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Oxidative Stress in Ruminants

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Studies on Veterinary Medicine

Abstract

This chapter examines the role that oxidative stress plays in ruminant medicine. We examine how redox homeostasis in involved in some physiological functions and we discuss the implications of the impairment of oxidative status on ruminant health and production. The study of oxidative stress is a relatively young field of research in ruminant medicine. The understanding of the role of oxidants and antioxidants in physiological and pathological conditions is rapidly increasing. Oxidative stress is an active field of research in ruminant medicine and has been implicated in numerous disease processes including sepsis, mastitis, acidosis, ketosis, enteritis, pneumonia, respiratory, and joint diseases. Compared to human medicine, only a limited number of conditions have been investigated in regard to the effects of oxidative stress in ruminants. Studies in cattle have been sporadic and mainly concerned with mastitis, pneumonia, and retained placenta. More recently, studies have been focused on metabolic diseases that affect dairy cows during the peripartum period. Numerous and rapidly evolving methodologies for evaluating oxidative stress are available to researchers and clinicians, each with their own distinct advantages and disadvantages. Differences in models and methodologies make it difficult to make meaningful comparisons, even for studies that seem quite similar superficially. With this in mind, it is the goal of this chapter to summarise the present knowledge of oxidative stress in ruminant medicine and to examine the basis of and evidence for the role of oxidative stress in ruminant health and production, highlighting the need for continued research on oxidative stress in ruminant medicine. Clarity of understanding of the pathophysiology of oxidative stress in ruminants will allow the design of specific antioxidant therapies. Future research should focus on the establishment of a reference panel of biomarker of oxidative stress to be used in ruminant medicine. The development of an oxidative stress index as an approach in ruminant and veterinary medicine is also discussed.

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References

  1. Agarwal, A., Gupta, S., Sharma, R., 2005. Role of oxidative stress in female reproduction. Reproductive Biology and Endocrinology 3, 28.

    PubMed  Google Scholar 

  2. Aitken, R.J., Clarkson, J.S., Fishel, S., 1989. Generation of reactive oxygen species, lipid peroxidation, and human sperm function. Biology of Reproduction 41, 183–197.

    CAS  PubMed  Google Scholar 

  3. Alberti, A., Bolognini, L., Macciantelli, D., Caratelli, M., 2000. The radical cation of N,N-diethyl-para-phenylendiamine: a possible indicator of oxidative stress in biological samples. Research on Chemical Intermediates 26, 253–267.

    CAS  Google Scholar 

  4. Allison, R.D., Laven, R.A., 2000. Effect of vitamin E supplementation on the health and fertility of dairy cows: a review. Veterinary Record 147, 703–708.

    CAS  PubMed  Google Scholar 

  5. Al-Sa’doni, H., Ferro, A., 2000. S-nitrosothiols: a class of nitric oxide-donor drugs. Clinical Science 98, 507–520.

    PubMed  Google Scholar 

  6. Ames, B.N., Cathcart, R., Schwiers, E., Hochstein, P., 1981. Uric acid provides an antioxidant defence in humans against oxidant- and radical-caused aging and cancer: a hypothesis. Proceedings of the National Academy of Sciences of the United States of America 78, 6858–6862.

    CAS  PubMed Central  PubMed  Google Scholar 

  7. Andrés, S., Jimenez, A., Mañé, M.C., Sánchez, J., Barrera, R., 1997. Relationships between some soil parameters and the blood glutathione peroxidase activity of grazing sheep. Veterinary Record 141, 267–268.

    PubMed  Google Scholar 

  8. Andrés, S., Mañé, M.C., Sánchez, J., Barrera, R., Jimenez, A., 1999. Temporal variations in blood glutathione peroxidase (GSHPx) activity in sheep at pasture in a Mediterranean area. Veterinary Journal 157, 186–188.

    Google Scholar 

  9. Aréchiga, C.F., Ortíz, O., Hansen, P.J., 1994. Effect of prepartum injection of vitamin E and selenium on postpartum reproductive function of dairy cattle. Theriogenology 41, 1251–1258.

    PubMed  Google Scholar 

  10. Aréchiga, C.F., Ealy, A.D., Hansen, P.J., 1995. Evidence that glutathione is involved in ­thermotolerance of preimplantation murine embryos. Biology of Reproduction 52, 1296–1301.

    PubMed  Google Scholar 

  11. Aréchiga, C.F., Vázquez-Flores, S., Ortiz, O., Hernández-Cerón, J., Porras, A., McDowell, L.R., Hansen, P.J., 1998. Effect of injection of [beta]-carotene or vitamin E and selenium on fertility of lactating dairy cows. Theriogenology 50, 65–76.

    PubMed  Google Scholar 

  12. Argüelles, S., García, S., Maldonado, M., Machado, A., Ayala, A., 2004. Do the serum oxidative stress biomarkers provide a reasonable index of the general oxidative stress status? Biochimica et Biophysica Acta – General Subjects 1674, 251–259.

    Google Scholar 

  13. Ashworth, C., Antipatis, C., 2001. Micronutrient programming of development throughout gestation. Reproduction 122, 527–535.

    CAS  PubMed  Google Scholar 

  14. Asri Rezaei, S., Dalir-Naghadeh, B., 2006. Evaluation of antioxidant status and oxidative stress in cattle naturally infected with Theileria annulata. Veterinary Parasitology 142, 179–186.

    CAS  PubMed  Google Scholar 

  15. Atabek, M., Keskin, M., Yazici, C., Kendirci, M., Hatipoglu, N., Koklu, E., Kurtoglu, S., 2006. Protein oxidation in obesity and insulin resistance. European Journal of Pediatrics 165, 753–756.

    CAS  PubMed  Google Scholar 

  16. Atakisi, O., Oral, H., Atakisi, E., Merhan, O., Metin Pancarci, S., Ozcan, A., Marasli, S., Polat, B., Colak, A., Kaya, S., 2010. Subclinical mastitis causes alterations in nitric oxide, total oxidant and antioxidant capacity in cow milk. Research in Veterinary Science 89, 10–13.

    CAS  PubMed  Google Scholar 

  17. Au, Y.J.K., Smith, A., Zhao, A., Madden, K.B., Elfrey, J., Sullivan, C., Levander, O., Urban, J.F., Shea-Donohue, T., 2005. Impact of vitamin E or selenium deficiency on nematode-induced alterations in murine intestinal function. Experimental Parasitology 109, 201–208.

    Google Scholar 

  18. Aurousseau, B., Gruffat, D., Durand, D., 2006. Gestation linked radical oxygen species fluxes and vitamins and trace mineral deficiencies in the ruminant. Reproduction Nutrition and Development 46, 601–620.

    CAS  Google Scholar 

  19. Baldi, A., Savoini, G., Pinotti, L., Monfardini, E., Cheli, F., Orto, V.D., 2000. Effects of vitamin E and different energy sources on vitamin E status, milk quality and reproduction in transition cows. Journal of Veterinary Medicine Series A 47, 599–608.

    CAS  PubMed  Google Scholar 

  20. Ballet, N., Robert, J.C., Williams, P.E.V., 2000. Vitamins in forages. In: D.I. Givens, E. Owens., R.F.E. Axford and H.M. Omed (Eds.), Forage Evaluation in Ruminant Nutrition, CABI, Oxon, UK, pp. 399–431.

    Google Scholar 

  21. Bargo, F., Muller, L.D., Delahoy, J.E., Cassidy, T.W., 2002. Milk response to concentrate supplementation of high producing dairy cows grazing at two pasture allowances. Journal of Dairy Science 85, 1777–1792.

    CAS  PubMed  Google Scholar 

  22. Barry, T.N., Reid, T.C., Millar, K.R., Sadler, W.A., 1981. Nutritional evaluation of kale (Brassica oleracea) diets: 2. Copper deficiency, thyroid function, and selenium status in young cattle and sheep fed kale for prolonged periods. The Journal of Agricultural Science 96, 269–282.

    CAS  Google Scholar 

  23. Beatty, D.T., Barnes, A., Taylor, E., Pethick, D., McCarthy, M., Maloney, S.K., 2006. Physiological responses of Bos taurus and Bos indicus cattle to prolonged, continuous heat and humidity. Journal of Animal Science 84, 972–985.

    CAS  PubMed  Google Scholar 

  24. Beck, P.A., Wistuba, T.J., M.E., D., Gunter, S.A., 2005. Case study: effects of feeding supplemental organic or inorganic selenium to cow-calf pairs on selenium status and immune responses of weaned beef calves. Professional Animal Scientist 21, 114–120.

    Google Scholar 

  25. Beckman, J.S., Beckman, T.W., Chen, J., Marshall, P.A., Freeman, B.A., 1990. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proceedings of the National Academy of Sciences of the United States of America 87, 1620–1624.

    CAS  PubMed Central  PubMed  Google Scholar 

  26. Benzie, I.F.F., Strain, J.J., 1996. The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: the FRAP assay. Analytical Biochemistry 239, 70–76.

    CAS  PubMed  Google Scholar 

  27. Bernabucci, U., Ronchi, B., Lacetera, N., Nardone, A., 2002. Markers of oxidative status in plasma and erythrocytes of transition dairy cows during hot season. Journal of Dairy Science 85, 2173–2179.

    CAS  PubMed  Google Scholar 

  28. Bernabucci, U., Ronchi, B., Lacetera, N., Nardone, A., 2005. Influence of body condition score on relationships between metabolic status and oxidative stress in periparturient dairy cows. Journal of Dairy Science 88, 2017–2026.

    CAS  PubMed  Google Scholar 

  29. Bionaz, M., Trevisi, E., Calamari, L., Librandi, F., Ferrari, A., Bertoni, G., 2007. Plasma paraoxonase, health, inflammatory conditions, and liver function in transition dairy cows. Journal of Dairy Science 90, 1740–1750.

    CAS  PubMed  Google Scholar 

  30. Biri, A., Bozkurt, N., Turp, A., Kavutcu, M., Himmetoglu, Z., Durak, I., 2007. Role of oxidative stress in intrauterine growth restriction. Gynecologic and Obstetric Investigation 64, 187.

    CAS  PubMed  Google Scholar 

  31. Blum, J.W., Dosogne, H., Hoeben, D., Vangroenweghe, F., Hammon, H.M., Bruckmaier, R.M., Burvenich, C., 2000. Tumor necrosis factor-[alpha] and nitrite/nitrate responses during acute mastitis induced by Escherichia coli infection and endotoxin in dairy cows. Domestic Animal Endocrinology 19, 223–235.

    CAS  PubMed  Google Scholar 

  32. Bouchard, L., Blais, S., Desrosiers, C., Zhao, X., Lacasse, P., 1999. Nitric oxide production during endotoxin-induced mastitis in the cow. Journal of Dairy Science 82, 2574–2581.

    CAS  PubMed  Google Scholar 

  33. Bourdon, E., Blache, D., 2001. The importance of proteins in defense against oxidation. Antioxidants & Redox Signaling 3, 293–311.

    CAS  Google Scholar 

  34. Bourdon, E., Loreau, N., Blache, D., 1999. Glucose and free radicals impair the antioxidant properties of serum albumin. FASEB Journal 13, 233–244.

    CAS  PubMed  Google Scholar 

  35. Bouwstra, R.J., Goselink, R.M.A., Dobbelaar, P., Nielen, M., Newbold, J.R., van Werven, T., 2008. The relationship between oxidative damage and vitamin E concentration in blood, milk, and liver tissue from vitamin E supplemented and nonsupplemented periparturient heifers. Journal of Dairy Science 91, 977–987.

    CAS  PubMed  Google Scholar 

  36. Bowers, T.L., 1997. Nutrition and immunity part 2: the role of selected micronutrients and clinical significance. Veterinary Clinical Nutrition 4, 96–101.

    Google Scholar 

  37. Bramley, E., Lean, I.J., Fulkerson, W.J., Stevenson, M.A., Rabiee, A.R., Costa, N.D., 2008. The definition of acidosis in dairy herds predominantly fed on pasture and concentrates. Journal of Dairy Science 91, 308–321.

    CAS  PubMed  Google Scholar 

  38. Briviba, K., Sies, H., 1994. Non-enzymatic antioxidants defence system. In: B. Frei (Ed.), Natural Antioxidants in Human Health and Disease, Academic Press, San Diego, CA, pp. 107–128.

    Google Scholar 

  39. Broom, D.M., 2000. Welfare assessment and welfare problem areas during handling and transport. In: T. Grandin (Ed.), Livestock Handling and Transport, CABI, Wallingford, UK, pp. 43–61.

    Google Scholar 

  40. Burk, R.F., 1983. Biological activity of selenium. Annual Review of Nutrition 3, 53–70.

    CAS  PubMed  Google Scholar 

  41. Burke, J.M., Miller, J.E., Terrill, T.H., 2009. Impact of rotational grazing on management of gastrointestinal nematodes in weaned lambs. Veterinary Parasitology 163, 67–72.

    CAS  PubMed  Google Scholar 

  42. Cameron, R.E.B., Dyk, P.B., Herdt, T.H., Kaneene, J.B., Miller, R., Bucholtz, H.F., Liesman, J.S., Vandehaar, M.J., Emery, R.S., 1998. Dry cow diet, management, and energy balance as risk factors for displaced abomasum in high producing dairy herds. Journal of Dairy Science 81, 132–139.

    CAS  PubMed  Google Scholar 

  43. Cao, G., Prior, R.L., 1998. Comparison of different analytical methods for assessing total antioxidant capacity of human serum. Clinical Chemistry 44, 1309–1315.

    CAS  PubMed  Google Scholar 

  44. Cao, G., Alessio, H.M., Cutler, R.G., 1993. Oxygen-radical absorbance capacity assay for antioxidants. Free Radical Biology and Medicine 14, 303–311.

    CAS  PubMed  Google Scholar 

  45. Carlson, J.C., Wu, X.M., Sawada, M., 1993. Oxygen radicals and the control of ovarian corpus luteum function. Free Radical Biology and Medicine 14, 79–84.

    CAS  PubMed  Google Scholar 

  46. Carrillo-Vico, A., Lardone, P.J., Naji, L., Fernández-Santos, J.M., Martín-Lacave, I., Guerrero, J.M., Calvo, J.R., 2005. Beneficial pleiotropic actions of melatonin in an experimental model of septic shock in mice: regulation of pro-/anti-inflammatory cytokine network, protection against oxidative damage and anti-apoptotic effects. Journal of Pineal Research 39, 400–408.

    CAS  PubMed  Google Scholar 

  47. Carter, J.N., Gill, D.R., Krehbiel, C.R., Confer, A.W., Smith, R.A., Lalman, D.L., Claypool, P.L., McDowell, L.R., 2005. Vitamin E supplementation of newly arrived feedlot calves. Journal of Animal Science 83, 1924–1932.

    CAS  PubMed  Google Scholar 

  48. Castillo, C., Hernandez, J., Bravo, A., Lopez-Alonso, M., Pereira, V., Benedito, J.L., 2005. Oxidative status during late pregnancy and early lactation in dairy cows. The Veterinary Journal 169, 286–292.

    CAS  PubMed  Google Scholar 

  49. Castillo, C., Hernandez, J., Valverde, I., Pereira, V., Sotillo, J., Alonso, M.L., Benedito, J.L., 2006. Plasma malonaldehyde (MDA) and total antioxidant status (TAS) during lactation in dairy cows. Research in Veterinary Science 80, 133–139.

    CAS  PubMed  Google Scholar 

  50. Celi, P., Bush, D.R., 2010. Pregnancy, lambing and survival. In: D. Cottle, (Ed.), International Sheep and Wool Handbook, Nottingham University Press, UK, pp. 223–257.

    Google Scholar 

  51. Celi, P., Raadsma, H.W., 2009. The effects of Yerba Mate (Ilex paraguarensis) supplementation on the productive performance of lambs. Ruminant Physiology. Digestion, metabolism, and effects of nutrition on reproduction and welfare. Proceeding of the XIth International Symposium in Ruminant Physiology, Clermont-Ferrand, France, pp. 804–805.

    Google Scholar 

  52. Celi, P., Raadsma, H.W., 2010. The effects of Yerba Mate (Ilex paraguarensis) supplementation on the productive performance of lactating dairy cows. Animal Production Science 50, 339–344.

    CAS  Google Scholar 

  53. Celi, P., Di Trana, A., Quaranta, A., 2008. Metabolic profile and oxidative status in goats during the peripartum period. Australian Journal of Experimental Agriculture 48, 1004–1008

    CAS  Google Scholar 

  54. Celi, P., Eppleston, J., Armstrong, A., Watt, B., 2010. Selenium supplementation increases resistance and resilience of Merino weaners to intestinal parasite infection in a selenium deficient area. Animal Production Science 50, 688–692.

    CAS  Google Scholar 

  55. Celi, P., Merlo, M., Da Dalt, L., Stefani, A., Barbato, O., Gabai, G., 2011. Plasma advanced oxidised protein products (AOPP) as a novel indicator of late embryonic mortality in dairy cows. Reproduction Fertility and Development, http://www.publish.csiro.au/view/journals/dsp_journals_pip_abstract.cfm?nid=44&ver=1&pip=RD10268.

  56. Celi, P., Sullivan, M., Evans, D., 2010. The stability of the reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) tests on stored horse blood. The Veterinary Journal 183, 217–218.

    CAS  PubMed  Google Scholar 

  57. Celi, P., Trana, A.D., Claps, S., 2010. Effects of plane of nutrition on oxidative stress in goats during the peripartum period. The Veterinary Journal 184, 95–99.

    CAS  PubMed  Google Scholar 

  58. Chaiyotwittayakun, A., Erskine, R.J., Bartlett, P.C., Herdt, T.H., Sears, P.M., Harmon, R.J., 2002. The effect of ascorbic acid and L-histidine therapy on acute mammary inflammation in dairy cattle. Journal of Dairy Science 85, 60–67.

    CAS  PubMed  Google Scholar 

  59. Chew, B.P., Keller, H.F., Erb, R.E., Malven, P.V., 1977. Periparturient concentrations of prolactin, progesterone and the estrogens in blood plasma of cows retaining and not retaining fetal membranes. Journal of Animal Science 44, 1055–1060.

    CAS  PubMed  Google Scholar 

  60. Chirase, N.K., Greene, L.W., Purdy, C.W., Loan, R.W., Briggs, R.E., McDowell, L.R., 2001. Effect of environmental stressors on ADG, serum retinol and alpha-tocopherol concentrations, and incidence of bovine respiratory disease of feeder steers. Journal of Animal Science 79, 188.

    Google Scholar 

  61. Chirase, N.K., Greene, L.W., Purdy, C.W., Loan, R.W., Auvermann, B.W., Parker, D.B., Walborg, E.F., Stevenson, D.E., Xu, Y., Klaunig, J.E., 2004. Effect of transport stress on respiratory disease, serum antioxidant status, and serum concentrations of lipid peroxidation biomarkers in beef cattle. American Journal of Veterinary Research 65, 860–864.

    CAS  PubMed  Google Scholar 

  62. Colditz, I.G., Watson, D.L., Gray, G.D., Eady, S.J., 1996. Some relationships between age, immune responsiveness and resistance to parasites in ruminants. International Journal for Parasitology. Novel Approaches to the Control of Helminth Parasites of Livestock 26, 869–877.

    CAS  Google Scholar 

  63. Cole, D.J.A., 1990. Nutritional strategies to optimise reproduction in pigs. Journal of Reproduction and Fertility Suppl. 40, 67–82.

    CAS  PubMed  Google Scholar 

  64. Coop, R.L., Holmes, P.H., 1996. Nutrition and parasite interaction. International Journal of Parasitology. Novel Approaches to the Control of Helminth Parasites of Livestock. 26, 951–962.

    Google Scholar 

  65. Corongiu, F.P., Poli, G., Dianzani, M.U., Cheeseman, K.H., Slater, T.F., 1986. Lipid peroxidation and molecular damage to polyunsaturated fatty acids in rat liver. Recognition of two classes of hydroperoxides formed under conditions in vivo. Chemico-Biological Interactions 59, 147–155.

    CAS  PubMed  Google Scholar 

  66. Corrigan, C.J., Kay, A.B., 1992. T cells and eosinophils in the pathogenesis of asthma. Immunology Today 13, 501–507.

    CAS  PubMed  Google Scholar 

  67. Dawson, T.M., Dawson, V.L., 1995. Nitric oxide: actions and pathological roles. Neuroscientist 1, 7–18.

    CAS  Google Scholar 

  68. de Lamirande, E., Jiang, H., Zini, A., Kodama, H., Gagnon, C., 1997. Reactive oxygen species and sperm physiology. Reviews in Reproduction 2, 48–54.

    Google Scholar 

  69. Deaton, C.M., 2006. The role of oxidative stress in an equine model of human asthma. Redox Report 11, 46–52.

    CAS  PubMed  Google Scholar 

  70. Dennery, P.A., 2004. Role of redox in fetal development and neonatal diseases. Antioxidants & Redox Signaling 6, 147–153.

    CAS  Google Scholar 

  71. Descalzo, A.M., Insani, E.M., Biolatto, A., Sancho, A.M., García, P.T., Pensel, N.A., Josifovich, J.A., 2005. Influence of pasture or grain-based diets supplemented with vitamin E on antioxidant/oxidative balance of Argentine beef. Meat Science 70, 35–44.

    CAS  PubMed  Google Scholar 

  72. Di Giuseppe, D., Di Simplicio, P., Capecchi, P.L., Lazzerini, P.E., Pasini, F.l., 2003. Alteration in the redox state of plasma in heart-transplant patients with moderate hyperhomocysteinemia. Journal of Laboratory and Clinical Medicine 142, 21–28.

    PubMed  Google Scholar 

  73. Di Giuseppe, D., Frosali, S., Priora, R., Di Simplicio, F.C., Buonocore, G., Cellesi, C., Capecchi, P.L., Pasini, F.L., Lazzerini, P.E., Jakubowski, H., Di Simplicio, P., 2004. The effects of age and hyperhomocysteinemia on the redox forms of plasma thiols. Journal of Laboratory and Clinical Medicine 144, 235–245.

    PubMed  Google Scholar 

  74. Di Trana, A., Celi, P., Claps, S., Fedele, V., Rubino, R., 2006. The effect of hot season and nutrition on the oxidative status and metabolic profile in dairy goats during mid lactation. Animal Science 82, 717–722.

    Google Scholar 

  75. Dobryszycka, W., 1997. Biological functions of haptoglobin – new pieces to an old puzzle. European Journal of Clinical Chemistry and Clinical Biochemistry 35, 647–654.

    CAS  PubMed  Google Scholar 

  76. Drackley, J.K., 1999. Biology of dairy cows during the transition period: the final frontier. Journal of Dairy Science 82, 2259–2273.

    CAS  PubMed  Google Scholar 

  77. Dröge, W., 2002. Free radicals in the physiological control of cell function. Physiological Reviews 82, 47–95.

    PubMed  Google Scholar 

  78. Dröge, W., 2006. Redox regulation in anabolic and catabolic processes. Current Opinion in Clinical Nutrition & Metabolic Care 9, 190–195.

    Google Scholar 

  79. Dröge, W., Schulze-Osthoff, K., Mihm, S., Galter, D., Schenk, H., Eck, H.P., Roth, S., Gmunder, H., 1994. Functions of glutathione and glutathione disulfide in immunology and immunopathology. FASEB Journal 8, 1131–1138.

    PubMed  Google Scholar 

  80. Duff, G.C., Galyean, M.L., 2007. Board-invited review: recent advances in management of highly stressed, newly received feedlot cattle. Journal of Animal Science 85, 823–840.

    CAS  PubMed  Google Scholar 

  81. Ealy, A.D., Arechiga, C.F., Bray, D.R., Risco, C.A., Hansen, P.J., 1994. Effectiveness of short-term cooling and vitamin E for alleviation of infertility induced by heat stress in dairy cows. Journal of Dairy Science 77, 3601–3607.

    CAS  PubMed  Google Scholar 

  82. Eger, S., Drori, D., Kadoori, I., Miller, N., Schindler, H., 1985. Effects of selenium and vitamin E on incidence of retained placenta. Journal of Dairy Science 68, 2119–2122.

    CAS  PubMed  Google Scholar 

  83. Eiler, H., Hopkins, F.M., 1992. Bovine retained placenta: effects of collagenase and hyaluronidase on detachment of placenta. Biology of Reproduction 46, 580–585.

    CAS  PubMed  Google Scholar 

  84. Ekstrand-Hammarström, B., Österlund, C., Lilliehook, B., Bucht, A., 2006. Vitamin E down-modulates mitogen-activated protein kinases, nuclear factor-kB and inflammatory responses in lung epithelial cells. Clinical Experimental Immunology 147, 359–369.

    Google Scholar 

  85. Erdogan, H., Karapehlivan, M., Citil, M., Atakisi, O., Uzlu, E., Unver, A., 2008. Serum sialic acid and oxidative stress parameters changes in cattle with leptospirosis. Veterinary Research Communications 32, 333–339.

    CAS  PubMed  Google Scholar 

  86. Erskine, R.J., 1993. Nutrition and mastitis. Update on bovine mastitis. Veterinary Clinics of North America Food Animal Practice 9, 551–556.

    CAS  Google Scholar 

  87. Erskine, R.J., Eberhart, R.J., Hutchimon, L.J., 1987. Herd management and mastitis prevalence in high and low cell count dairy herds. Journal of American Veterinary Medical Association 190, 1411–1416.

    CAS  Google Scholar 

  88. Fan, J., Shek, P.N., Suntres, Z.E., Li, Y.H., Oreopoulos, G.D., Rotstein, O.D., 2000. Liposomal antioxidants provide prolonged protection against acute respiratory distress syndrome. Surgery 128, 332–338.

    CAS  PubMed  Google Scholar 

  89. Fang, Y.-Z., Yang, S., Wu, G., 2002. Free radicals, antioxidants, and nutrition. Nutrition 18, 872–879.

    CAS  PubMed  Google Scholar 

  90. Fialovà, L., Malbohan, I., Kalousova, M., Soukupova, J., Krofta, L., Štipek, S., Zima, T., 2006. Oxidative stress and inflammation in pregnancy. Scandinavian Journal of Clinical and Laboratory Investigtion 66, 121–128.

    Google Scholar 

  91. Fivaz, B.H., Hobson, C., Wellington, A.C., Williams, E.J., 1993. Influence of selenium supplementation on helminth burdens of marginally deficient suckling Angora goat kids. Small Ruminant Research 10, 75–79.

    Google Scholar 

  92. Flohe, L., Gunzler, W.A., Schock, H.H., 1973. Glutathione peroxidase: a selenoenzyme. FEBS Letters 32, 132–134.

    CAS  PubMed  Google Scholar 

  93. Frei, B., 1994. Natural Antioxidants in Human Health and Disease, Academic Press, San Diego, CA.

    Google Scholar 

  94. Frei, B., Stocker, R., Ames, B.N., 1988. Antioxidant defenses and lipid peroxidation in human blood plasma. Proceedings of the National Academy of Science USA 85, 9748–9752.

    CAS  Google Scholar 

  95. Fürll, M., Dabbagh, M.N., Fürll, B., Sattler,T., Spielmann C., 1999. Ätiologie und Prophylaxe von Reperfusionsschäden. Dtsch Tierärztl Wochenschr 106, 389–393.

    PubMed  Google Scholar 

  96. Fürll, M., Dabbagh, M.N., Kirbach, H., Nauruschat, C., Sattler, T., Wilken, H., 2003. The anti-oxidative state before and after a diagnosed abomasal displacement in cows. Acta Veterinaria Scandinavica 44(Suppl 1), P37.

    Google Scholar 

  97. Gaál, T., Ribiczeyné-Szabó, P., Stadler, K., Jakus, J., Reiczigel, J., Kövér, P., Mézes, M., Sümeghy, L., 2006. Free radicals, lipid peroxidation and the antioxidant system in the blood of cows and newborn calves around calving. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 143, 391–396.

    Google Scholar 

  98. Gabai, G., Testoni, S., Piccinini, R., Marinelli, L., Stradaioli, G., 2004. Oxidative stress in primiparous cows in relation to dietary starch and the progress of lactation. Animal Science 79, 99–108.

    Google Scholar 

  99. Galyean, M.L., Perino, L.J., Duff, G.C., 1999. Interaction of cattle health/immunity and nutrition. Journal of Animal Science 77, 1120–1134.

    CAS  PubMed  Google Scholar 

  100. Gatellier, P., Mercier, Y., Renerre, M., 2004. Effect of diet finishing mode (pasture or mixed diet) on antioxidant status of Charolais bovine meat. Meat Science 67, 385–394.

    CAS  PubMed  Google Scholar 

  101. Gazi, M.R., Yokota, M., Tanaka, Y., Kanda, S., Itabashis, H., 2007. Effects of protozoa on the antioxidant activity in the ruminal fluid and blood plasma of cattle. Animal Science Journal 78, 34–40.

    CAS  Google Scholar 

  102. Georgieva, N.V., 2005. Oxidative stress as a factor of disrupted ecological oxidative balance in biological systems – a review. Bulgarian Journal of Veterinary Medicine 8, 1–11.

    Google Scholar 

  103. Ghiselli, A., Serafini, M., Maiani, G., Azzini, E., Ferro-Luzzi, A., 1995. A fluorescence-based method for measuring total plasma antioxidant capability. Free Radical Biology and Medicine 18, 29–36.

    CAS  PubMed  Google Scholar 

  104. Ghiselli, A., Serafini, M., Natella, F., Scaccini, C., 2000. Total antioxidant capacity as a tool to assess redox status: critical view and experimental data. Free Radical Biology and Medicine 29, 1106–1114.

    CAS  PubMed  Google Scholar 

  105. Glantzounis, G.K., Tsimoyiannis, E.C., Kappas, A.M., Galaris, D.A., 2005. Uric acid and oxidative stress. Current Pharmaceutical Design 11, 4145–4151.

    CAS  PubMed  Google Scholar 

  106. Glass, E.J., Jensen, K., 2007. Resistance and susceptibility to a protozoan parasite of cattle – gene expression differences in macrophages from different breeds of cattle. Veterinary Immunology and Immunopathology. Disease Resistance and Immunity 120, 20–30.

    CAS  PubMed  Google Scholar 

  107. Goff, J.P., 2006. Major advances in our understanding of nutritional influences on bovine health. Journal of Dairy Science 89, 1292–1301.

    CAS  PubMed  Google Scholar 

  108. Goff, J.P., Stabel, J.R., 1990. Decreased plasma retinol, alpha-tocopherol, and zinc concentration during the periparturient period: effect of milk fever. Journal of Dairy Science 73, 3195–3199.

    CAS  PubMed  Google Scholar 

  109. Goff, J.P., Horst, R.L., Mueller, F.J., Miller, J.K., Kiess, G.A., Dowlen, H.H., 1991. Addition of chloride to a prepartal diet high in cations increases 1,25-dihydroxyvitamin D response to hypocalcemia preventing milk fever. Journal of Dairy Science 74, 3863–3871.

    CAS  PubMed  Google Scholar 

  110. Goff, W.L., Carl Johnson, W., Wyatt, C.R., Cluff, C.W., 1996. Assessment of bovine ­mononuclear phagocytes and neutrophils for induced L-arginine-dependent nitric oxide ­production. Veterinary Immunology and Immunopathology 55, 45–62.

    CAS  PubMed  Google Scholar 

  111. Grandin, T., 1997. Assessment of stress during handling and transport. Journal of Animal Science 75, 249–257.

    CAS  PubMed  Google Scholar 

  112. Grewal, A., Ahuja, C.S., Singha, S.P.S., Chaudhary, K.C., 2005. Status of lipid peroxidation, some antioxidant enzymes and erythrocytic fragility of crossbred cattle naturally infected with Theileria annulata. Veterinary Research Communications 29, 387–394.

    CAS  PubMed  Google Scholar 

  113. Griffiths, H.R., Møller, L., Bartosz, G., Bast, A., Bertoni-Freddari, C., Collins, A., Cooke, M., Coolen, S., Haenen, G., Hoberg, A.-M., Loft, S., Lunec, J., Olinski, R., Parry, J., Pompella, A., Poulsen, H., Verhagen, H., Astley, S.B., 2002. Biomarkers. Molecular Aspects of Medicine 23, 101–208.

    CAS  PubMed  Google Scholar 

  114. Grunert, E., Ahlers, D., Heuwieser, W., 1989. The role of endogenous estrogens in the maturation process of the bovine placenta. Theriogenology 31, 1081–1091.

    CAS  PubMed  Google Scholar 

  115. Gu, B., Zhu, Y., Zhu, W., Miao, J., Deng, Y.E., Zou, S., 2009. Retinoid protects rats against neutrophil-induced oxidative stress in acute experimental mastitis. International Immunopharmacology 9, 223–229.

    CAS  PubMed  Google Scholar 

  116. Guerin, P., El Mouatassim, S., Menezo, Y., 2001. Oxidative stress and protection against reactive oxygen species in the pre-implantation embryo and its surroundings. Human Reproduction Update 7, 175–189.

    CAS  PubMed  Google Scholar 

  117. Haider, M.J., 1992. Hematological study of water buffalo (Bubalus bubalis) during theileriosis (Theileria annulata). Annals of the New York Academy of Sciences 653, 191–193.

    CAS  PubMed  Google Scholar 

  118. Halliwell, B., 1988. Albumin – an important extracellular antioxidant. Biochemical Pharmacology 37, 569–571.

    CAS  PubMed  Google Scholar 

  119. Halliwell, B., Chirico, S., 1993. Lipid peroxidation: its mechanism, measurement, and significance. American Journal of Clinical Nutrition 57, 715S–725S.

    CAS  PubMed  Google Scholar 

  120. Halliwell, B., Gutteridge, J.M.C., 1989. Free Radicals in Biology and Medicine, Oxford University Press, Oxford, UK.

    Google Scholar 

  121. Hansen, P.J., Soto, P., Natzke, R.P., 2004. Mastitis and fertility in cattle – possible involvement of inflammation or immune activation in embryonic mortality. American Journal of Reproductive Immunology 51, 294–301.

    PubMed  Google Scholar 

  122. Harrison, J.H., Hancock, D.D., Conrad, H.R., 1984. Vitamin E and selenium for reproduction of the dairy cow. Journal of Dairy Science 67, 123–132.

    CAS  PubMed  Google Scholar 

  123. Hartung, J., 2003. Effects of transport on health of farm animals. Veterinary Research Communications 27, 525–527.

    PubMed  Google Scholar 

  124. Herdt,T.H., 2000. Ruminant adaptation to negative energy balance: influences on the etiology of ketosis and fatty liver. Veterinary Clinics of North America Food Animal Practice 16, 215–231.

    CAS  Google Scholar 

  125. Hermes-Lima, M., Storey, J.M., Storey, K.B., 1988. Antioxidants defenses and metabolic depression. The hypothesis of preparation for oxidative stress in land snails. Comparative Biochemistry and Physiology B, Biochemistry and Molecular Biology 120, 437–448.

    Google Scholar 

  126. Hogan, J.S., Smith, K.L., Weiss, W.P., Todhunter, D.A., Schockey, W.L., 1990. Relationships among vitamin E, selenium, and bovine blood neutrophils. Journal of Dairy Science 73, 2372–2378.

    CAS  PubMed  Google Scholar 

  127. Hogan, J.S., Weiss, W.P., Smith, K.L., 1993. Role of vitamin E and selenium in host defense against mastitis. Journal of Dairy Science 76, 2795–2803.

    CAS  PubMed  Google Scholar 

  128. Hopkins, G.J., Roberts, J., Evans, J.V., 1975. Red blood cell concentrations of reduced glutathione and potassium as biochemical markers of wool growth in Merino sheep. Journal of Agricultural Science 84, 481–486.

    Google Scholar 

  129. Hoste, H., Torres-Acosta, J.F., Aguilar-Caballero, A.J., 2008. Nutrition–parasite interactions in goats: is immunoregulation involved in the control of gastrointestinal nematodes? Parasite Immunology 30, 79–88.

    CAS  PubMed  Google Scholar 

  130. Hostetler, C.E., Kincaid, R.L., Mirando, M.A., 2003. The role of essential trace elements in embryonic and fetal development in livestock. Veterinary Journal 166, 125–139.

    CAS  Google Scholar 

  131. Huie, R.E., Padmaja, S., 1993. The reaction of no with superoxide. Free Radical Research 18, 195–199.

    CAS  Google Scholar 

  132. Huntley, J.F., Patterson, M., Mackellar, A., Jackson, F., Stevenson, L.M., Coop, R.L., 1995. A comparison of the mast cell and eosinophil responses of sheep and goats to gastrointestinal nematode infections. Research in Veterinary Science 58, 5–10.

    CAS  PubMed  Google Scholar 

  133. Inanami, O., Shiga, A., Okada, K., 1999. Lipid peroxides and antioxidants in serum of neonatal calves. American Journal of Veterinary Research 60, 452–457.

    CAS  PubMed  Google Scholar 

  134. Ingvartsen, K.L., Andersen, J.B., 2000. Integration of metabolism and intake regulation: a review focusing on periparturient animals. Journal of Dairy Science 83, 1573–1597.

    CAS  PubMed  Google Scholar 

  135. Jain, S.K., McVie, R., 1999. Hyperketonemia can increase lipid peroxidation and lower glutathione levels in human erythrocytes in vitro and in type 1 diabetic patients. Diabetes 48, 1850–1855.

    CAS  PubMed  Google Scholar 

  136. Janero, D.R., 1990. Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. Free Radical Biology and Medicine 9, 515–540.

    CAS  PubMed  Google Scholar 

  137. Jelinek, P.D., Ellis, T., Wroth, R.H., Sutherland, S.S., Masters, H.G., Petterson, D.S., 1988. The effect of selenium supplementation on immunity, and the establishment of an experimental Haemonchus contortus infection, in weaner Merino sheep fed a low selenium diet. Australian Veterinary Journal 65, 214–217.

    CAS  PubMed  Google Scholar 

  138. Jobgen, W.S., Fried, S.K., Fu, W.J., Meininger, C.J., Wu, G., 2006. Regulatory role for the arginine-nitric oxide pathway in metabolism of energy substrates. The Journal of Nutritional Biochemistry 17, 571–588.

    CAS  PubMed  Google Scholar 

  139. Julien, W.E., Conrad, H.R., Jones, J.E., Moxon, A.L., 1976. Selenium and vitamin E and incidence of retained placenta in parturient dairy cows. Journal of Dairy Science 59, 1954–1959.

    CAS  PubMed  Google Scholar 

  140. Kalousová, M., Skrha, J., Zima, T., 2002. Advanced glycation end products and advanced oxidation protein products in patients with diabetes mellitus. Physiological Research 51, 597–604.

    PubMed  Google Scholar 

  141. Kalousová, M., Zima, T., Tesar, V., Dusilová-Sulková, S., Skrha, J., 2005. Advanced glycoxidation end products in chronic diseases – clinical chemistry and genetic background. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis Inflammation, cellular and redox signalling mechanisms in cancer and degenerative diseases 579, 37–46.

    Google Scholar 

  142. Kaneda, H., Taguchi, J., Ogasawara, K., Aizawa, T., Ohno, M., 2002. Increased level of advanced oxidation protein products in patients with coronary artery disease. Atherosclerosis 162, 221–225.

    CAS  PubMed  Google Scholar 

  143. Kankofer, M., 1999. The enzymes responsible for the metabolism of prostaglandins in bovine placenta. Prostaglandins, Leukotrienes and Essential Fatty Acids 61, 359–362.

    CAS  Google Scholar 

  144. Kankofer, M., 2001. Antioxidative defence mechanisms against reactive oxygen species in bovine retained and not-retained placenta: activity of glutathione peroxidase, glutathione transferase, catalase and superoxide dismutase. Placenta 22, 466–472.

    CAS  PubMed  Google Scholar 

  145. Kankofer, M., 2001. The levels of lipid peroxidation products in bovine retained and not retained placenta. Prostaglandins, Leukotrienes and Essential Fatty Acids 64, 33–36.

    CAS  Google Scholar 

  146. Kankofer, M., 2002. 8-iso-prostaglandin F2[alpha] as a marker of tissue oxidative damage in bovine retained placenta. Prostaglandins & Other Lipid Mediators 70, 51–59.

    CAS  Google Scholar 

  147. Kankofer, M., 2002. Placental release/retention in cows and its relation to peroxidative damage of macromolecules. Reproduction in Domestic Animals 37, 27–30.

    CAS  PubMed  Google Scholar 

  148. Kankofer, M., Wiercinski, J., 1999. Prostaglandin E29-keto reductase from bovine term placenta. Prostaglandins, Leukotrienes and Essential Fatty Acids 61, 29–32.

    CAS  Google Scholar 

  149. Kankofer, M., Wierci, Å., Ski, J., Fidecki, M., 1998. Activity of hyaluronidase in placental tissues from cows with and without retained fetal membranes. Journal of Veterinary Medicine Series A: Physiology Pathology Clinical Medicine 45, 337–341.

    CAS  Google Scholar 

  150. Kankofer, M., Wiercinski, J., Zerbe, H., 2000. Activity of placental ß-N-acetyl-glucosaminidase in cows with and without retained foetal membranes. Reproduction in Domestic Animals 35, 97–100.

    CAS  Google Scholar 

  151. Kankofer, M., Lipko, J., Zdunczyk, S., 2005. Total antioxidant capacity of bovine ­spontaneously released and retained placenta. Pathophysiology 11, 215–219.

    CAS  PubMed  Google Scholar 

  152. Kappel, L.C., Ingraham, R.H., Morgan, E.B., Dixon, J.M., Zeringue, L., Wilson, D., Babcock, D.K., 1984. Selenium concentrations in feeds and effects of treating pregnant Holstein cows with selenium and vitamin E on blood selenium values and reproductive performance. American Journal of Veterinary Research 45, 691–694.

    CAS  PubMed  Google Scholar 

  153. Kato, H., Sugino, N., Takiguchi, S., Kashida, S., Nakamura, Y., 1997. Roles of reactive oxygen species in the regulation of luteal function. Reviews of Reproduction 2, 81–83.

    CAS  PubMed  Google Scholar 

  154. Kawabata, K., Hagio, T., Matsuoka, S., 2002. The role of neutrophil elastase in acute lung injury. European Journal of Pharmacology 451, 1–10.

    CAS  PubMed  Google Scholar 

  155. Kehrer, J.P., Lund, L.G., 1994. Cellular reducing equivalents and oxidative stress. Free Radical Biology and Medicine 17, 65–75.

    CAS  PubMed  Google Scholar 

  156. Kehrer, J.P., Smith., C.V., 1994. Free radicals in biology: sources, reactivities, and roles in the etiology of human dieseases. In: B. Frei (Ed.), Natural Antioxidants in Human Health and Diseases, Academic Press, San Diego, CA, pp. 25–62.

    Google Scholar 

  157. Kim, Y.G., Jeon, D.Y., Yang, M.K., 1997. Superoxide dismutase activity and lipid peroxidation in the liver of guinea pig infected with Leptospira interrogans. Free Radical Research 26, 1–6.

    CAS  PubMed  Google Scholar 

  158. Kleczkowski, M., Klucinski, W., Shaktur, A., Sikora, J., 2005. Concentration of ascorbic acid in the blood of cows with subclinical mastitis. Polish Journal of Veterinary Sciences 8, 121–125.

    CAS  PubMed  Google Scholar 

  159. Knaapen, A.M., Seiler, F., Schilderman, P.A.E.L., Nehls, P., Bruch, J., Schins, R.P.F., Borm, P.J.A., 1999. Neutrophils cause oxidative DNA damage in alveolar epithelial cells. Free Radical Biology and Medicine 27, 234–240.

    CAS  PubMed  Google Scholar 

  160. Knowles, T.G., 1998. A review of the road transport of slaughter sheep. Veterinary Record 143, 212–219.

    CAS  PubMed  Google Scholar 

  161. Knowles, T.G., 1999. A review of the road transport of cattle. Veterinary Record 144, 197–201.

    CAS  PubMed  Google Scholar 

  162. Komine, K.-i., Kuroishi, T., Komine, Y., Watanabe, K., Kobayashi, J., Yamaguchi, T., Kamata, S.-i., Kumagai, K., 2004. Induction of nitric oxide production mediated by tumor necrosis factor alpha on staphylococcal enterotoxin c-stimulated bovine mammary gland cells. Clinical and Diagnostic Laboratory Immunology 11, 203–210.

    CAS  PubMed Central  PubMed  Google Scholar 

  163. Laven, R.A., Drew, S.B., 1999. Dietary protein and the reproductive performance of cows. Veterinary Record 145, 687–695.

    CAS  PubMed  Google Scholar 

  164. LeBlanc, S.J., 2008. Postpartum uterine disease and dairy herd reproductive performance:a review. The Veterinary Journal. Production Diseases of the Transition Cow 176, 102–114.

    Google Scholar 

  165. LeBlanc, S.J., Herdt, T.H., Seymour, W.M., Duffield, T.F., Leslie, K.E., 2004. Peripartum serum vitamin E, retinol, and beta-carotene in dairy cattle and their associations with disease. Journal of Dairy Science 87, 609–619.

    CAS  PubMed  Google Scholar 

  166. Leidl, W., Hegner, D., Rockel, P., 1980. Investigations on the PGF2a concentration in maternal and foetal cotyledons of cows with and without retained foetal membranes. Journal of Veterinary Medicine A 27, 691.

    CAS  Google Scholar 

  167. Levett, P.N., 2001. Leptospirosis. Clinical Microbiology Reviews 14, 296–326.

    CAS  PubMed Central  PubMed  Google Scholar 

  168. Liebler, D.C., 1993. The role of metabolism in the antioxidant function of vitamin E. Critical Reviews in Toxicology 23, 147–169.

    CAS  PubMed  Google Scholar 

  169. Lightbody, J.H., Stevenson, L.M., Jackson, F., Donaldson, K., Jones, D.G., 2001. Comparative aspects of plasma antioxidant status in sheep and goats, and the influence of experimental abomasal nematode infection. Journal of Comparative Pathology 124, 192–199.

    CAS  PubMed  Google Scholar 

  170. Liu, S.M., Eady, S.J., 2005. Glutathione: its implications for animal health, meat quality, and health benefits of consumers. Australian Journal of Agricultural Research 56, 775–780.

    CAS  Google Scholar 

  171. Liu, S.M., Masters, D.G., 2000. Quantitative analysis of methionine and cysteine requirements for wool production of sheep. Animal Science 71, 175–185.

    CAS  Google Scholar 

  172. Lohrke, B., Viergutz, T., Kanitz, W., Gollnitz, K., Becker, F., Hurtienne, A., Schweigert, F.J., 2004. High milk yield in dairy cows associated with oxidant stress. Online Journal of Veterinary Research 8, 70–78.

    Google Scholar 

  173. Lykkesfeldt, J., 2001. Determination of malondialdehyde as dithiobarbituric acid adduct in biological samples by HPLC with fluorescence detection: comparison with ultraviolet-visible spectrophotometry. Clinical Chemistry 47, 1725–1727.

    CAS  PubMed  Google Scholar 

  174. Lykkesfeldt, J., Svendsen, O., 2007. Oxidants and antioxidants in disease: oxidative stress in farm animals. The Veterinary Journal 173, 502–511.

    CAS  PubMed  Google Scholar 

  175. Maciel, E.A.P., Athanazio, D.A., Reis, E.A.G., Cunha, F.Q., Queiroz, A., Almeida, D., McBride, A.J.A., Ko, A.I., Reis, M.G., 2006. High serum nitric oxide levels in patients with severe leptospirosis. Acta Tropica 100, 256–260.

    CAS  PubMed Central  PubMed  Google Scholar 

  176. MacMicking, J., Xie, Q.-w., Nathan, C., 1997. Nitric oxide and macrophage function. Annual Review of Immunology 15, 323–350.

    CAS  PubMed  Google Scholar 

  177. Makkar, H.P.S., Francis, G., Becker, K., 2007. Bioactivity of phytochemicals in some lesser-known plants and their effects and potential applications in livestock and aquaculture production systems. Animal 1, 1371–1391.

    CAS  PubMed  Google Scholar 

  178. Martin, G.B., Kadokawa, H., 2006. “Clean, green and ethical” animal production. Case study: reproductive efficiency in small ruminants. The Journal of Reproduction and Development 52, 145–152.

    PubMed  Google Scholar 

  179. McClelland, G.B., 2004. Fat to the fire: the regulation of lipid oxidation with exercise and environmental stress. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. Special Issue Dedicated to the Memory of Peter W. Hochachka (1937–2002) 139, 443–460.

    Google Scholar 

  180. McEvoy, T.G., Robinson, J.J., Aitken, R.P., Findlay, P.A., Robertson, I.S., 1997. Dietary excesses of urea influence the viability and metabolism of preimplantation sheep embryos and may affect fetal growth among survivors. Animal Reproduction Science 47, 71–90.

    CAS  PubMed  Google Scholar 

  181. McNaughton, A.P., Murray, R.D., 2009. Structure and function of the bovine fetomaternal unit in relation to the causes of retained fetal membranes. Vetetinary Record 165, 615–622.

    CAS  Google Scholar 

  182. Merlo, M., Barbato, O., Stefani, A., Celi, P., Da Dalt, L., Gabai, G., 2008. Embryonic mortality and plasma advanced oxidation protein products (AOPP) increase in dairy cows. Current Topics in Dairy Production, Proceedings of the Dairy Research Foundation Symposium, Camden, Australia, pp. 49–53.

    Google Scholar 

  183. Merlo, M., Celi, P., Barbato, O., Gabai, G., 2008. Relationships between oxidative status and pregnancy outcome in dairy cows. Animal Production in Australia 27, 84.

    Google Scholar 

  184. Miller, J.K., Brzezinska-Slebodzinska, E., Madsen, F.C., 1993. Oxidative stress, antioxidants, and animal function. Journal of Dairy Science 76, 2812–2823.

    CAS  PubMed  Google Scholar 

  185. Miller, N.J., Rice-Evans, C., Davies, M.J., Gopinathan, V., Milner, A., 1993. A novel method for measuring antioxidant capacity and its application to monitoring the antioxidant status in premature neonates. Clinical Science 84, 407–412.

    CAS  PubMed  Google Scholar 

  186. Miller, J.K., Brzezinska-Slebodzinska, E., Campbell, M.H., Mosley, S.A., Holt, J.A., 1999. Vitamin and mineral involvement in antioxidants. Proceedings of the 50th California Animal Nutrition Conference, Fresno, 79–85.

    Google Scholar 

  187. Milne, G.L., Musiek, E.S., Morrow, J.D., 2005. F2-Isoprostanes as markers of oxidative stress in vivo: an overview. Biomarkers 10, 10–23.

    Google Scholar 

  188. Moilanen, E., Vapaatalo, H., 1995. Nitric oxide in inflammation and immune response. Annals of Medicine 27, 359–367.

    CAS  PubMed  Google Scholar 

  189. Moran, L.K., Gutteridge, J., Quinlan, G.J., 2001. Thiols in cellular redox signalling and control. Current Medicinal Chemistry 8, 763.

    CAS  PubMed  Google Scholar 

  190. Morrison, I.W., 2009. Progress towards understanding the immunobiology of Theileria parasites. Parasitology 136, 1415–1426.

    PubMed  Google Scholar 

  191. Mudron, P., Rehage, J., Qualmann, K., Sallmann, H.P., Scholz, H., 1999. A study of lipid peroxidation and vitamin E in dairy cows with hepatic insufficiency. Journal of Veterinary Medicine A 46, 219–224.

    CAS  Google Scholar 

  192. Mukherjee, R., 2008. Selenium and vitamin E increases polymorphonuclear cell phagocytosis and antioxidant levels during acute mastitis in riverine buffaloes. Veterinary Research Communications 32, 305–313.

    PubMed  Google Scholar 

  193. Mulligan, F.J., Doherty, M.L., 2008. Production diseases of the transition cow. The Veterinary Journal 176, 3–9.

    CAS  PubMed  Google Scholar 

  194. Musicki, B., Aten, R., Behrman, H., 1994. Inhibition of protein synthesis and hormone-sensitive steroidogenesis in response to hydrogen peroxide in rat luteal cells. Endocrinology 134, 588–595.

    CAS  PubMed  Google Scholar 

  195. Naresh, R., Dwivedi, S.K., Swarup, D., Patra, R.C., 2002. Evaluation of ascorbic acid ­treatment in clinical and subclinical mastitis of Indian dairy cows. Asian-Australasian Journal of Animal Science 15, 905–911.

    CAS  Google Scholar 

  196. Naziroglu, M., Åžaki, C.E., Sevgili, M., 1999. The effect of buparvaquone treatment on the levels of some antioxidant vitamins, lipid peroxidation and glutathione peroxidase in cattle with theileriosis. Journal of Veterinary Medicine, Series B 46, 233–239.

    CAS  Google Scholar 

  197. Ness, R.B., 2004. The consequences for human reproduction of a robust inflammatory response. The Quarterly Review of Biology 79, 383–393.

    PubMed  Google Scholar 

  198. Nockels, C.F., Odde, K.G., Craig, A.M., 1996. Vitamin E supplementation and stress affect tissue alpha-tocopherol content of beef heifers. Journal of Animal Science 74, 672–677.

    CAS  PubMed  Google Scholar 

  199. Norman, J.E., Thomson, A.J., Telfer, J.F., Young, A., Greer, I.A., Cameron, I.T., 1999. Myometrial constitutive nitric oxide synthase expression is increased during human ­pregnancy. Molecular Human Reproduction 5, 175–181.

    CAS  PubMed  Google Scholar 

  200. Notebaert, S., Demon, D., Vanden Berghe, T., Vandenabeele, P., Meyer, E., 2008. Inflammatory mediators in Escherichia coli-induced mastitis in mice. Comparative Immunology, Microbiology and Infectious Diseases 31, 551–565.

    PubMed  Google Scholar 

  201. Noyan, T., Güler, A., Sekeroglu, M.R., Kamaci, M., 2006. Serum advanced oxidation protein products, myeloperoxidase and ascorbic acid in pre-eclampsia and eclampsia. Australian and New Zealand Journal of Obstetrics and Gynaecology 46, 486–491.

    PubMed  Google Scholar 

  202. O’Flaherty, C.M., Beorlegui, N.B., Beconi, M.T., 1999. Reactive oxygen species ­requirements for bovine sperm capacitation and acrosome reaction. Theriogenology 52, 289–301.

    PubMed  Google Scholar 

  203. O’Flaherty, C., Beorlegui, N., Beconi, M.T., 2003. Participation of superoxide anion in the capacitation of cryopreserved bovine sperm. International Journal of Andrology 26, 109–114.

    PubMed  Google Scholar 

  204. Okamoto, T., Akaike, T., Nagano, T., Miyajima, S., Suga, M., Ando, M., Ichimori, K., Maeda, H., 1997. Activation of human neutrophil procollagenase by nitrogen dioxide and peroxynitrite: a novel mechanism for procollagenase activation involving nitric oxide. Archives of Biochemistry and Biophysics 342, 261–274.

    CAS  PubMed  Google Scholar 

  205. Owens, F.N., Secrist, D.S., Hill, W.J., Gill, D.R., 1998. Acidosis in cattle: a review. Journal of Animal Science 76, 275–286.

    CAS  PubMed  Google Scholar 

  206. Ozawa, M., Nagai, T., Fahrudin, M., Karja, N.W.K., Kaneko, H., Noguchi, J., Ohnuma, K., Kikuchi, K., 2006. Addition of glutathione or thioredoxin to culture medium reduces intracellular redox status of porcine IVM/IVF embryos, resulting in improved development to the blastocyst stage. Molecular Reproduction and Development 73, 998–1007.

    CAS  PubMed  Google Scholar 

  207. Paula-Lopes, F.F., Al-Katanani, Y.M., Majewski, A.C., McDowell, L.R., Hansen, P.J., 2003. Manipulation of antioxidant status fails to improve fertility of lactating cows or survival of heat-shocked embryos. Journal of Dairy Science 86, 2343–2351.

    CAS  PubMed  Google Scholar 

  208. Pedernera, M., Celi, P., García, S.C., Salvin, H.E., Barchia, I., Fulkerson, W.J., 2010. Effect of diet, energy balance and milk production on oxidative stress in early-lactating dairy cows grazing pasture. The Veterinary Journal 186, 352–357.

    CAS  PubMed  Google Scholar 

  209. Perl, A., Gergely, P., Puskas, F., Banki, K., 2002. Metabolic switches of T-cell activation and apoptosis. Antioxidants & Redox Signaling 4, 427–443.

    CAS  Google Scholar 

  210. Petreccia, D.C., Nauseef, W.M., Clark, R.A., 1987. Respiratory burst of normal human eosinophils. Journal of Leukocyte Biology 41, 283–288.

    CAS  PubMed  Google Scholar 

  211. Pregel, P., Bollo, E., Cannizzo, F., Biolatti, B., Contato, E., Biolatti, P., 2005. Antioxidant capacity as a reliable marker of stress in dairy calves transported by road. Veterinary Record 156, 53–54.

    CAS  PubMed  Google Scholar 

  212. Radi, R., Beckman, J.S., Bush, K.M., Freeman, B.A., 1991. Peroxynitrite-induced membrane lipid peroxidation: the cytotoxic potential of superoxide and nitric oxide. Archives of Biochemistry and Biophysics 288: 481–487.

    CAS  PubMed  Google Scholar 

  213. Ranjan, R., Swarup, D., Naresh, R., Patra, R.C., 2005. Enhanced erythrocytic lipid peroxides and reduced plasma ascorbic acid, and alteration in blood trace elements level in dairy cows with mastitis. Veterinary Research Communication 29, 27–34.

    CAS  Google Scholar 

  214. Reilly, P.M., Schiller, H.J., Bulkley, G.B., 1991. Pharmacologic approach to tissue injury mediated by free radicals and other reactive oxygen metabolites. The American Journal of Surgery 161, 488–503.

    CAS  Google Scholar 

  215. Reynolds, L.P., Borowicz, P.P., Vonnahme, K.A., Johnson, M.L., Grazul-Bilska, A.T., Redmer, D.A., Caton, J.S., 2005. Placental angiogenesis in sheep models of compromised pregnancy. Journal of Physiology 565, 43–58.

    CAS  PubMed  Google Scholar 

  216. Riollet, C., Rainard, P., Poutrel, B., 2000. Differential induction of complement fragment C5a and inflammatory cytokines during intramammary infections with Escherichia coli and Staphylococcus aureus. Clincal and Diagnostic Laboratory Immunology 7, 161–167.

    CAS  Google Scholar 

  217. Rivera, J.D., Duff, G.C., Galyean, M.L., Walker, D.A., Nunnery, G.A., 2002. Effects of supplemental vitamin E on performance, health, and humoral immune response of beef cattle. Journal of Animal Science 80, 933–941.

    CAS  PubMed  Google Scholar 

  218. Rivera, M.T., Souza, A.P.D., Araujo-Jorge, T.C., De Castro, S.L., Vanderpas, J., 2003. Trace elements, innate immune response and parasites. Clinical Chemistry and Laboratory Medicine 41, 1020–1025.

    CAS  PubMed  Google Scholar 

  219. Rizzo, A., Mutinati, M., Spedicato, M., Minoia, G., Trisolini, C., Jirillo, F., Sciorsci, R.L., 2008. First demonstration of an increased serum level of reactive oxygen species during the peripartal period in the Ewes. Immunopharmacology and Immunotoxicology 30, 741–746.

    CAS  PubMed  Google Scholar 

  220. Robson, S., Plant, J.W., 2007. Selenium deficiency in sheep. Primefact 471 (NSW Department of Primary Industries), http://www.dpi.nsw.gov.au/agriculture/livestock/sheep/health/selenium-deficiency-sheep.

  221. Rocksen, D., Ekstrand-Hammarstrom, B., Johansson, L., Bucht, A., 2003. Vitamin E reduces transendothelial migration of neutrophils and prevents lung injury in endotoxin-induced airway inflammation. American Journal of Respiratory Cell Molecular Biology 28, 199–207.

    CAS  PubMed  Google Scholar 

  222. Rosselli, M., Dubey, R., Imthurn, B., Macas, E., Keller, P., 1995. Effects of nitric oxide on human spermatozoa: evidence that nitric oxide decreases sperm motility and induces sperm toxicity. Human Reproduction 10, 1786–1790.

    CAS  PubMed  Google Scholar 

  223. Rosselli, M., Dubey, R., Rosselli, M., Macas, E., Fink, D., Lauper, U., Keller, P., Imthurn, B., 1996. Identification of nitric oxide synthase in human and bovine oviduct. Molecular Human Reproduction 2, 607–612.

    CAS  PubMed  Google Scholar 

  224. Rosselli, M., Keller, P., Dubey, R., 1998. Role of nitric oxide in the biology, physiology and pathophysiology of reproduction. Human Reproduction Update 4, 3–24.

    CAS  PubMed  Google Scholar 

  225. Rueda, B., Tilly, K., Hansen, T., Hoyer, P., Tilly, J., 1995. Expression of superoxide ­dismutase, catalase and glutathione peroxidase in the bovine corpus luteum: evidence ­supporting a role for oxidative stress in luteolysis. Endocrine 3, 227–232.

    CAS  PubMed  Google Scholar 

  226. Sahoo, S., Patra, R., Behera, P., Swarup, D., 2009. Oxidative stress indices in the erythrocytes from lactating cows after treatment for subclinical ketosis with antioxidant incorporated in the therapeutic regime. Veterinary Research Communications 33, 281–290.

    CAS  PubMed  Google Scholar 

  227. Sakatani, M., Yamanaka, K., Kobayashi, S., Takahashi, M., 2008. Heat shock-derived reactive oxygen species induce embryonic mortality in in vitro early stage bovine embryos. Journal of Reproduction and Development 54, 496–501.

    CAS  PubMed  Google Scholar 

  228. Saluja, P.S., Gupta, S.L., Malhotra, D.V., Ambawat, H.K., 1999. Status of plasma malondialdehyde in experimental theileria annulata infection in crossbred bovine calves. Indian Veterinary Journal 76, 379–381.

    CAS  Google Scholar 

  229. Sauberlich, H.E., 1994. Pharmacology of vitamin C. Annual Reviews in Nutrition 14, 371–391.

    CAS  Google Scholar 

  230. Sawada, M., Carlson, J.C., 1991. Rapid plasma membrane changes in superoxide radical formation, fluidity, and phospholipase A2 activity in the Corpus luteum of the rat during induction of luteolysis. Endocrinology 128, 2992–2998.

    CAS  PubMed  Google Scholar 

  231. Sawada, M., Carlson, J.C., 1994. Studies on the mechanism controlling generation of superoxide radical in luteinised rat ovaries during regression. Endocrinology 135, 1645–1650.

    CAS  PubMed  Google Scholar 

  232. Scaletti, R.W., Trammell, D.S., Smith, B.A., Harmon, R.J., 2003. Role of dietary copper in enhancing resistance to Escherichia coli Mastitis. Journal of Dairy Science 86, 1240–1249.

    CAS  PubMed  Google Scholar 

  233. Schingoethe, D.J., Kirkbride, C.A., Palmer, I.S., Owens, M.J., Tucker, W.L., 1982. Response of cows consuming adequate selenium to vitamin E and selenium supplementation prepartum. Journal of Dairy Science 65, 2338–2344.

    CAS  PubMed  Google Scholar 

  234. Schwarz, K.B., 1996. Oxidative stress during viral infection: a review. Free Radical Biology and Medicine 21, 641–649.

    CAS  PubMed  Google Scholar 

  235. Sconberg, S., Nockels, C.F., Bennet, D.W., Bruyninclese, W., Blancquaret, A.M.B., Craig, A.M., 1993. Effect of shipping handling, adrenocortiocotropic hormone and epinephrine on L-tocopherol content of bovine blood. American Journal of Veterinary Research 54, 1287–1293.

    CAS  PubMed  Google Scholar 

  236. Segerson, E.C., Riviere, G.J., Dalton, H.L., Whitacre, M.D., 1981. Retained placenta of holstein cows treated with selenium and vitamin E. Journal of Dairy Science 64, 1833–1836.

    CAS  PubMed  Google Scholar 

  237. Selkirk, M.E., Smith, V.P., Thomas, G.R., Gounaris, K., 1998. Resistance of filarial nematode parasites to oxidative stress. International Journal for Parasitology 28, 1315–1332.

    CAS  PubMed  Google Scholar 

  238. Sengoku, K., Tamate, K., Yoshida, T., Takaoka, Y., Miyamoto, T., Ishikawa, M., 1998. Effects of low concentrations of nitric oxide on the zona pellucida binding ability of human spermatozoa. Fertility and Sterility 69, 522–527.

    CAS  PubMed  Google Scholar 

  239. Sharma, R., Agarwal, A., 2004. Role of reactive oxygen species in gynecologic diseases. Reproductive Medicine and Biology 3, 177–199.

    CAS  Google Scholar 

  240. Shi, W., Meininger, C., Haynes, T., Hatakeyama, K., Wu, G., 2004. Regulation of tetrahydrobiopterin synthesis and bioavailability in endothelial cells. Cell Biochemistry and Biophysics 41, 415–433.

    CAS  PubMed  Google Scholar 

  241. Shi, X.Y., Hou, F.F., Niu, H.X., Wang, G.B., Xie, D., Guo, Z.J., Zhou, Z.M., Yang, F., Tian, J.W., Zhang, X., 2008. Advanced oxidation protein products promote inflammation in diabetic kidney through activation of renal nicotinamide adenine dinucleotide phosphate oxidase. Endocrinology 149, 1829–1839.

    CAS  PubMed  Google Scholar 

  242. Shimamura, K., Sugino, N., Yoshida, Y., Nakamura, Y., Ogino, K., Kato, H., 1995. Changes in lipid peroxide and antioxidant enzyme activities in corpora lutea during pseudopregnancy in rats. Journal of Reproduction and Fertility 105, 253–257.

    CAS  PubMed  Google Scholar 

  243. Shiono, H., Yagi, Y., Thongnoon, P., Kurabayashi, N., Chikayama, Y., Miyazaki, S., Nakamura, I., 2001. Acquired methemoglobinemia in anemic cattle infected with Theileria sergenti. Veterinary Parasitology 102, 45–51.

    CAS  PubMed  Google Scholar 

  244. Shiono, H., Yagi, Y., Chikayama, Y., Miyazaki, S., Nakamura, I., 2003. The influence of oxidative bursts of phagocytes on red blood cell oxidation in anemic cattle infected with Theileria sergenti. Free Radical Research 37, 1181–1189.

    CAS  PubMed  Google Scholar 

  245. Shiono, H., Yagi, Y., Chikayama, Y., Miyazaki, S., Nakamura, I., 2003. Oxidative damage and phosphatidylserine expression of red blood cells in cattle experimentally infected with Theileria sergenti. Parasitology Research 89, 228–234.

    PubMed  Google Scholar 

  246. Silanikove, N., 2000. Effects of heat stress on the welfare of extensively managed domestic ruminants. Livestock Production Science 67, 1–18.

    Google Scholar 

  247. Slama, H., Vaillancourt, D., Goff, A.K., 1994. Control of in vitro prostaglandin F2[alpha] and E2 synthesis by caruncular and allantochorionic tissues from cows that calved normally and those with retained fetal membranes. Domestic Animal Endocrinology 11, 175–185.

    CAS  PubMed  Google Scholar 

  248. Smith, R., 1978. S-methylcysteine sulphoxide, the brassica anaemia factor (a valuable dietary factor for man?). Veterinary Research Communications 2, 47–61.

    Google Scholar 

  249. Smith, J.A., 1994. Neutrophils, host defense, and inflammation: a double-edged sword. Journal of Leukocyte Biology 56, 672–686.

    CAS  PubMed  Google Scholar 

  250. Smith, R.H., Watt, W.B., Lawson, W.J., Rice-Evans, C., 1982. Red cell membrane changes in a Heinz body anaemia. Protides Biological Fluid 29, 125–128.

    Google Scholar 

  251. Smith, K.L., Harrison, J.H., Hancock, D.D., Todhunter, D.A., Conrad, H.R., 1984. Effect of vitamin E and selenium supplementation on incidence of clinical mastitis and duration of clinical symptoms. Journal of Dairy Science 67, 1293–1300.

    CAS  PubMed  Google Scholar 

  252. Smith, K.L., Hogan, J.S., Weiss, W.P., 1997. Dietary vitamin E and selenium affect mastitis and milk quality. Journal of Animal Science 75, 1659–1665.

    CAS  PubMed  Google Scholar 

  253. Smith, A., Madden, K.B., Yeung, K.J.A., Zhao, A., Elfrey, J., Finkelman, F., Levander, O., Shea-Donohue, T., Urban, J.F., Jr., 2005. Deficiencies in selenium and/or vitamin E lower the resistance of mice to Heligmosomoides polygyrus infections. Journal of Nutrition 135, 830–836.

    CAS  PubMed  Google Scholar 

  254. Sordillo, L.M. and Aitken, S.L., 2009. Impact of oxidative stress on the health and immune function of dairy cattle. Veterinary Immunology and Immunopathology 128(1–3), 104–109.

    CAS  PubMed  Google Scholar 

  255. Soriani, M., Pietraforte, D., Minetti, M., 1994. Antioxidant potential of anaerobic human plasma: role of serum albumin and thiols as scavengers of carbon radicals. Archives of Biochemistry and Biophysics 312, 180–188.

    CAS  PubMed  Google Scholar 

  256. Spears, J.W., 2000. Micronutrients and immune function in cattle. Proceedings of the Nutrition Society 59, 587–594.

    CAS  PubMed  Google Scholar 

  257. Spears, J.W., Weiss, W.P., 2008. Role of antioxidants and trace elements in health and immunity of transition dairy cows. The Veterinary Journal. Production Diseases of the Transition Cow 176, 70–76.

    CAS  Google Scholar 

  258. Staats, D.A., Lohr, D.P., Colby, H.D., 1988. Effects of tocopherol depletion on the regional differences in adrenal microsomal lipid peroxidation and steroid metabolism. Endocrinology 123, 975.

    CAS  PubMed  Google Scholar 

  259. Stabel, J.R., Spears, J.W., Brown Jr., T.T., Brake, J., 1989. Selenium effects on glutathione peroxidase and the immune response of stressed calves challenged with Pasteurella hemolytica. Journal of Animal Science 67, 557–564.

    CAS  PubMed  Google Scholar 

  260. Sugino, N., 2006. Roles of reactive oxygen species in the corpus luteum. Animal Science Journal 77, 556–565.

    CAS  Google Scholar 

  261. Takahashi, M., Keicho, K., Takahashi, H., Ogawa, H., Schulte, R.M., Okano, A., 2000. Effect of oxidative stress on development and DNA damage in in-vitro cultured bovine embryos by comet assay. Theriogenology 54, 137–145.

    CAS  PubMed  Google Scholar 

  262. Tanaka, M., Miyazaki, T., Tanigaki, S., Kasai, K., Minegishi, K., Miyakoshi, K., Ishimoto, H., Yoshimura, Y., 2000. Participation of reactive oxygen species in PGF2alpha-induced apoptosis in rat luteal cells. Journal of Reproduction & Fertility 120, 239–245.

    CAS  Google Scholar 

  263. Torres-Acosta, J.F.J., Hoste, H., 2008. Alternative or improved methods to limit gastro-intestinal parasitism in grazing sheep and goats. Small Ruminant Research. Sheep and Goat Farming: grazing systems of production and development 77, 159–173.

    Google Scholar 

  264. Trout, J.P., McDowell, L.R., Hansen, P.J., 1998. Characteristics of the estrous cycle and antioxidant status of lactating holstein cows exposed to heat stress. Journal of Dairy Science 81, 1244–1250.

    CAS  PubMed  Google Scholar 

  265. Tucker, E.M., Kilgour, L., 1973. The effect of anaemia on sheep with inherited differences in red cell reduced glutathione (GSH) concentrations. Research in Veterinary Science 14, 306–311.

    CAS  PubMed  Google Scholar 

  266. Turk, R., Juretic, D., Geres, D., Turk, N., Rekic, B., Simeon-Rudolf, V., Svetina, A., 2004. Serum paraoxonase activity and lipid parameters in the early postpartum period of dairy cows. Research in Veterinary Science 76, 57–61.

    CAS  PubMed  Google Scholar 

  267. Turrens, J.F., 2004. Oxidative stress and antioxidant defenses: a target for the treatment of diseases caused by parasitic protozoa. Molecular Aspects of Medicine Oxidative Stress in Aging and Disease - Mitochondrial Aging, Neuronal Fuction and Neurodegeneration, and Oxidative Metabolic Disorders and Diseases 25, 211–220.

    CAS  PubMed  Google Scholar 

  268. Tüzün, A., Erdil, A., Inal, V., Aydin, A., Bagci, S., Yesilova, Z., Sayal, A., Karaeren, N., Dagalp, K., 2002. Oxidative stress and antioxidant capacity in patients with inflammatory bowel disease. Clinical Biochemistry 35, 569–572.

    PubMed  Google Scholar 

  269. Ueland, P.M., Mansoor, M.A., Guttormsen, A.B., Muller, F., Aukrust, P., Refsum, H., Svardal, A.M., 1996. Reduced, oxidized and protein-bound forms of homocysteine and other aminothiols in plasma comprise the redox thiol status – a possible element of the extracellular antioxidant defense system. Journal of Nutrition 126, 1281S–1284S.

    CAS  PubMed  Google Scholar 

  270. Upcroft, P., Upcroft, J.A., 2001. Drug targets and mechanisms of resistance in the anaerobic protozoa. Clinical Microbiology Reviews 14, 150–164.

    CAS  PubMed Central  PubMed  Google Scholar 

  271. Urban-Chmiel, R., 2006. The influence of transport stress on oxidative stress parameters in bovine leukocytes. Slovakian Veterinary Research 43, 243–246.

    Google Scholar 

  272. Urban-Chmiel, R., Kankofer, M., Wernicki, A., Albera, E., Puchalski, A., 2009. The influence of different doses of [alpha]-tocopherol and ascorbic acid on selected oxidative stress parameters in in vitro culture of leukocytes isolated from transported calves. Livestock Science 124, 89–92.

    Google Scholar 

  273. Van Houtert, M.F.J., Sykes, A.R., 1996. Implications of nutrition for the ability of ruminants to withstand gastrointestinal nematode infections. International Journal for Parasitology 26, 1151–1167.

    PubMed  Google Scholar 

  274. Vega, M., Castillo, T., Retamales, I., Las Heras, J., Devoto, L., Videla, L.A., 1994. Steroidogenic capacity and oxidative stress-related parameters in human luteal cell regression. Free Radical Biology and Medicine 17, 493–499.

    CAS  PubMed  Google Scholar 

  275. Velasquez-Pereira, J., McDowell, L.R., Risco, C.A., Prichard, D., Martin, F.G., Calhoun, M.C., Williams, S.N., Wilkinson, N.S., Ogebe, P., 1998. Effects on performance, tissue integrity, and metabolism of vitamin E supplementation for beef heifers fed a diet that contains gossypol. Journal of Animal Science 76, 2871–2884.

    CAS  PubMed  Google Scholar 

  276. Velez-Pardo, C., Morales, A.T., Rio, M.J.D., Olivera-Angel, M., 2007. Endogenously generated hydrogen peroxide induces apoptosis via mitochondrial damage independent of NF-[kappa]B and p53 activation in bovine embryos. Theriogenology 67, 1285–1296.

    CAS  PubMed  Google Scholar 

  277. Venditti, P., Meo, S., 2006. Thyroid hormone-induced oxidative stress. Cellular and Molecular Life Sciences (CMLS) 63, 414–434.

    CAS  Google Scholar 

  278. Vincent, H.K., Innes, K.E., Vincent, K.R., 2007. Oxidative stress and potential interventions to reduce oxidative stress in overweight and obesity. Diabetes, Obesity and Metabolism 9, 813–839.

    CAS  PubMed  Google Scholar 

  279. Wang, P.G., Xian, M., Tang, X., Wu, X., Wen, Z., Cai, T., Janczuk, A.J., 2002. Nitric oxide donors: chemical activities and biological applications. Chemical Reviews 102, 1091–1134.

    CAS  PubMed  Google Scholar 

  280. Warriss, P., Brown, S., Knowles, T., Kestin, S., Edwards, J., Dolan, S., Phillips, A., 1995. Effects on cattle of transport by road for up to 15 hours. Veterinary Record 136, 319–323.

    CAS  PubMed  Google Scholar 

  281. Waterman, W.R., John, M.E., Simpson, E.R., 1986. Regulation of synthesis and activity of cytochrome P-450 enzymes in physiological pathways. In: P.R. Ortiz de Montellano (Ed.), Cytochrome P-450: Structure, Mechanism, and Biochemistry, Plenum Press, New York, NY, 345 pp.

    Google Scholar 

  282. Weiss, W.P., Smith, K.L., Hogan, J.S., Steiner, T.E., 1995. Effect of forage to concentrate ratio on disappearance of vitamins A and E during in vitro ruminal fermentation. Journal of Dairy Science 78, 1837–1842.

    CAS  PubMed  Google Scholar 

  283. Weiss, W.P., Hogan, J.S., Todhunter, D.A., Smith, K.L., 1997. Effect of vitamin E supplementation in diets with a low concentration of selenium on mammary gland health of dairy cows. Journal of Dairy Science 80, 1728–1737.

    CAS  PubMed  Google Scholar 

  284. Weiss, W.P., Hogan, J.S., Smith, K.L., 2004. Changes in vitamin C concentrations in plasma and milk from dairy cows after an intramammary infusion of Escherichia coli. Journal of Dairy Science 87, 32–37.

    CAS  PubMed  Google Scholar 

  285. Wernicki, A., Urban-Chmiel, R., Kankofer, M., Mikucki, P., Puchalski, A., Tokarzewski, S., 2006. Evaluation of plasma cortisol and TBARS levels in calves after short-term transportation. Revue de Médicine Vétérinaire 157, 30–34.

    CAS  Google Scholar 

  286. Wessely-Szponder, J., Urban-Chmiel, R., Wernicki, A., Bobowiec, R., 2005. Effect of leukotoxin of M. haemolytica and LPS of E. coli on secretory response of bovine neutrophils in vitro. Polish Journal of Veterinary Science 8, 99–105.

    CAS  Google Scholar 

  287. Whelan, B.R., Barrow, N.J., Peter, D.W., 1994. Selenium fertilizers for pastures grazed by sheep. 2. Wool and liveweight responses to selenium. Australian Journal of Agricultural Research 45, 877–887.

    CAS  Google Scholar 

  288. White, C.L., Rewell, L., 2007. Vitamin E and selenium status of sheep during autumn in Western Australia and its relationship to the incidence of apparent white muscle disease. Australian Journal of Experimental Agriculture 47, 535–543.

    CAS  Google Scholar 

  289. Whittaker, D., 1999. Care of dairy cows during turnout to grass. UKVet 4, 24–28.

    Google Scholar 

  290. Williams, A.J., 1976. Metabolism of cysteine by Merino sheep genetically different in wool production. 4. Rates if entry of cystine in to plasma, measured with a single intravenous infection of L-[34S] cystine, and the subsequent incorporation of 35S into wool fibres. Australian Journal of Biological Sciences 29, 513–524.

    CAS  PubMed  Google Scholar 

  291. Witko-Sarsat, V., Friedlander, M., Khoa, T.N., Capeillere-Blandin, C., Nguyen, A.T., Canteloup, S., Dayer, J.-M., Jungers, P., Drueke, T., Descamps-Latscha, B., 1998. Advanced oxidation protein products as novel mediators of inflammation and monocyte activation in chronic renal failure1, 2. Journal of Immunology 161, 2524–2532.

    CAS  Google Scholar 

  292. Witko-Sarsat, V., Nguyen-Khoa, T., Jungers, P., Drueke, T., Descamps-Latscha, B., 1999. Advanced oxidation protein products as a novel molecular basis of oxidative stress in uraemia. Nephrology Dialysis Transplantation 14, 76–78.

    CAS  Google Scholar 

  293. Woolaston, R.R., Baker, R.L., 1996. Prospects of breeding small ruminants for resistance to internal parasites. International Journal for Parasitology. Novel Approaches to the Control of Helminth Parasites of Livestock 26, 845–855.

    CAS  Google Scholar 

  294. Wu, G., Fang, Y.-Z., Yang, S., Lupton, J.R., Turner, N.D., 2004. Glutathione metabolism and its implications for health. Journal of Nutrition 134, 489–492.

    CAS  PubMed  Google Scholar 

  295. Yagi, K., 1998. Simple assay for the level of total lipid peroxides in serum or plasma. Methods in Molecular Biology (Clifton, N.J.) 108, 101–106.

    CAS  Google Scholar 

  296. Yagi, Y., Thongnoon, P., Shiono, H., Chikayama, Y., 2002. Increase in oxidized proteins in Theileria sergenti-infected erythrocyte membrane. Journal of Veterinary Medical Science 64, 623–625.

    CAS  PubMed  Google Scholar 

  297. Yamashita, T., Someya, A., 1987. Comparative study on the stimulation of superoxide production in guinea-pig eosinophils by the calcium ionophore A23187. Biochimica et Biophysica Acta (BBA) – Molecular Cell Research 927, 359–365.

    CAS  Google Scholar 

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  1. C04 MC Franklin Lab, University of Sydney, PMB 3, 425 Werombi Rd, Camden, NSW, 2570, Australia

    Pietro Celi

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    Lester Mandelker

  2. Faculty of Veterinary Sciences, Department of Internal Medicine and Clin, Szent Istvan University, Istvan u. 2, Budapest, 1143, Hungary

    Peter Vajdovich

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Celi, P. (2011). Oxidative Stress in Ruminants. In: Mandelker, L., Vajdovich, P. (eds) Studies on Veterinary Medicine. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-071-3_13

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