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Genetic Approaches in Preeclampsia

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Preeclampsia

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1710))

Abstract

Preeclampsia (PE) is a serious hypertensive disorder that affects up to 8% of all pregnancies annually. An established risk factor for PE is family history, clearly demonstrating an underlying genetic component to the disorder. To date, numerous genetic studies, using both the candidate gene and genome-wide approach, have been undertaken to tease out the genetic basis of PE and understand its origins. Such studies have identified some promising candidate genes such as STOX1 and ACVR2A. Nevertheless, researchers face ongoing challenges of replicating these genetic associations in different populations and performing the functional validation of identified genetic variants to determine their causality in the disorder. This chapter will review the genetic approaches used in the study of PE, discuss their limitations and possible confounders, and describe current strategies.

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Author information

Authors and Affiliations

  1. Department of Maternal-Fetal Medicine Pregnancy Research Centre, The Royal Women’s Hospital, Melbourne, VIC, Australia

    Hannah E. J. Yong & Shaun P. Brennecke

  2. Department of Obstetrics and Gynaecology, The University of Melbourne, Melbourne, VIC, Australia

    Hannah E. J. Yong & Shaun P. Brennecke

  3. Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, The University of Cambridge, Cambridge, UK

    Hannah E. J. Yong

  4. Department of Medicine, School of Clinical Sciences, Monash University, Clayton, VIC, Australia

    Padma Murthi

  5. Department of Obstetrics and Gynaecology, School of Clinical Sciences, Monash University, Clayton, VIC, Australia

    Padma Murthi

  6. The Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia

    Padma Murthi

  7. Centre for Genetic Origins of Health and Disease, The University of Western Australia, Perth, Australia

    Eric K. Moses

Authors
  1. Hannah E. J. Yong
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  2. Padma Murthi
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  3. Shaun P. Brennecke
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  4. Eric K. Moses
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Corresponding author

Correspondence to Hannah E. J. Yong .

Editor information

Editors and Affiliations

  1. Monash Medical Centre, Monash University, Clayton, Victoria, Australia

    Padma Murthi

  2. INRS-Institut Armand-Frappier, Laval, Québec, Canada

    Cathy Vaillancourt

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Yong, H.E.J., Murthi, P., Brennecke, S.P., Moses, E.K. (2018). Genetic Approaches in Preeclampsia. In: Murthi, P., Vaillancourt, C. (eds) Preeclampsia . Methods in Molecular Biology, vol 1710. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7498-6_5

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  • DOI: https://doi.org/10.1007/978-1-4939-7498-6_5

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