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Understanding the Nature of Prion Diseases Using Cell-free Assays

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Book cover Prion Protein Protocols

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 459))

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Summary

A central event in the transmission and pathogenesis of transmissible spongiform encephalopathy diseases is the misfolding of the prion protein. Considerable progress has been made in our understanding of this misfolding event through the development of cell-free assays that mimic the molecular features of prion propagation. This chapter reviews the contribution of cell-free assays to our understanding of prion propagation.

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Acknowledgments

This work was supported by the National Health and Medical Research Council (NHMRC) of Australia fellowship 209163 and project grants 400229 and 454546.

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Authors and Affiliations

  1. Department of Pathology and Mental Health Research Institute of Victoria, University of Melbourne, Melbourne, Australia

    Victoria A. Lawson

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  1. Victoria A. Lawson
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Editors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute; Department of Pathology and Mental Health Institute of Victoria, University of Melbourne, 30 Flemington Road Parkville, Melbourne, VIC, 3010, Australia

    Andrew F. Hill

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© 2008 Humana Press, a part of Springer Science + Business Media, LLC

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Lawson, V.A. (2008). Understanding the Nature of Prion Diseases Using Cell-free Assays. In: Hill, A.F. (eds) Prion Protein Protocols. Methods in Molecular Biology™, vol 459. Humana Press. https://doi.org/10.1007/978-1-59745-234-2_7

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  • DOI: https://doi.org/10.1007/978-1-59745-234-2_7

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-897-3

  • Online ISBN: 978-1-59745-234-2

  • eBook Packages: Springer Protocols

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