Abstract
Animal models of arthritis enable us to investigate the pathogenesis of the disease and also to evaluate new therapies. Here we describe two different acute inflammatory monoarticular arthritis models (mBSA/IL1β and mBSA/GM-CSF) providing a more rapid and potentially simplified approach to investigate the pathogenesis.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Bischof RJ, Zafiropoulos D, Hamilton JA et al (2000) Exacerbation of acute inflammatory arthritis by the colony-stimulating factors CSF-1 and granulocyte macrophage (GM)-CSF: evidence of macrophage infiltration and local proliferation. Clin Exp Immunol 119:361–367
Staite ND, Richard KA, Aspar DG et al (1990) Induction of an acute erosive monarticular arthritis in mice by interleukin-1 and methylated bovine serum albumin. Arthritis Rheum 33:253–260
Cook AD, Braine EL, Hamilton JA (2004) Stimulus-dependent requirement for granulocyte-macrophage colony-stimulating factor in inflammation. J Immunol 173:4643–4651
Cook AD, Pobjoy J, Sarros S et al (2013) Granulocyte-macrophage colony-stimulating factor is a key mediator in inflammatory and arthritic pain. Ann Rheum Dis 72:265–270
Lawlor KE, Campbell IK, O’Donnell K et al (2001) Molecular and cellular mediators of interleukin-1-dependent acute inflammatory arthritis. Arthritis Rheum 44:442–450
Lawlor KE, van Nieuwenhuijze A, Parker KL et al (2013) Bcl-2 overexpression ameliorates immune complex-mediated arthritis by altering FcgammaRIIb expression and monocyte homeostasis. J Leukoc Biol 93:585–597
Lawlor KE, Wong PK, Campbell IK et al (2005) Acute CD4+ T lymphocyte-dependent interleukin-1-driven arthritis selectively requires interleukin-2 and interleukin-4, joint macrophages, granulocyte-macrophage colony-stimulating factor, interleukin-6, and leukemia inhibitory factor. Arthritis Rheum 52:3749–3754
Wong PK, Campbell IK, Robb L et al (2005) Endogenous IL-11 is pro-inflammatory in acute methylated bovine serum albumin/interleukin-1-induced (mBSA/IL-1)arthritis. Cytokine 29:72–76
Yang YH, Hamilton JA (2001) Dependence of interleukin-1-induced arthritis on granulocyte-macrophage colony-stimulating factor. Arthritis Rheum 44:111–119
Kay J, Calabrese L (2004) The role of interleukin-1 in the pathogenesis of rheumatoid arthritis. Rheumatology (Oxford) 43(Suppl 3):iii2–iii9. https://doi.org/10.1093/rheumatology/keh201
Hamilton JA, Achuthan A (2013) Colony stimulating factors and myeloid cell biology in health and disease. Trends Immunol 34:81–89
Dinarello CA (2011) Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood 117:3720–3732
Hamilton JA, Cook AD, Tak PP (2016) Anti-colony-stimulating factor therapies for inflammatory and autoimmune diseases. Nat Rev Drug Discov 16:53–70
Achuthan A, Cook AD, Lee MC et al (2016) Granulocyte macrophage colony-stimulating factor induces CCL17 production via IRF4 to mediate inflammation. J Clin Invest 126:3453–3466
Brand DD, Latham KA, Rosloniec EF (2007) Collagen-induced arthritis. Nat Protoc 2:1269–1275
Acknowledgments
This work was supported by a grant from the National Health and Medical Research Council (NHMRC).
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer Science+Business Media, LLC, part of Springer Nature
About this protocol
Cite this protocol
Achuthan, A., Lee, MC., Saleh, R., Fleetwood, A.J., Hamilton, J.A., Cook, A.D. (2018). Cytokine-Induced Acute Inflammatory Monoarticular Arthritis. In: Rousselet, G. (eds) Macrophages. Methods in Molecular Biology, vol 1784. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7837-3_20
Download citation
DOI: https://doi.org/10.1007/978-1-4939-7837-3_20
Published:
Publisher Name: Humana Press, New York, NY
Print ISBN: 978-1-4939-7836-6
Online ISBN: 978-1-4939-7837-3
eBook Packages: Springer Protocols