Key Points
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Economic evaluation of the Mediterranean diet for patients following first AMI (acute myocardial infarction).
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A cost utility analysis was conducted, using a Markov model to describe health status, costs, quality of life and deaths to compare the Mediterranean diet to a prudent Western diet.
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Program effectiveness was based on the Lyon Diet Heart Study.
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Costs were estimated in $AU, (and converted to $US and €Euros) based on reported resource use.
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Performance was measured as cost per quality adjusted life year (QALY) gained.
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Extensive one-way sensitivity analyses were performed.
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The Mediterranean diet was estimated to cost less and be more effective (dominant) compared with a prudent Western diet.
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There was a mean gain in life years of 0.56 per person and a gain in quality adjusted life years of 0.61 per person.
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Based on the published results from the Lyon Diet Heart Study, and conservative assumptions, the Mediterranean diet is cost saving for persons following first AMI when modeled over 10 years.
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Policy makers and clinicians should strongly consider application of results to their own setting.
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References
Health Organisation (WHO). Cardiovascular Diseases (CVD). Fact Sheet No. 317, Updated September 2009 [online] http://www.who.int/mediacentre/factsheets/fs317/ Accessed 11 Dec 2009.
National Centre for Chronic Disease Prevention and Health Promotion (CDC). Heart Disease and Stroke Prevention: Addressing the Nation’s Leading Killers, At a Glance 2009 [online] http://www.cdc.gov/NCCDPHP/publications/AAG/dhdsp.htm Accessed 11 Dec 2009.
de Lorgeril M, Salen P, Martin J-L, et al. Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study. Circulation. 1999;99:779–85.
Elley CR, Kerse N, Arroll B, et al. Effectiveness of counselling patients on physical activity in general practice: cluster randomized controlled trial. Br Med J. 2003;326:793–8.
Steptoe A, Perkins-Porras L, McKay C, et al. Behavioural counselling to increase consumption of fruit and vegetables in low income adults: randomized trial. Br Med J. 2003;326:855.
Eriksson J, Lindström J, Valle T, on behalf of the Finnish Diabetes Prevention Study Group, et al. Prevention of type II diabetes in subjects with impaired glucose tolerance: the Diabetes Prevention Study (DPS) in Finland. Diabetologica. 1999;42:793–801.
de Lorgeril M, Renaud S, Mamelle N, et al. Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease. Lancet. 1994;343:1454–9.
Sondergaard E, Moller JE, Egstrup K. Effect of dietary intervention and lipid-lowering treatment on brachial vasoreactivity in patients with ischemic heart disease and hypercholesterolemia. Am Heart J. 2003;145:903.
Singh RB, Dubnov G, Niaz MA, et al. Effect of an Indo-Mediterranean diet on progression of coronary artery disease in high risk patients (Indo-Mediterranean Diet Heart Study): a randomized single-blind trial. Lancet. 2002;360:1455–61.
Tuttle KR, Shuler LA, Packard DP, et al. Comparison of low-fat versus Mediterranean-style dietary intervention after first myocardial infarction (from The Heart Institute of Spokane Diet Intervention and Evaluation Trial). Am J Cardiol. 2008;101(11):1523–30.
de Lorgeril M, Salen P, Martin J-L, et al. Effect of a Mediterranean type of diet on the rate of cardiovascular complications in patients with coronary artery disease. Insights into the cardioprotective effect of certain nutriments. J Am Col Cardiol. 1996;28:1103–8.
de Lorgeril M, Salen P, Caillat-Vallet E, et al. Control of bias in dietary trial to prevent coronary recurrences: The Lyon diet heart study. Eur J Clin Nutr. 1997;51:116–22.
Richardson J. Cost utility analysis: what should be measured? Soc Sci Med. 1994;39:7–21.
Pope R. Biases from omitted risk effects in standard gamble utilities. J Health Econ. 2004;23:695–735.
Kuntz KM, Tsevat J, Goldman L, et al. Cost-effectiveness of routine coronary angiography after acute myocardial infarction. Circulation. 1996;94:957–65.
Lee TT, Solomon NA, Heidenreich PA, et al. Cost-effectiveness of screening for carotid stenosis in asymptomatic persons. Ann Intern Med. 1997;126:337–46.
Derdeyn CP, Powers WJ. Cost effectiveness of screening for asymptomatic carotid atherosclerotic disease. Stroke. 1996;27:1944–50.
Australian Government Department of Health and Ageing. Medicare Benefits Schedule Book. Nov 2009 Commonwealth of Australia, Canberra
Melbourne University Design and Print Centre. 2003. Quote based on eight A4 pages.
Coles Myer. Coles Online. www.colesonline.com.au Accessed December 2009.
Australian Institute of Health and Welfare (AIHW). 2005. Australian Hospital Statistics, 2002–3 for public hospitals.
Cadilhac DA, Carter R, Thrift AG, et al. Estimating the long-term costs of ischemic and hemorrhagic stroke for Australia: new evidence derived from the North East Melbourne Stroke Incidence Study (NEMESIS). Stroke. 2009;40(3):915–21.
Miller DK, Homan SM. Determining transition probabilities: confusion and suggestions. Med Decis Mak. 1994;14:52–8.
Antiplatelet Trialists’ Collaboration. Collaborative overview of randomized trials of antiplatelet therapy. Br Med J. 1994;308:81–106.
Tanne D, Shotan A, Goldbourt U, for the Bezafibrate Infarction Prevention Study Group, et al. Severity of angina pectoris and risk of ischemic stroke. Stroke. 2002;33:245–50.
Peltonen M, Lundberg V, Huhtasaari F, et al. Marked improvement in survival after acute myocardial infarction in middle-aged men but not women. The Northern Sweden MONICA study 1985–94. J Intern Med. 2000;247:579–87.
Heit JA, Silvertein MD, Mohr DN, et al. Predictors of survival after deep vein thrombosis and pulmonary embolism- a population based cohort study. Arch Intern Med. 1990;159:445–53.
Petty GW, Brown RD, Whisnant JP, et al. Survival and recurrence after first cerebral infarction: a population based study in Rochester, Minnesota, 1975 through 1989. Neurology. 1998;50:208–16.
Commonwealth Department of Health and Ageing. Guidelines for preparing submissions to the Pharmaceutical Benefits Advisory Committee (Version 4.3). December 2008. Commonwealth of Australia
Trichopoulou A, Costacou T, Barnia C, et al. Adherence to a Mediterranean diet and survival in a Greek population. N Engl J Med. 2003;348:2599–608.
Knoops KTB, de Groot LCPGM, Kromhout D, et al. Mediterranean diet, lifestyle factors, and 10-year mortality in elderly European men and women: The Hale Project. JAMA. 2004;292:1433–9.
Sofi F, Cesari F, Abbate R, Gensini GF, et al. Adherence to Mediterranean diet and health status: meta-analysis. BMJ. 2008;11:1344.
Buckland G, Gonzalez CA, Agudo A, et al. Adherence to the Mediterranean diet and risk of coronary heart disease in the Spanish EPIC Cohort Study. Am J Epidemiol. 2009;170(12):1518–29.
WHO Collaborating Centre on Surveillance of Cardiovascular Diseases. Global Cardiovascular InfoBase: country comparisons [online] http://www.cvdinfobase.ca/data.htm. Accessed March 2005.
Australian Institute of Health and Welfare (AIHW) National Cardiovascular disease and diabetes database: Deaths from acute myocardial infarction in Australia. 2001 [online]. Available at: http://www.aihw.gov.au/pls/cvd/cvd_death.show_form. Accessed March 2005.
Marrugat SH, Covas MI J. High monetary costs of dietary patterns associated with lower body mass index: a population-based study. Int J Obes. 2006;30(10):1574–9.
Lopez CN, Martinez-Gonzalez MA, Sanchez-Villegas A, et al. Costs of Mediterranean and western dietary patterns in a Spanish cohort and their relationship with prospective weight change. J Epidemiol Community Health. 2009;63(11):920–7.
de Lorgeril M, Salen P, Martin JL, Monjaud I, et al. Mediterranean Dietary Pattern in a Randomized Trial: prolonged survival and possible reduced cancer. Arch Intern Med. 1998;158:1181–7.
Leonhauser IU, Dorandt S, Willmund E, et al. The benefit of the Mediterranean diet- considerations to modify German food patterns. Eur J Nutr. 2004;43 Suppl 1:31–8.
de Lorgeril M, Salen P, Paillard F, et al. Mediterranean diet and the French paradox: two distinct biogeographic concepts for one consolidated scientific theory on the role of nutrition in coronary heart disease. Cardiovasc Res. 2002;54:503–15.
Willet WC, Sacks F, Trichopoulou A, et al. Mediterranean diet pyramid: A cultural model for healthy eating. Am J Clin Nutr. 1995;61(6 Suppl 1):1402S–6.
Dalziel K, Segal L, de Lorgeril M. A Mediterranean diet is cost-effective in patients with previous myocardial infarction. J Nutr. 2006;136(7):1879–85.
Prosser LA, Stinnett AA, Goldman PA, et al. Cost-effectiveness of cholesterol-lowering therapies according to selected patient characteristics. Ann Intern Med. 2000;132:769–79.
Probstfield JL. How cost-effective are new preventive strategies for cardiovascular disease. Am J Cardiol. 2003;91:22G–7.
World Health Organisation. Choosing Interventions that are Cost Effective (WHO-CHOICE) [online] http://www.who.int/choice/costs/CER_levels/en/index.html. Accessed December 2009.
Acknowledgments
The authors would like to acknowledge Rachelle Opie who assisted with the identification of model costs and Dr. Michel de Lorgeril who provided clinical guidance and input for earlier related work.
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Dalziel, K., Segal, L. (2011). Cost-Effectiveness Analysis of the Mediterranean Diet for Persons after a Heart Attack. In: Gerald, J., Watson, R., Preedy, V. (eds) Nutrients, Dietary Supplements, and Nutriceuticals. Nutrition and Health. Humana Press. https://doi.org/10.1007/978-1-60761-308-4_22
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