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Nanotheranostics-Based Imaging for Cancer Treatment Monitoring

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Nanotheranostics for Cancer Applications

Part of the book series: Bioanalysis ((BIOANALYSIS,volume 5))

Abstract

The rapidly developing field of cancer treatment requires versatile strategies for controlled drug delivery and diagnostics. Molecular imaging technology has gained attraction in cancer diagnosis and therapy, partially driven by nanoparticle-based theranostic agents. Nanotheranostics-based imaging platforms offer insights into both malignancy diagnosis and therapeutic response monitoring. Monitoring body response to certain cancer treatment will offer suitable pathological and surgical evaluation guides to evaluate how tumors shrink/metastasize, as well as the side effects associated with the therapeutic approach. This chapter summarizes fundamental imaging features of nanotheranostics, specifically, treatment monitoring in cancer therapy, with applications in therapeutic monitoring, such as tracking angiogenesis, metastasis, and apoptosis, following primary treatment. This chapter also offers an outlook for future translation and clinical applications of such multifunctional nanoconstructs.

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Acknowledgments

This work was supported by the College of Engineering and Mathematics, University of Vermont; MOST of China (Grant Nos. 2017YFA0205201, 2014CB744503, and 2013CB733802); the NSFC under Grant Nos. 81422023, 81371596, 51273165, U1705281, and U1505221; the Program for New Century Excellent Talents in University (NCET-13-0502); the Fundamental Research Funds for the Central Universities, China (20720150206 and 20720150141); and the Intramural Research Program, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health.

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Authors and Affiliations

  1. Bioengineering Program, College of Engineering and Mathematical Sciences, College of Medicine, University of Vermont, Burlington, VT, USA

    Tianxin Miao & Rachael A. Floreani

  2. Mechanical Engineering Program, College of Engineering and Mathematical Sciences, University of Vermont, Burlington, VT, USA

    Rachael A. Floreani

  3. State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China

    Gang Liu

  4. Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, USA

    Xiaoyuan Chen

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  1. Tianxin Miao
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  3. Gang Liu
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  4. Xiaoyuan Chen
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Correspondence to Gang Liu or Xiaoyuan Chen .

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Editors and Affiliations

  1. Department of Chemical Engineering, University of Massachusetts Lowell, Lowell, MA, USA

    Prakash Rai

  2. National Cancer Institute, NIH Nanodelivery Systems and Devices Branch Cancer Imaging Program, Division of Cancer Treatment and Diagnosis, Rockville, MD, USA

    Stephanie A. Morris

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Miao, T., Floreani, R.A., Liu, G., Chen, X. (2019). Nanotheranostics-Based Imaging for Cancer Treatment Monitoring. In: Rai, P., Morris, S.A. (eds) Nanotheranostics for Cancer Applications. Bioanalysis, vol 5. Springer, Cham. https://doi.org/10.1007/978-3-030-01775-0_16

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