Abstract
An earlier review of antitumor and cytotoxic compounds from marine organisms which covered the literature into early 1986 was published in 1987 by Munro et al. (1987). The current review is intended to provide a comprehensive review of the field from the beginning of 1986 to early 1991. The primary aim was to include all the marine natural products reported to have any type of cytotoxic or antitumor activity. In addition to compounds reported to be toxic to a variety of cultured cancer cell lines, we have included compounds that show activity in the brine shrimp assay or which inhibit development of fertilized sea urchin or starfish eggs, simple assays which correlate to some extent with cytotoxicity. A considerable literature has developed regarding some of the most promising marine antitumor agents, such as didemnin B, the bryostatins, and the dolastatins. Information on some of the pharmacologic and mechanistic studies of these compounds has been included. The chapter is organized according to structural type, although in some cases a given compound could be assigned equally well to different categories.
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Review Articles on Cytotoxiciantitumor Compounds from Marine Organisms
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Schmitz, F.J., Bowden, B.F., Toth, S.I. (1993). Antitumor and Cytotoxic Compounds from Marine Organisms. In: Attaway, D.H., Zaborsky, O.R. (eds) Pharmaceutical and Bioactive Natural Products. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2391-2_7
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