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Hormonal Control of Gluconeogenesis

  • Chapter
Hormones and Energy Metabolism

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 111))

Abstract

Gluconeogenesis is the process by which glucose and glycogen are synthesized in the animal body from noncarbohydrate precursors. The liver and the kidney are the two organs which carry out gluconeogenesis and gluconeogenic substrates include lactate, pyruvate, glycerol, and the glucogenic amino acids. Although all the natural amino acids except leucine and lysine are potentially glucogenic by virtue of the fact that they yield pyruvate, oxalacetate, aketoglutarate, succinyl-CoA, or fumarate during their catabolism, studies in the perfused liver indicate that only alanine, serine, proline, threonine, glutamine, asparagine, glutamate, aspartate, and arginine yield significant amounts of carbohydrate (Ross, Hems, and Krebs, 1967).

Investigator and Director, Howard Hughes Medical Institute Laboratories for the Studies of Metabolic Disorders. Unpublished studies supported by grants 5 P01 AM 07462, 1 R01 AM 18660, and 1 P17 AM 17026 from the National Institutes of Health, U.S. Public Health Service.

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  1. Department of Physiology, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA

    J. H. Exton

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  1. University of Missouri-Columbia, USA

    David M. Klachko M.D. (Associate Professor of Medicine), Ralph R. Anderson Ph.D. (Associate Professor of Dairy Husbandry) & Murray Heimberg M.D., Ph.D. (Professor and Chairman of Pharmacology, Professor of Medicine) (Associate Professor of Medicine),  (Associate Professor of Dairy Husbandry) &  (Professor and Chairman of Pharmacology, Professor of Medicine)

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Exton, J.H. (1979). Hormonal Control of Gluconeogenesis. In: Klachko, D.M., Anderson, R.R., Heimberg, M. (eds) Hormones and Energy Metabolism. Advances in Experimental Medicine and Biology, vol 111. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0734-2_7

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