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MHC Class-I Loss and Cancer Immune Escape pp 1–14Cite as

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1151))

Abstract

This chapter focuses on the discovery of the Major Histocompatibility Complex (MHC) in mice (H-2) and in humans (HLA), and on the role played by the International HLA Workshops in the analysis and characterization of this complex genetic system. The early days of Tumour Immunology and the importance of the definition of Tumour Associated Transplantation Antigens (TATA) are also discussed. Today we know that tumour cells can be killed by T lymphocytes by recognizing tumour antigenic peptides presented by MHC molecules and they can also escape this recognition by losing the expression of MHC molecules. This important phenomenon has been profoundly studied for many years both in my lab in Granada and in other laboratories. The results of this research have important implications for the new generation of cancer immunotherapy that boosts T cell responses. A historical perspective of major discoveries is presented in this chapter, with the names of the scientists that have made a significant contribution to the enormous progress made in the field of Tumour Immunology.

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  1. Departamento de Analisis Clinicos e Inmunologia, Hospital Universitario Virgen de las Nieves, Facultad de Medicina, Universidad de Granada, Granada, Spain

    Federico Garrido

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  1. Federico Garrido
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Garrido, F. (2019). Introduction. In: MHC Class-I Loss and Cancer Immune Escape. Advances in Experimental Medicine and Biology, vol 1151. Springer, Cham. https://doi.org/10.1007/978-3-030-17864-2_1

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