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Slow-Growing Nontuberculous Mycobacteria in Transplant

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Emerging Transplant Infections

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Abstract

Nontuberculous mycobacteria (NTM) are ubiquitous environmental organisms found in soil and water. The expansion of the transplant population combined with an increase in environmental exposures and improvements in mycobacterial diagnosis has contributed to a rise in the diagnosis of NTM infections among transplant recipients, who are at particular risk for infection as well as increased associated morbidity and mortality.

The diagnosis and management of NTM in the transplanted host are challenging. Disease manifestations can be nonspecific, and recognition of invasive infection can be difficult. A combination of culture and molecular diagnostic techniques may be required to make the diagnosis. Treatment of NTM infections is complex due to the need for prolonged therapeutic regimens with multiple drugs with associated toxicities and the need to consider drug-drug interactions between antimicrobials and immunosuppressive agents. We will discuss the epidemiology, clinical presentation, diagnosis, and management of infections in the transplanted host with the most common slow-growing NTM.

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Authors and Affiliations

  1. School of Medicine, Division of Infectious Diseases, University of Colorado, Aurora, CO, USA

    Esther Benamu

  2. Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA

    Joanna Nelson

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  1. Esther Benamu
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Correspondence to Esther Benamu .

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Editors and Affiliations

  1. Miller School of Medicine, University of Miami, Miami, FL, USA

    Michele I. Morris

  2. Massachusetts General Hospital, Harvard University, Boston, MA, USA

    Camille Nelson Kotton

  3. Duke University, Durham, NC, USA

    Cameron Wolfe

Section Editor information

  1. Division of Infectious Diseases, University of Miami Miller School of Medicine, Miami, FL, USA

    Michele I. Morris

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Benamu, E., Nelson, J. (2020). Slow-Growing Nontuberculous Mycobacteria in Transplant. In: Morris, M.I., Kotton, C.N., Wolfe, C. (eds) Emerging Transplant Infections. Springer, Cham. https://doi.org/10.1007/978-3-030-01751-4_17-1

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  • DOI: https://doi.org/10.1007/978-3-030-01751-4_17-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-01751-4

  • Online ISBN: 978-3-030-01751-4

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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