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Ethnopharmacology and Medicinal Uses of Extreme Halophytes

Handbook of Halophytes

Abstract

Extreme halophytes are a promising source of pharmaceuticals on the base of the secondary metabolites and osmolytes they accumulate. However, under saline stress condition, other undesirable substances such as Na, Cl, and heavy metals are also accumulated, raising a serious concern on the possibilities of use of extreme halophytes as crude drugs.

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References

  • Álvarez Rogel, J., Hernández, J., Ortiz, R., & Alcaraz, F. (1997). Patterns of spatial and temporal variations in soli salinity: Example of a salt marsh in a semiarid climate. Arid Soil Research and Rehabilitation, 11, 315–329. https://doi.org/10.1080/15324989709381485.

    Article  Google Scholar 

  • Álvarez Rogel, J., Ortiz, R., & Alcaraz, F. (2001a). Edaphic characterization and soil ionic composition influencing plant zonation in a semiarid Mediterranean salt marsh. Geoderma, 99, 81–98. https://doi.org/10.1016/s0016-7061(00)00067-7.

    Article  Google Scholar 

  • Álvarez Rogel, J., Ortiz, R., Vela de Oro, N., & Alcaraz, F. (2001b). The application of the FAO and US soil taxonomy systems to saline soils in relation to halophytic vegetation in SE Spain. Catena, 45, 73–84. https://doi.org/10.1016/s0341-8162(01)00141-2.

    Article  Google Scholar 

  • Aronson, J. (1989). HALOPH: Salt tolerant plants for the World – A computerized global data base of halophytes with emphasis on their economic uses. Tucson: University of Arizona Press.

    Google Scholar 

  • Ayush. (2019). Ministry of Ayush. http://ayush.gov.in/. Last accessed 19 Nov 2019.

  • Biondi, E., Casavecchia, S., Estrelles, E., & Soriano, P. (2013). Halocnemum M. Bieb. vegetation in the Mediterranean Basin. Plant Biosystems, 147(3), 536–547. https://doi.org/10.1080/11263504.2013.832709.

    Article  Google Scholar 

  • Bnouham, M., Mekhfi, H., Legssyer, A., & Ziyyat, A. (2002). Medicinal plants used in the treatment of diabetes in Morocco. International Journal of Diabetes & Metabolism (Ethnopharmacology Forum), 10, 33–50.

    Google Scholar 

  • Buhmann, A., & Papenbrock, J. (2013). An economic point of view of secondary compounds in halophytes. Functional Plant Biology, 40(9), 952–967.

    Article  PubMed  Google Scholar 

  • Cho, J. Y., Yang, X., Park, K. H., Park, H. J., Park, S. Y., Moon, J. H., & Ham, K. S. (2013). Isolation and identification of antioxidative compounds and their activities from Suaeda japonica. Food Science and Biotechnology, 22(6), 1547–1557.

    Article  CAS  Google Scholar 

  • De la Fuente, V., Rufo, L., & Sánchez-Mata, D. (2011). Sarcocornia hispanica (Chenopodiaceae), a new species from the Iberian Peninsula. Lazaroa, 32, 9–13. https://doi.org/10.5209/rev_LAZA.2011.v32.37817.

    Article  Google Scholar 

  • De la Fuente, V., Rufo, L., Rodríguez, N., Sánchez-Mata, D., Franco, A., & Amilsc, R. (2015). A study of Sarcocornia A.J. Scott (Chenopodiaceae) from Western Mediterranean Europe. Plant Biosystems, 150(2), 343–356. https://doi.org/10.1080/11263504.2015.1022239.

    Article  Google Scholar 

  • Dudai, N., Raz, A., Hofesh, N., Rozenzweig, N., Aharon, R., Fischer, R., Chaimovitsh, D., & Segev, D. (2008). Antioxidant activity and phenol content of plant germplasm originating in the Dead Sea area. Israel Journal of Plant Sciences, 56/3, 227–232.

    Article  Google Scholar 

  • eHALOPH. (2019). Halophytes database. https://www.sussex.ac.uk/affiliates/halophytes/index.php. Last accessed 19 Nov 2019.

  • EMA. (2019). European Union monographs and list entries. https://www.ema.europa.eu/en/human-regulatory/herbal-products/european-union-monographs-list-entries. Last accessed 19 Nov 2019.

  • English, J. P., & Colmer, T. D. (2013). Tolerance of extreme salinity in two stem-succulent halophytes (Tecticornia species). Functional Plant Biology, 40(9), 897–912.

    Article  CAS  PubMed  Google Scholar 

  • Ernianingsih, S. W., & Mukarlina, R. L. (2014). Etnofarmakologi Tumbuhan Mangrove Achantus ilicifolius L., Acrostichum speciosum L. dan Xylocarpus rumphiiMabb. Di Desa Sungai Tekong Kecamatan Sungai Kakap Kabupaten Kubu Raya. Protobiont, 3(2), 252–258.

    Google Scholar 

  • EUNIS. (2019). European Nature Information System. https://eunis.eea.europa.eu/index.jsp. Last accessed 19 Nov 2019.

  • FDA. (2019). Dietary Supplement Products & Ingredients. https://www.fda.gov/food/dietary-supplements/dietary-supplement-products-ingredients. Last accessed 19 Nov 2019.

  • Gao, H., Hong, K., Chen, G., Wang, C., Tang, J., Yu, Y., Jiang, M., Li, M., Wang, N., & Yao, X. (2010). New oxidized sterols from Aspergillus awamori and the endo boat conformation adopted by the cyclohexene oxide system. Magnetic Resonance in Chemistry, 48(1), 38–43.

    Article  CAS  PubMed  Google Scholar 

  • Gargouri, M., Hamed, H., Akrouti, A., Christian, M., Ksouri, R., & El Feki, A. (2017). Immunomodulatory and antioxidant protective effect of Sarcocornia perennis L. (swampfire) in lead intoxicated rat. Toxicology Mechanisms and Methods, 27(9), 697–706.

    Article  CAS  PubMed  Google Scholar 

  • GBIF. (2019). GBIF | Global Biodiversity Information Facility, free and open access to biodiversity data. https://www.gbif.org/. Last accessed 19 Nov 2019.

  • Ghabriche, R., Ghnava, T., Mnasri, M., Zaier, H., Baioui, R., Vromman, D., Abdelly, C., & Lutts, S. (2017). Polyamine and tyramine involvement in NaCl-induced improvement of Cd resistance in the halophyte Inula crithmoides L. J. Plant Physiology, 216, 136–144.

    Article  CAS  Google Scholar 

  • Ghazanfar, S. A., Altundag, E., Yaprak, A. E., Osborne, J., Tug, G. N., & Vural, M. (2014). Halophytes of Southwest Asia. In M. A. Khan et al. (Eds.), Sabkha Ecosystems: Volume IV: Cash Crop Halophyte and Biodiversity Conservation (Tasks for Vegetation Science 47) (pp. 105–133). Dordrecht: Springer.

    Chapter  Google Scholar 

  • Gómez-Mercado, F., Del Moral, F., Giménez, E., & De Haro, S. (2012). Salinity tolerance of the hygrophilous plant species in the wetlands of the south of the Iberian Peninsula. Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 40(1), 18–28.

    Article  Google Scholar 

  • Grigore, M. N., & Toma, C. (2010). A proposal for a new halophytes classification based on integrative anatomy observations. Muz. Olteniei, Craiova, Stud. şi Com., Şt. Nat, 26(1), 45–50.

    Google Scholar 

  • Grigore, M. N., Boscaiu-Neagu, M. T., & Vicente, Ó. (2011). Assessment of the relevance of osmolyte biosynthesis for salt tolerance of halophytes under natural conditions. European Journal of Plant Science and Biotechnology, 5(Special issue 2), 12–19.

    Google Scholar 

  • Guerreiro, C. (2018). Chemical and Biological characterization of halophyte plants with ethnopharmacological use in the Algarve coast. PhD. Universidade do Algarve.

    Google Scholar 

  • Halberstein, R. A. (2005). Medicinal plants: Historical and cross-cultural usage patterns. Annals of Epidemiology, 15(9), 686–699.

    Article  PubMed  Google Scholar 

  • Hayakawa, K., Toe, S., & Akihiro, N. (2008). Physiological effects of betacyanin on photosynthesis rate, chlorophyll fluorescence and resistance to oxidative stress in turkeys (Suaeda japonica Makino). Tropical Agriculture Studies, 1(2), 55–63.

    CAS  Google Scholar 

  • Hussin, N. M., Muse, R., Ahmad, S., Ramli, J., Mahmood, M., Sulaiman, M., Shukor, M., Rahman, M., & Aziz, K. (2009). Antifungal activity of extracts and phenolic compounds from Barringtonia racemosa L. (Lecythidaceae). African Journal of Biotechnology, 8(12), 2835–2842. Available online at http://www.academicjournals.org/AJB.

    CAS  Google Scholar 

  • IPNI. (2019). International Plant Names Index (IPNI). https://www.ipni.org. Last accessed 20 Nov 2019.

  • Kadereit, G., & Freitag, H. (2011). Molecular phylogeny of Camphorosmeae (Camphorosmoideae, Chenopodiaceae): Implications for biogeography, evolution of C4-photosynthesis and taxonomy. Taxon, 60(1), 51–78.

    Article  Google Scholar 

  • Kang, H., Koppula, S., Kim, H. K., & Park, T. K. (2013). Suaeda japonica Makino attenuates lipopolysaccharide-induced neuro-inflammatory responses in BV-2 microglia via NF-kappa B signaling. Tropical Journal of Pharmaceutical Research, 12(3), 351–356.

    Google Scholar 

  • Kannan, R., Arumugam, R., & Anantharaman, P. (2012). Chemical composition and antibacterial activity of Indian seagrasses against urinary tract pathogens. Food Chemistry, 135(4), 2470–2473.

    Article  CAS  Google Scholar 

  • Kannan, R., Arumugam, R., & Anantharaman, P. (2013). Pharmaceutical potential of a fucoidan-like sulphated polysaccharide isolated from Halodule pinifolia. International Journal of Biological Macromolecules, 62, 30–34.

    Article  CAS  PubMed  Google Scholar 

  • Kargar, H., Khajeddin, S. J., & Karimzadeh, H. R. (2012). Soil-vegetation relationships of three arid land plant species and their use in rehabilitating degraded sites. Land Degradation and Development, 23, 92–101. https://doi.org/10.1002/ldr.1057.

    Article  Google Scholar 

  • Kefu, Z., Zi-Yi, C., Shou-Jin, F., Giang, H. X., Hai, F., Zeng, L. F., & Harris, P. J. C. (1995). Halophytes in China. In Biology of salt tolerant plants (pp. 284–293). Karachi: Department of Botany, University of Karachi.

    Google Scholar 

  • Kim, D., Sohn, H., & Kweon, M. (2017). Pharmaceutical composition comprising Salicornia spp. as an active ingredient for the prevention or treatment of thrombosis, and health functional food comprising the same. World Intellectual Property Organization. WO 2017/043914 A3.

    Google Scholar 

  • Kshirsagar, A. D., Mohite, R., Aggrawal, A. S., & Suralkar, U. R. (2011). Hepatoprotective medicinal plants of Ayurveda-A review. Asian Journal of Pharmaceutical and Clinical Research, 4(3), 1–8.

    Google Scholar 

  • Ksouri, R., Ksouri, W. M., Jallali, I., Debez, A., Magné, C., Hiroko, I., & Abdelly, C. (2012). Medicinal halophytes: Potent source of health promoting biomolecules with medical, nutraceutical and food applications. Critical Reviews in Biotechnology, 32(4), 289–326.

    Article  CAS  PubMed  Google Scholar 

  • Lagasca, M. (1817). Memoria sobre las plantas barrilleras de España. Madrid: Imprenta Real.

    Google Scholar 

  • Lakhdari, W., Dehliz, A., Acheuk, F., Mlik, R., Hammi, H., Doumandji, B., Gheriani, S., Berrekbia, M., Guermit, K., & Chergui, S. (2016). Ethnobotanical study of some plants used in traditional medicine in the region of Oued Righ (Algerian Sahara). Journal of Medicinal Plants Studies, 4(2), 204–211.

    Google Scholar 

  • Lanfranco, G. (1960). Cynomorium coccineum Linn. A Maltese historical plant. Journal of the Malta Historical Society, 3, 53–70.

    Google Scholar 

  • Leonti, M., Bellot, S., Zucca, P., & Rescigno, A. (2019). Astringent drugs for bleedings and diarrhoea: The history of Cynomorium coccineum (Maltese Mushroom). Journal of Ethnopharmacology. https://doi.org/10.1016/j.jep.2019.112368.

  • Lopes, A., Rodrigues, M. J., Pereira, C., Oliveira, M., Barreira, L., Varela, J., Trampetti, F., & Custódio, L. (2016). Natural products from extreme marine environments: Searching for potential industrial uses within extremophile plants. Industrial Crops and Products, 94, 299–307.

    Article  CAS  Google Scholar 

  • Medini, F., Fellah, H., Ksouri, R., & Abdelly, C. (2014). Total phenolic, flavonoid and tannin contents and antioxidant and antimicrobial activities of organic extracts of shoots of the plant Limonium delicatulum. Journal of Taibah University for Science, 8(3), 216–224. https://doi.org/10.1016/j.jtusci.2014.01.003.

    Article  Google Scholar 

  • Mohammed, R., El-Hawary, S. S., & Abo-youssef, A. M. (2012). Biological investigation of some wild Aizoaceae and Chenopediaceae species growing in Egypt. Journal of Natural Products, 5, 193–206.

    Google Scholar 

  • Nabeel, M., Kathiresan, K., & Manivannan, S. (2010). Antidiabetic activity of the mangrove species Ceriops decandra in alloxan-induced diabetic rats. Journal of Diabetes, 2(2), 97–103.

    Article  PubMed  Google Scholar 

  • Ortiz, R., Álvarez Rogel, J., & Alcaraz, F. (1995). Soil-vegetation relationships in two coastal salt marshes in Southeastern Spain. Arid Soil Research and Rehabilitation, 9, 481–493. https://doi.org/10.1080/15324989509385914.

    Article  Google Scholar 

  • Osbaldeston, T. (2000). Dioscorides de Materia Medica. Johannesburg: Ibidis Press.

    Google Scholar 

  • Oudhia, P. (2007). Caesalpinia bonduc (L.) Roxb. [Internet] Record from PROTA4U. In G. H. Schmelzer & A. Gurib-Fakim (Eds.), PROTA (Plant Resources of Tropical Africa/Ressources végétales de l’Afrique tropicale). Netherlands: Wageningen. http://www.prota4u.org/search.asp. Accessed 12 Dec 2019.

    Google Scholar 

  • Ozgur, R., Uzilday, B., Sekmen, A. H., & Turkan, I. (2013). Reactive oxygen species regulation and antioxidant defence in halophytes. Functional Plant Biology, 40(9), 832–847.

    Article  CAS  PubMed  Google Scholar 

  • Öztürk, M., Altay, V., Gucel, S., & Guvensen, A. (2014). Halophytes in the East Mediterranean–their medicinal and other economical values. In M. A. Khan, B. Böer, M. Öztürk, T. Z. Al Abdessalaam, M. Clüsener-Godt, & B. Gul (Eds.), Sabkha ecosystems. Tasks for vegetation science (Vol. 47, pp. 247–272). Dordrecht: Springer.

    Google Scholar 

  • Patel, S. (2016). Salicornia: Evaluating the halophytic extremophile as a food and a pharmaceutical candidate. 3 Biotech, 6(1), 104. https://doi.org/10.1007/s13205-016-0418-6.

    Article  PubMed  PubMed Central  Google Scholar 

  • Patra, J., Dhalb, N., & Thatoic, H. (2011). In vitro bioactivity and phytochemical screening of Suaeda maritima (Dumort): A mangrove associate from Bhitarkanika, India. Asian Pacific Journal of Tropical Medicine, 4(9), 727–734.

    Article  CAS  PubMed  Google Scholar 

  • Priyashree, S., Jha, S., & Pattanayak, S. P. (2010). A review on Cressa cretica Linn.: A halophytic plant. Pharmacognosy Reviews, 4(8), 161–166.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pubchem. (2019). Pubchem, Explore chemistry. https://pubchem.ncbi.nlim.nih.gov/. Last accessed 20 Nov 2019.

  • Qasim, M., Gulzar, S., & Khan, M. A. (2011). Halophytes as medicinal plants. In M. Ozturk, A. R. Mermut, & A. Celik (Eds.), Urbanisation, Land Use, Land Degradation and Environment (pp. 330–342). Delhi: Daya Publishing House.

    Google Scholar 

  • Qasim, M., Abideen, Z., Adnan, M. Y., Ansari, R., Gul, B., & Khan, M. A. (2014). Traditional ethnobotanical uses of medicinal plants from coastal areas. Journal of Coastal Life Medicine, 2(1), 22–30.

    Google Scholar 

  • Qasim, M., Abideen, Z., Adnan, M. Y., Gulzar, S., Gul, B., Rasheed, M., & Khan, M. A. (2017). Antioxidant properties, phenolic composition, bioactive compounds and nutritive value of medicinal halophytes commonly used as herbal teas. South African Journal of Botany, 110, 240–250.

    Article  CAS  Google Scholar 

  • Radwan, H., Nazif, N., & Abou-Setta, L. (2007). Phytochemical investigation of salicornia fruticosa (L.) and their biological activity. Research Journal of Medicine and Medical Sciences, 2(2), 72–78.

    CAS  Google Scholar 

  • Rahman, M., Kim, M., Kim, J., Kim, S., Go, H., Kweon, M., & Kim, D. (2018). Desalted Salicornia europaea powder and its active constituent, trans-ferulic acid, exert anti-obesity effects by suppressing adipogenic-related factors. Pharmaceutical Biology, 56(1), 183–191.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ramírez, E., Rufo, L., Sánchez-Mata, D., & Fuente, V. (2019). Arthrocaulon meridionalis (Chenopodiaceae), a new species of Mediterranean flora. Mediterranean Botany, 40(1), 33–41.

    Article  Google Scholar 

  • Rashid, S., Iftekhar, Q., Arshad, M., & Iqbal, J. (2000). Chemical composition and anti-bacterial activity of Suaeda fruticosa Forsk. from Cholistan, Pakistan. Pakistan Journal of Biological Sciences, 3, 348–349.

    Article  Google Scholar 

  • Resinger, H., & Gómez Gutiérrez, J. M. (1992). Elsevier’s dictionary of terrestrial plant ecology. Amsterdam: Elsevier.

    Google Scholar 

  • Rivera, D., Matilla G., Obón, C., & Alcaraz, F. (2012). Plants and humans in the Near East and the Caucasus. Ancient and traditional uses of plants as food and medicine. An ethnobotanical diachronic review, 2 vols. (1: The landscapes. The plants: Ferns and gymnosperms; 2: The plants: Angiosperms). Murcia. Editum.

    Google Scholar 

  • Rivera, D., Verde, A., Fajardo, J., Obón, C., Consuegra, V., García-Botía, J., Ríos, S., Alcaraz, F., Valdés, A., del Moral, A., & Laguna, E. (2019). Ethnopharmacology in the Upper Guadiana River area (Castile-La Mancha, Spain). Journal of Ethnopharmacology, 241, 111968. https://doi.org/10.1016/j.jep.2019.111968.

    Article  PubMed  Google Scholar 

  • Romojaro, A., Botella, M., Obón, C., & Pretel, T. (2013). Nutritional and antioxidant properties of wild edible plants and their use as potential ingredients in the modern diet. International Journal of Food Sciences and Nutrition, 64(8), 944–952.

    Article  CAS  PubMed  Google Scholar 

  • Salmon, W. (1685). Pharmacopoeia londinensis; or, the New London Dispensatory. In Six books. London: Thomas Dowks.

    Google Scholar 

  • Suryawanshi, H., & Patel, M. (2011). Traditional uses, medicinal and phytopharmacological properties of Caesalpinia crista Linn – An overview. International Journal of Research in Pharmacy and Chemistry, 1(4), 1179–1183.

    Google Scholar 

  • Thatoi, H., Samantaray, D., & Das, S. K. (2016). The genus Avicennia, a pioneer group of dominant mangrove plant species with potential medicinal values: A review. Frontiers in Life Science, 9(4), 267–291.

    Article  CAS  Google Scholar 

  • Ventura, Y., & Sagi, M. (2013). Halophyte crop cultivation: The case for Salicornia and Sarcocornia. Environmental and Experimental Botany, 92, 144–153.

    Article  Google Scholar 

  • Volkmar, K. M., Hu, Y., & Steppuhn, H. (1998). Physiological responses of plants to salinity: A review. Canadian Journal of Plant Science, 78(1), 19–27.

    Article  CAS  Google Scholar 

  • Warming, E. (1909). Oecology of plants. An introduction to the study of plant communities. Oxford: Oxford University Press.

    Book  Google Scholar 

  • WFO. (2019). World Flora Online. Published on the Internet; http://www.worldfloraonline.org. Last accessed 16 Oct 2019.

  • WHO. (2019). Essential medicines and health products information portal. https://apps.who.int/medicinedocs/en/d/Js2200e/. Last accessed 20 Nov 2019.

  • Zengin, G., Aumeeruddyi, Z., Mollica, A., Yilmaz, M. A., & Mahomoodally, M. F. (2018). In vitro and in silico perspectives on biological and phytochemical profile of three halophyte species – A source of innovative phytopharmaceuticals from nature. Phytomedicine, 38, 35–44.

    Article  CAS  PubMed  Google Scholar 

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Obón, C., Rivera, D., Verde, A., Alcaraz, F. (2020). Ethnopharmacology and Medicinal Uses of Extreme Halophytes. In: Grigore, MN. (eds) Handbook of Halophytes. Springer, Cham. https://doi.org/10.1007/978-3-030-17854-3_107-1

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  1. Latest

    Ethnopharmacology and Medicinal Uses of Extreme Halophytes
    Published:
    03 December 2020

    DOI: https://doi.org/10.1007/978-3-030-17854-3_107-2

  2. Original

    Ethnopharmacology and Medicinal Uses of Extreme Halophytes
    Published:
    09 October 2020

    DOI: https://doi.org/10.1007/978-3-030-17854-3_107-1