The Coronaviridae

1. Front Matter

   Pages i-xviii

   PDF

2. The Coronaviridae

   • Stuart G. Siddell

   Pages 1-10

3. Coronavirus Replication, Transcription, and RNA Recombination

   • Robbert G. van der Most, Willy J. M. Spaan

   Pages 11-31

4. Coronavirus Gene Expression

   • Willem Luytjes

   Pages 33-54

5. Coronavirus Receptors

   • Kathryn V. Holmes, Susan R. Compton

   Pages 55-71

6. The Coronavirus Surface Glycoprotein

   • David Cavanagh

   Pages 73-113

7. The Coronavirus Membrane Glycoprotein

   • Peter J. M. Rottier

   Pages 115-139

8. The Coronavirus Nucleocapsid Protein

   • Hubert Laude, Paul S. Masters

   Pages 141-163

9. The Coronavirus Hemagglutinin Esterase Glycoprotein

   • David A. Brian, Brenda G. Hogue, Thomas E. Kienzle

   Pages 165-179

10. The Small-Membrane Protein

    • Stuart G. Siddell

    Pages 181-189

11. The Coronavirus Nonstructural Proteins

    • T. D. K. Brown, I. Brierley

    Pages 191-217

12. The Molecular Biology of Toroviruses

    • Eric J. Snijder, Marian C. Horzinek

    Pages 219-238

13. The Coronaviruslike Superfamily

    • Eric J. Snijder, Willy J. M. Spaan

    Pages 239-255

14. Pathogenesis and Diseases of the Central Nervous System Caused by Murine Coronaviruses

    • Samuel Dales, Robert Anderson

    Pages 257-292

15. Feline Infectious Peritonitis

    • Raoul J. de Groot, Marian C. Horzinek

    Pages 293-315

16. Epidemiology of Infectious Bronchitis Virus

    • Jane K. A. Cook, A. P. A. Mockett

    Pages 317-335

17. Molecular Basis of Transmissible Gastroenteritis Virus Epidemiology

    • Luis Enjuanes, Bernard A. M. van der Zeijst

    Pages 337-376

18. Pathogenesis of the Porcine Coronaviruses

    • David J. Garwes

    Pages 377-388

19. Human Coronavirus Infections

    • Steven H. Myint

    Pages 389-401

20. The Pathogenesis of Torovirus Infections in Animals and Humans

    • Marion Koopmans, Marian C. Horzinek

    Pages 403-413

Coronaviruses were recognized as a group of enveloped, RNA viruses in 1968 and accepted by the International Committee on the Taxonomy of Viruses as a separate family, the Coronaviridae, in 1975. By 1978, it had become evident that the coronavirus genomic RNA was infectious (i. e. , positive strand), and by 1983, at least the framework of the coronavirus replication strategy had been per­ ceived. Subsequently, with the application of recombinant DNA techniques, there have been remarkable advances in our understanding of the molecular biology of coronaviruses, and a mass of structural data concerning coronavirus genomes, mRNAs, and pro teins now exists. More recently, attention has been focused on the role of essential and accessory gene products in the coronavirus replication cyde and a molecular analysis of the structure-function relation­ ships of coronavirus proteins. Nevertheless, there are still large gaps in our knowledge, for instance, in areas such as the genesis of coronavirus subgenomic mRNAs or the function of the coronavirus RNA-dependent RNA polymerase. The diseases caused by coronaviruses have been known for much longer than the agents themselves. Possibly the first coronavirus-related disease to be recorded was feline infectious peritonitis, as early as 1912. The diseases associ­ ated with infectious bronchitis virus, transmissible gastroenteritis virus, and murine hepatitis virus were all well known before 1950.

• Pathogene
• RNA
• nervous system
• protein
• transcription
• virus

• Institute of Virology, University of Würzburg, Würzburg, Germany

  Stuart G. Siddell

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