Skip to main content
SpringerLink
Log in

HLA Class-II Expression in Human Tumors

  • Chapter
  • First Online:
Book cover MHC Class-I Loss and Cancer Immune Escape

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1151))

Abstract

HLA class II molecules play a pivotal role in antigen presentation to T lymphocytes. This chapter analyzed the expression of these molecules in different human tumors and their role in cancer progression. The possible connection between tumor HLA class II expression and the pathogenesis of autoimmune diseases is discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Andersen SN, Rognum TO, Lund E, Meling GI, Hauge S (1993) Strong HLA-DR expression in large bowel carcinomas is associated with good prognosis. Br J Cancer 68:80–85

    Article  CAS  Google Scholar 

  • Botazzo F, Dean BM, McNally JM, MacKay EH, Swift PG, Gamble DR (1985) In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetes insulitis. N Engl J Med 313(6):353–360

    Article  Google Scholar 

  • Brocker EB, Suter L, Bruggen J, Ruiter DJ, Macher E, Sorg C (1985) Phenotypic dinamics of tumour progression in human malignant melanoma. Int J Cancer 36:29–35

    Article  CAS  Google Scholar 

  • Brunner CA, Gokel JM, Riethmuller G, Johnson JP (1991) Expression of HLA-D subloci DR and DQ by breast carcinomas is correlated with distinct parameters of favourable prognosis. Eur J Cancer 27:411–416

    Article  CAS  Google Scholar 

  • Cabrera T, Garrido V, Concha A, Martin J, Esquivias J, Oliva MR, Ruiz-Cabello F, Serrano S, Garrido F (1992) HLA molecules in basal cell carcinoma of the skin. Immunobiology 185:440–452

    Article  CAS  Google Scholar 

  • Cabrera T, Ruiz-Cabello F, Garrido F (1995) Biological implications of HLA-DR expression in tumours. Scand J Immunol 41:398–406

    Article  CAS  Google Scholar 

  • Chen P, Ullrich S, Ananthaswamy H (1994) Presentation of endogenous tumor antigens to CD4+ T lymphocytes by murine melanoma cells transfected with major histocompatibility complex class II genes. J Leukocyte Biol 56:469–474

    Article  CAS  Google Scholar 

  • Concha A, Esteban F, Cabrera T, Ruiz-Cabello F, Garrido F (1991) Tumor aggressiveness and MHC class I and II antigens in laryngeal and breast cancer. Semin Cancer Biol 2:47–54

    CAS  PubMed  Google Scholar 

  • Concha A, Ruiz-Cabello F, Cabrera T, Nogales F, Collado A, Garrido F (1995) Different patterns of HLA-DR antigen expression in normal epithelium, hyperplastic and neoplastic malignant lesions of the breast. Eur J Immunogenet 22:299–310

    Article  CAS  Google Scholar 

  • D’Alessandro G, Zardawi I, Grace J, McCarthy WH, Hersey P (1987) Immunohistological evaluation of MHC class I and II antigen expression on nevi and melanoma: relation to biology of melanoma. Pathology 19:339–346

    Article  Google Scholar 

  • Daar AS, Fuggle SV, Ting A, Fabre JW (1982) Anomalous expression of HLA DR antigens on human colorectal cancer cells. J Immunol 129:447

    CAS  PubMed  Google Scholar 

  • Daar AS, Fuggle SV, Fabre JW, Ting A, Morris P (1984) The detail distribution of MHC class II antigens in normal human organs. Transplantation 38:293–298

    Article  CAS  Google Scholar 

  • Degener T, Momburg F, Moller P (1998) Differential expression of HLA-DR, HLA-DP, HLA-DQ and associated invariant chain (II) in normal colorectal mucosa, adenoma and carcinoma. Virchows Arch A 412:315–322

    Article  Google Scholar 

  • Esteban F, Ruiz-Cabello F, Concha A, Perez-Ayala M, Sanchez-Rozas JA, Garrido F (1990) HLA-DR expression is associated with excellent prognosis in squamous cell carcinoma of the larynx. Clin Exp Metastasis 8:319–328

    Article  CAS  Google Scholar 

  • Ferron A, Perez-Ayala M, Concha A, Cabrera T, Redondo M, Oliva MR, Ruiz-Cabello F, Garrido F (1989) MHC class I and II antigens on gastric carcinomas and autologous mucosa. J Immunogenet 16:413–423

    Article  CAS  Google Scholar 

  • Garrido F, Cabrera T, Concha A, Glew S, Ruiz-Cabello F, Stern PL (1993) Natural history of HLA expression during tumour development. Immunol Today 14:491–499

    Article  CAS  Google Scholar 

  • Ghosh AK, Moore M, Street AJ, Howat JMT, Schofield PF (1986) Expression of HLA-D subregion products on human colorectal carcinoma. Int J Cancer 38:459–464

    Article  CAS  Google Scholar 

  • Glew SS, Duggan-Keen M, Cabrera T, Stern P (1992) HLA class II antigen expression in human papillomavirus associated cervical cancer. Cancer Res 52:1–8

    Google Scholar 

  • Gutierrez J, Lopez-Nevot MA, Cabrera T, Oliva R, Esquivias J, Ruiz-Cabello F, Garrido F (1987) Class I ans II HLA antigen distribution in normal mucosa, adenoma and colon carcinoma: relation with malignancy and invasiveness. Exp Clin Immunogenet 4:144–152

    CAS  PubMed  Google Scholar 

  • Gutierrez J, Ruiz-Cabello F, Lopez-Nevot MA, Cabrera T, Esquivias J, Garrido F (1990) Class II HLA antigen expression in familial polyposis coli is related to the degree of dysplasia. Immunobiology 180:138–148

    Article  CAS  Google Scholar 

  • Hasegawa SL, James LR, Sloan JH, Boos JM (1993) Protease treatment of nuclear extracts distinguishes between class II major histocompatibility complex X1 box DNA-binding proteins in wild type and class II deficient B cells. J Immunol 150:1781–1793

    CAS  PubMed  Google Scholar 

  • Jansson R, Karlsson A, Forsum U (1984) Intrathyroidal HLA-DR expression and T lymphocyte phenotypes in Graves’s thyrotoxicosis, Hasimoto’s thyroiditis and nodular colloid goitre. Clin Exp Immunol 58:264–272

    CAS  PubMed  PubMed Central  Google Scholar 

  • Lopez-Nevot MA, Garcia E, Pareja E, Bonal E, Martin F, Ruiz-Cabello F, Serrano S, Garrido F (1986) Differential expression of HLA class I and II antigens in primary and metastatic melanomas. J Immunogenet 13(2/3):219–228

    Article  CAS  Google Scholar 

  • Lopez-Nevot MA, Garcia E, Romero C, Oliva MR, Serrano S, Garrido F (1988) Phenotypic and genetic analysis of HLA class I and HLA-DR antigen expression on human melanomas. Exp Clin Immunogenet 5:203–212

    CAS  PubMed  Google Scholar 

  • Lundin K, Sollid L (2014) Advances in celiac disease. Curr Opin Gastroenterol 30(2):154–162

    Article  CAS  Google Scholar 

  • Michel S, Linnebacher M, Alcañiz J, Voss M, Wagner R, Dippold W, Becker C, von Knebel Doeberitz M, Ferrone M, Kloor M (2010) Lack of HLA class II antigen expression in microsatellite unstable colorectal carcinomas is caused by mutations in HLA class II regulatory genes. Int J Cancer 127(4):889–898

    CAS  PubMed  PubMed Central  Google Scholar 

  • Momburg F, Herrmann B, Moldehauer G, Moller PB (1987) B cell lymphomas of high-grade malignancy frequently lack HLA-DR, DP and DQ antigens and associated invariant chain. Int J Cancer 40:598–603

    Article  CAS  Google Scholar 

  • Moore M, Ghosh D, Johnston D, Street J (1986) Expression of MHC class II products on human colorectal cancer: an immunohistological and flow cytometric study. J Immunogenet 13:201–209

    Article  CAS  Google Scholar 

  • Natali PG, De Martino C, Quaranta V, Nicotra MR, Frezza F, Pellegrino MA, Ferrone S (1981) Expression of Ia like antigens in normal human non-lymphoid tissues. Transplantation 31:75–78

    Article  CAS  Google Scholar 

  • Natali PG, Giacomini P, Bigotti A, Imai K, Nicotra MR, Ferrone S (1983) Heterogeneity in the expression of HLA and tumor associated antigens by surgically removed and cultured breast carcinoma cells. Cancer Res 43:660–668

    CAS  PubMed  Google Scholar 

  • Ostrand-Rosenberg S (2005) CD4+ T lymphocytes: a critical component of antitumor immunity. Cancer Invest 23:413–419

    CAS  PubMed  Google Scholar 

  • Ostrand-Rosenberg S, Thakur A, Clements V (1990) Rejection of mouse sarcoma cells after transfection of MHC-class II genes. J Immunol 144:4068–4071

    CAS  PubMed  Google Scholar 

  • Pawelec G, Marsh SG (2006) ESTDAB: a collection of immunologically characterized melanoma cell lines and searchable databank. Cancer Immunol Immunother 55:623–627

    Article  CAS  Google Scholar 

  • Perea F, Sánchez-Palencia A, Gómez-Morales M, Bernal M, Concha Á, García MM, González-Ramírez AR, Kerick M, Martin J, Garrido F, Ruiz-Cabello F, Aptsiauri N (2018) HLA class I loss and PD-L1 expression in lung cancer: impact on T-cell infiltration and immune escape. Oncotarget 9(3):4120–4133. https://doi.org/10.18632/oncotarget.23469. eCollection 2018 Jan 9. PubMed PMID: 29423109; PubMed Central PMCID: PMC5790526

  • Redondo M, Concha A, Oldiviela R, Cueto A, Gonzalez A, Garrido F, Ruiz-Cabello (1991) Expression of HLA class I and II antigens in bronchogenic carcinomas: its relationship to cellular DNA content and clinic-pathological parameters. Cancer Res 51:4948–4954

    CAS  PubMed  Google Scholar 

  • Rodriguez T, Mendez R, De Campo A, Aptsiauri N, Martin J, Orozco G, Pawelec G, Shadendorf D, Ruiz-Cabello F, Garrido F (2007) Patterns of constitutive and IFN-γ inducible expression of HLA class II molecules in human melanoma cell lines. Immunogenetics 59:123–133

    Article  CAS  Google Scholar 

  • Ruiter DJ, Bhan AK, Harrist TJ, Sober AJ, Mihm MC (1982) Major histocompatibility antigens and mononuclear inflammatory infiltrate in benign nevomelanocytic proliferations and malignant melanoma. J Immunol 129:2808–2815

    CAS  PubMed  Google Scholar 

  • Ruiter DJ, Bergman W, Welvaart K, Scheffer E, van Vloten WA, Russo C, Ferrone S (1984) Immunohistochemical analysis of malignant melanomas and nevocellular nevi with monoclonal antibodies to distinct monomorphic determinants of HLA antigens. Cancer Res 44:3930–3935

    CAS  PubMed  Google Scholar 

  • Sarna VK, Lundin KEA, Morkrid L, Qiao SW, Sollid LM, Christophersen A (2018) HLA-DQ-Gluten Tetramer blood test accurately identifies patients with and without celiac disease in absence of gluten consumption. Gastroenterology 154(4):886–896

    Article  Google Scholar 

  • Spier CM, Grogan TM, Lippman SM, Slymen DJ, Rybski JA, Miller TP (1988) The aberrancy of immunophenotype and immunoglobuline status as indicators of prognosis in B-cell difuse large-cell lymphoma. Am J Pathol 133:118–126

    CAS  PubMed  PubMed Central  Google Scholar 

  • Stamnaes I, Sollid LM (2015) Celiac disease: autoimmunity in response to food antigen. Semin Immunol 27(5):343–352

    Article  CAS  Google Scholar 

  • Stimac E, Urieli-Shoval S, Kempin S, Pious D (1991) Defective HLA- DRA X box binding in the class II trans activator transcription factor mutant 6.1.6 and in cell lines from class II immunedeficient patients. J Immunol 146:4398–4405

    CAS  PubMed  Google Scholar 

  • Taramelli D, Fosati G, Mazzochi A, Delia D, Ferrone S, Parmiani G (1986) Class I and II HLA and melanoma associated antigen expression and modulation on melanoma cells isolated from primary and metastatic lesions. Cancer Res 46:433–439

    CAS  PubMed  Google Scholar 

  • Van Duinen SG, Mauw BJ, de Graaff-Reitsma CB, Ruiter DJ (1984) Methods in laboratory investigation: Immunoelectron microscopic methods for demonstration of antigens on normal human melanocytes and other epidermal cells. Lab Invest 50:733–741

    PubMed  Google Scholar 

  • Wang E, Worschech A, Marincola FM (2008) The immunological constant of rejection. Trends Immunol 29:256–262

    Article  Google Scholar 

  • Wilson BS, Indiveri F, Pellegrino MA, Ferrone S (1979) DR (Ia-like) antigens on human melanoma cells. Serological detection and immunohistochemical characterization. J Exp Med 149:658–668

    Article  CAS  Google Scholar 

  • Zaloudik J, Moore M, Ghosh AK, Mechl Z, Rejthar A (1988) DNA content and MHC class II antigen expression in malignant melanoma: clinical course. J Clin Pathol 41:1078–1084

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departamento de Analisis Clinicos e Inmunologia, Hospital Universitario Virgen de las Nieves, Facultad de Medicina, Universidad de Granada, Granada, Spain

    Federico Garrido

Authors
  1. Federico Garrido
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Garrido, F. (2019). HLA Class-II Expression in Human Tumors. In: MHC Class-I Loss and Cancer Immune Escape. Advances in Experimental Medicine and Biology, vol 1151. Springer, Cham. https://doi.org/10.1007/978-3-030-17864-2_4

Download citation

Publish with us

Policies and ethics

Search

Navigation