A., Hanna, M.G. (eds) In Vivo Immunology. Advances in Experimental Medicine and Biology, vol 149. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-9066-4_70
Download citation
DOI: https://doi.org/10.1007/978-1-4684-9066-4_70
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-9068-8
Online ISBN: 978-1-4684-9066-4
eBook Packages: Springer Book Archive