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High-Grade Gliomas pp 461–484Cite as

Photodynamic Therapy

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Part of the book series: Current Clinical Oncology ((CCO))

Abstract

Cerebral gliomas are inherently invasive tumors, and the vast majority of tumors recur locally despite optimal conventional therapies. Photodynamic therapy has been used as an adjuvant therapy to help control the tumor locally. Photodynamic therapy is a binary treatment involving the selective uptake of a sensitizer by the cancer cell followed by irradiation of the tumor to activate the retained photosensitizer, thereby causing selective tumor destruction. Laboratory investigations have confirmed the selective uptake of sensitizers as well as determining the optimal therapeutic index dose of sensitizer and irradiated light. Clinical studies have shown that when photodynamic therapy is used as an adjuvant it may have significant benefit in not only controlling local disease but also prolonging tumor-free survival.

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  1. Departments of Neurosurgery and Surgery, University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria, Australia

    Bhadrakant Kavar & Andrew H. Kaye

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  1. Bhadrakant Kavar
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  1. Department of Neurological Surgery Cleveland Clinic Foundation, Brain Tumor Institute, Cleveland, OH

    Gene H. Barnett MD

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Kavar, B., Kaye, A.H. (2007). Photodynamic Therapy. In: Barnett, G.H. (eds) High-Grade Gliomas. Current Clinical Oncology. Humana Press. https://doi.org/10.1007/978-1-59745-185-7_27

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  • DOI: https://doi.org/10.1007/978-1-59745-185-7_27

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