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Cytokine-Induced Acute Inflammatory Monoarticular Arthritis

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Macrophages

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1784))

Abstract

Animal models of arthritis enable us to investigate the pathogenesis of the disease and also to evaluate new therapies. Here we describe two different acute inflammatory monoarticular arthritis models (mBSA/IL1β and mBSA/GM-CSF) providing a more rapid and potentially simplified approach to investigate the pathogenesis.

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References

  1. Bischof RJ, Zafiropoulos D, Hamilton JA et al (2000) Exacerbation of acute inflammatory arthritis by the colony-stimulating factors CSF-1 and granulocyte macrophage (GM)-CSF: evidence of macrophage infiltration and local proliferation. Clin Exp Immunol 119:361–367

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Staite ND, Richard KA, Aspar DG et al (1990) Induction of an acute erosive monarticular arthritis in mice by interleukin-1 and methylated bovine serum albumin. Arthritis Rheum 33:253–260

    Article  CAS  PubMed  Google Scholar 

  3. Cook AD, Braine EL, Hamilton JA (2004) Stimulus-dependent requirement for granulocyte-macrophage colony-stimulating factor in inflammation. J Immunol 173:4643–4651

    Article  CAS  PubMed  Google Scholar 

  4. Cook AD, Pobjoy J, Sarros S et al (2013) Granulocyte-macrophage colony-stimulating factor is a key mediator in inflammatory and arthritic pain. Ann Rheum Dis 72:265–270

    Article  CAS  PubMed  Google Scholar 

  5. Lawlor KE, Campbell IK, O’Donnell K et al (2001) Molecular and cellular mediators of interleukin-1-dependent acute inflammatory arthritis. Arthritis Rheum 44:442–450

    Article  CAS  PubMed  Google Scholar 

  6. Lawlor KE, van Nieuwenhuijze A, Parker KL et al (2013) Bcl-2 overexpression ameliorates immune complex-mediated arthritis by altering FcgammaRIIb expression and monocyte homeostasis. J Leukoc Biol 93:585–597

    Article  CAS  PubMed  Google Scholar 

  7. Lawlor KE, Wong PK, Campbell IK et al (2005) Acute CD4+ T lymphocyte-dependent interleukin-1-driven arthritis selectively requires interleukin-2 and interleukin-4, joint macrophages, granulocyte-macrophage colony-stimulating factor, interleukin-6, and leukemia inhibitory factor. Arthritis Rheum 52:3749–3754

    Article  CAS  PubMed  Google Scholar 

  8. Wong PK, Campbell IK, Robb L et al (2005) Endogenous IL-11 is pro-inflammatory in acute methylated bovine serum albumin/interleukin-1-induced (mBSA/IL-1)arthritis. Cytokine 29:72–76

    Article  CAS  PubMed  Google Scholar 

  9. Yang YH, Hamilton JA (2001) Dependence of interleukin-1-induced arthritis on granulocyte-macrophage colony-stimulating factor. Arthritis Rheum 44:111–119

    Article  PubMed  Google Scholar 

  10. Kay J, Calabrese L (2004) The role of interleukin-1 in the pathogenesis of rheumatoid arthritis. Rheumatology (Oxford) 43(Suppl 3):iii2–iii9. https://doi.org/10.1093/rheumatology/keh201

    Article  Google Scholar 

  11. Hamilton JA, Achuthan A (2013) Colony stimulating factors and myeloid cell biology in health and disease. Trends Immunol 34:81–89

    Article  CAS  PubMed  Google Scholar 

  12. Dinarello CA (2011) Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood 117:3720–3732

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Hamilton JA, Cook AD, Tak PP (2016) Anti-colony-stimulating factor therapies for inflammatory and autoimmune diseases. Nat Rev Drug Discov 16:53–70

    Article  CAS  PubMed  Google Scholar 

  14. Achuthan A, Cook AD, Lee MC et al (2016) Granulocyte macrophage colony-stimulating factor induces CCL17 production via IRF4 to mediate inflammation. J Clin Invest 126:3453–3466

    Article  PubMed  PubMed Central  Google Scholar 

  15. Brand DD, Latham KA, Rosloniec EF (2007) Collagen-induced arthritis. Nat Protoc 2:1269–1275

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

This work was supported by a grant from the National Health and Medical Research Council (NHMRC).

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Correspondence to Adrian Achuthan .

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Achuthan, A., Lee, MC., Saleh, R., Fleetwood, A.J., Hamilton, J.A., Cook, A.D. (2018). Cytokine-Induced Acute Inflammatory Monoarticular Arthritis. In: Rousselet, G. (eds) Macrophages. Methods in Molecular Biology, vol 1784. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7837-3_20

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  • DOI: https://doi.org/10.1007/978-1-4939-7837-3_20

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7836-6

  • Online ISBN: 978-1-4939-7837-3

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