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Functional Aspects of Angiotensin Type 2 Receptor

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Recent Advances in Cellular and Molecular Aspects of Angiotensin Receptors

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 396))

Abstract

Angiotensin II (AngII) exerts various actions in its diverse target tissues controlling vascular tone, hormone secretion, tissue growth, and neuronal activities. Extensive pharmacological evidence indicates that most of the known effects of AngII in adult tissues are mediated by the seven-transmembrane G-protein coupled Angll type 1 (AT1) receptor. Recently, a second receptor subtype known as type 2 (AT2) receptor has been described and cloned by us and others (1,2). However, little is known about the regulation and physiological function(s) of this novel receptor. The intracellular signal transduction mechanism after the activation of AT2 receptor is not also well defined. The AT2 receptor is abundantly and widely expressed in fetal tissues and immature brain, but present only in at low levels in adult tissues such as adrenal gland, specific brain regions, uterine myometrium, and atretic ovarian follicles (3–5). The highly abundant expression of this receptor during embryonic and neonatal growth and quick disappearance after birth has led us to the suggestion that this receptor may be involved in growth, development and/or differentiation.

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Authors and Affiliations

  1. Cardiovascular Medicine, Falk Cardiovascular Research Center, Stanford University School of Medicine, Stanford, California, USA

    Masatsugu Horiuchi

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  1. Masatsugu Horiuchi
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Editors and Affiliations

  1. University of Florida, Gainesville, Florida, USA

    Mohan K. Raizada , M. Ian Phillips  & Colin Sumners ,  & 

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© 1996 Springer Science+Business Media New York

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Horiuchi, M. (1996). Functional Aspects of Angiotensin Type 2 Receptor. In: Raizada, M.K., Phillips, M.I., Sumners, C. (eds) Recent Advances in Cellular and Molecular Aspects of Angiotensin Receptors. Advances in Experimental Medicine and Biology, vol 396. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1376-0_23

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  • DOI: https://doi.org/10.1007/978-1-4899-1376-0_23

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1378-4

  • Online ISBN: 978-1-4899-1376-0

  • eBook Packages: Springer Book Archive

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