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Inflammation and Cancer pp 77–89Cite as

Citrobacter rodentium Infection Model for the Analysis of Bacterial Pathogenesis and Mucosal Immunology

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1725))

Abstract

Citrobacter rodentium is a mouse restricted pathogen that was originally isolated from laboratory mouse colonies and causes transmissible colonic hyperplasia, characterized by thickening of the colon and inflammation. As a natural pathogen of mice, the infection model has proven critical to the development of our understanding of the pathogenesis of enteric disease and the mucosal immune response. In addition to this, some features of disease such as dysbiosis, inflammation, and wound healing replicate features of human inflammatory bowel diseases. As such, the C. rodentium infection model has become a key tool in investigations of many aspects of mucosal immunology.

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Author information

Authors and Affiliations

  1. Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia

    Catherine L. Kennedy & Elizabeth L. Hartland

  2. Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, 3168, Australia

    Elizabeth L. Hartland

  3. Department of Molecular and Translational Science, Monash University, Clayton, 3168, Australia

    Elizabeth L. Hartland

Authors
  1. Catherine L. Kennedy
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  2. Elizabeth L. Hartland
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Corresponding author

Correspondence to Elizabeth L. Hartland .

Editor information

Editors and Affiliations

  1. Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia

    Brendan J. Jenkins

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Kennedy, C.L., Hartland, E.L. (2018). Citrobacter rodentium Infection Model for the Analysis of Bacterial Pathogenesis and Mucosal Immunology. In: Jenkins, B. (eds) Inflammation and Cancer. Methods in Molecular Biology, vol 1725. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7568-6_7

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  • DOI: https://doi.org/10.1007/978-1-4939-7568-6_7

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7567-9

  • Online ISBN: 978-1-4939-7568-6

  • eBook Packages: Springer Protocols

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