Abstract
Conjugated dienoic derivatives of linoleic acid (referred to by the acronym CLA) constitute a newly recognized class of anticarcinogenic fatty acids. Of the eight major CIA isomere, the cis-9, trans-11 isomer alone is incorporated into phospholipid and may to be the most biologically relevant isomer. CLA exhibits potent antioxidant activity; evidence is presented indicating that CLA acts both as an in vitro and in vivo antioxidant. The formation of CLA in foods, and its possible biological significance in cell membranes, is discussed.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Benjamin, H., Storkson, J. M., Albright, K., and Pariza, M. W. (1990). TPA-mediated induction of ornithine decarboxylase activity in mouse forestomach and its inhibition by conjugated dienoic derivatives of linoleic acid. FASEB J., 4, A508 (abstract # 1403).
Dormandy, T.L. and Wickens, D. G. (1987). The experimental and clinical pathology of diene conjugation. Chem. Phys. Lipids 45, 353–364.
Ha, Y. L., Grimm, N. K., and Pariza, M. W. (1987). Anticarcinogens from fried ground beef: heat altered derivatives of linoleic acid. Carcinogenesis 8, 1881–1887.
Ha, Y. L., Grimm, N. K., and Pariza, M. W. (1989). Newly recognized anticarcinogenic fatty acids: identification and quantification in natural and processed cheeses. J. Agric. Fd. Chem., 37, 75–81.
Ha, Y. L., Storkson, J., and Pariza, M. W. (1990). Inhibition of benzo[a]pyrene-induced mouse forestomach neoplasia by conjugated dienoic derivatives of linoleic acid. Cancer Research 50, 1097–1101.
Kepler, C. R. and Tove, S. B. (1967). Biohydrogenation of unsaturated fatty acids. J. Biol. Chem, 242, 5686–5692.
Osawa, T. and Namiki, M. (1985). Natural antioxidants isolated from Eucalyptus leaf waxes. J. Agric. Food Chem. 33, 777–780.
Merrill, A.H. (1989). Lipid modulators of cell function. Nutrition Rev. 47, 161–169.
Pariza, M. W. (1988). Dietary fat and cancer: evidence and research needs. Ann. Rev. Nutrit. 8, 167–183.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer Science+Business Media New York
About this chapter
Cite this chapter
Pariza, M.W. et al. (1991). Formation and Action of Anticarcinogenic Fatty Acids. In: Friedman, M. (eds) Nutritional and Toxicological Consequences of Food Processing. Advances in Experimental Medicine and Biology, vol 289. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2626-5_19
Download citation
DOI: https://doi.org/10.1007/978-1-4899-2626-5_19
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-2628-9
Online ISBN: 978-1-4899-2626-5
eBook Packages: Springer Book Archive