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Surgical Strategies for Neuroblastoma with Spinal Canal Involvement

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Neuroblastoma

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Abstract

Neuroblastoma with spinal canal involvement represents about 5% and 15% of children affected by neuroblastic tumours.

Despite the last years, chemotherapy represents the treatment of choice at diagnosis, also in case of neurologic symptoms and signs, the surgical treatment remains a fundamental instrument for the management of Neuroblastoma with spinal canal involvement.

Surgical strategies will be discussed taking into account the pediatric neurosurgeons’ and visceral surgeons’ points of view.

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References

  1. Hayes FA, Thompson EI, Hvizdala E, O’Connor D, Green AA. Chemotherapy as an alternative to laminectomy and radiation in the management of epidural tumor. J Pediatr. 1984;104(2):221–4.

    Article  CAS  Google Scholar 

  2. Kraal K, Blom T, van Noesel M, Kremer L, Caron H, Tytgat G, van der Pal H. Treatment and outcome of neuroblastoma with intraspinal extension: a systematic review. Pediatr Blood Cancer. 2017;64(8) https://doi.org/10.1002/pbc.26451.

    Article  Google Scholar 

  3. Sandberg DI, Bilsky MH, Kushner BH, Souweidane MM, Kramer K, Laquaglia MP, Panageas KS, Cheung NK. Treatment of spinal involvement in neuroblastoma patients. Pediatr Neurosurg. 2003;39(6):291–8.

    Article  Google Scholar 

  4. Flandin I, Hartmann O, Michon J, Pinkerton R, Coze C, Stephan JL, Fourquet B, Valteau-Couanet D, Bergeron C, Philip T, Carrie C. Impact of TBI on late effects in children treated by megatherapy for Stage IV neuroblastoma. A study of the French Society of Pediatric oncology. Int J Radiat Oncol Biol Phys. 2006;64(5):1424–31.

    Article  Google Scholar 

  5. Armstrong GT, Stovall M, Robison LL. Long-term effects of radiation exposure among adult survivors of childhood cancer: results from the childhood cancer survivor study. Radiat Res. 2010;174(6):840–50.

    Article  CAS  Google Scholar 

  6. Paulino AC, Mayr NA, Simon JH, Buatti JM. Locoregional control in infants with neuroblastoma: role of radiation therapy and late toxicity. Int J Radiat Oncol Biol Phys. 2002;52(4):1025–31.

    Article  Google Scholar 

  7. Maris JM. Recent advances in neuroblastoma. N Engl J Med. 2010;362(23):2202–11.

    Article  CAS  Google Scholar 

  8. Kohler JA, Rubie H, Castel V, Beiske K, Holmes K, Gambini C, Casale F, Munzer C, Erminio G, Parodi S, Navarro S, Marquez C, Peuchmaur M, Cullinane C, Brock P, Valteau-Couanet D, Garaventa A, Haupt R. Treatment of children over the age of one year with unresectable localised neuroblastoma without MYCN amplification: results of the SIOPEN study. Eur J Cancer. 2013;49(17):3671–9.

    Article  CAS  Google Scholar 

  9. Pinto NR, Applebaum MA, Volchenboum SL, Matthay KK, London WB, Ambros PF, Nakagawara A, Berthold F, Schleiermacher G, Park JR, Valteau-Couanet D, Pearson AD, Cohn SL. Advances in risk classification and treatment strategies for neuroblastoma. J Clin Oncol. 2015;33(27):3008–17.

    Article  CAS  Google Scholar 

  10. Smith V, Foster J. High-risk neuroblastoma treatment review. Children (Basel). 2018;5(9) https://doi.org/10.3390/children5090114.

    Article  Google Scholar 

  11. Brisse HJ, McCarville MB, Granata C, Krug KB, Wootton-Gorges SL, Kanegawa K, Giammarile F, Schmidt M, Shulkin BL, Matthay KK, Lewington VJ, Sarnacki S, Hero B, Kaneko M, London WB, Pearson AD, Cohn SL, Monclair T. Guidelines for imaging and staging of neuroblastic tumors: consensus report from the International Neuroblastoma Risk Group Project. Radiology. 2011;261(1):243–57.

    Article  Google Scholar 

  12. Avanzini S, Pio L, Erminio G, Granata C, Holmes K, Gambart M, Buffa P, Castel V, Valteau Couanet D, Garaventa A, Pistorio A, Cecchetto G, Martucciello G, Mattioli G, Sarnacki S. Image-defined risk factors in unresectable neuroblastoma: SIOPEN study on incidence, chemotherapy-induced variation, and impact on surgical outcomes. Pediatr Blood Cancer. 2017;64(11) https://doi.org/10.1002/pbc.26605.

    Article  Google Scholar 

  13. Roth J, Korn A, Bitan-Talmor Y, Kaufman R, Ekstein M, Constantini S. Subcortical mapping using an electrified cavitron ultrasonic aspirator in pediatric supratentorial surgery. World Neurosurg. 2017;101:357–64.

    Article  Google Scholar 

  14. Tang H, Zhang H, Xie Q, Gong Y, Zheng M, Wang D, Zhu H, Chen X, Zhou L. Application of CUSA excel ultrasonic aspiration system in resection of skull base meningiomas. Chin J Cancer Res. 2014;26(6):653–7.

    PubMed  PubMed Central  Google Scholar 

  15. De Bernardi B, Pianca C, Pistamiglio P, Veneselli E, Viscardi E, Pession A, Alvisi P, Carli M, Donfrancesco A, Casale F, Giuliano MG, di Montezemolo LC, Di Cataldo A, Lo Curto M, Bagnulo S, Schumacher RF, Tamburini A, Garaventa A, Clemente L, Bruzzi P. Neuroblastoma with symptomatic spinal cord compression at diagnosis: treatment and results with 76 cases. J Clin Oncol. 2001;19(1):183–90.

    Article  Google Scholar 

  16. Kraal K, Blom T, Tytgat L, van Santen H, van Noesel M, Smets A, Bramer J, Caron H, Kremer L, van der Pal H. Neuroblastoma with intraspinal extension: health problems in long-term survivors. Pediatr Blood Cancer. 2016;63(6):990–6.

    Article  Google Scholar 

  17. Simon T, Niemann CA, Hero B, Henze G, Suttorp M, Schilling FH, Berthold F. Short- and long-term outcome of patients with symptoms of spinal cord compression by neuroblastoma. Dev Med Child Neurol. 2012;54(4):347–52.

    Article  Google Scholar 

  18. Angelini P, Plantaz D, De Bernardi B, Passagia JG, Rubie H, Pastore G. Late sequelae of symptomatic epidural compression in children with localized neuroblastoma. Pediatr Blood Cancer. 2011;57(3):473–80.

    Article  Google Scholar 

  19. Yao KC, McGirt MJ, Chaichana KL, Constantini S, Jallo GI. Risk factors for progressive spinal deformity following resection of intramedullary spinal cord tumors in children: an analysis of 161 consecutive cases. J Neurosurg. 2007;107(6 Suppl):463–8.

    PubMed  Google Scholar 

  20. Trahair T, Sorrentino S, Russell SJ, Sampaio H, Selek L, Plantaz D, Freycon C, Simon T, Kraal K, Beck-Popovic M, Haupt R, Ash S, De Bernardi B. Spinal canal involvement in neuroblastoma. J Pediatr. 2017;188:294–8.

    Article  Google Scholar 

  21. Ozerov SS, Samarin AE, Andreev ES, Tereshchenko GV, Kachanov DY, Shamanskaya TV, Varfolomeeva SR. Neurosurgical aspects of the treatment of neuroblastoma patients. Zh Vopr Neirokhir Im N N Burdenko. 2016;80(3):50–7.

    Article  CAS  Google Scholar 

  22. Menger R, Hefner MI, Savardekar AR, Nanda A, Sin A. Minimally invasive spine surgery in the pediatric and adolescent population: a case series. Surg Neurol Int. 2018;9:116.

    Article  Google Scholar 

  23. Irtan S, Brisse HJ, Minard-Colin V, Schleiermacher G, Canale S, Sarnacki S. Minimally invasive surgery of neuroblastic tumors in children: indications depend on anatomical location and image-defined risk factors. Pediatr Blood Cancer. 2015;62(2):257–61.

    Article  Google Scholar 

  24. Lacreuse I, Valla JS, de Lagausie P, Varlet F, Héloury Y, Temporal G, Bastier R, Becmeur F. Thoracoscopic resection of neurogenic tumors in children. J Pediatr Surg. 2007;42(10):1725–8.

    Article  Google Scholar 

  25. Heloury Y, Muthucumaru M, Panabokke G, Cheng W, Kimber C, Leclair MD. Minimally invasive adrenalectomy in children. J Pediatr Surg. 2012;47(2):415–21.

    Article  Google Scholar 

  26. Mattioli G, Avanzini S, Pini Prato A, Pio L, Granata C, Garaventa A, Conte M, Manzitti C, Montobbio G, Buffa P. Laparoscopic resection of adrenal neuroblastoma without image-defined risk factors: a prospective study on 21 consecutive pediatric patients. Pediatr Surg Int. 2014;30(4):387–94.

    Article  Google Scholar 

  27. Fascetti-Leon F, Scotton G, Pio L, Beltrà R, Caione P, Esposito C, Mattioli G, Saxena AK, Sarnacki S, Gamba P. Minimally invasive resection of adrenal masses in infants and children: results of a European multi-center survey. Surg Endosc. 2017;31(11):4505–12.

    Article  Google Scholar 

  28. Meehan JJ. Robotic surgery for pediatric tumors. Cancer J. 2013;19(2):183–8.

    Article  Google Scholar 

  29. Fraga JC, Rothenberg S, Kiely E, Pierro A. Video-assisted thoracic surgery resection for pediatric mediastinal neurogenic tumors. J Pediatr Surg. 2012;47(7):1349–53.

    Article  Google Scholar 

  30. Mosiello G, Marshall D, Rolle U, Crétolle C, Santacruz BG, Frischer J, Benninga MA. Consensus review of best practice of transanal irrigation in children. J Pediatr Gastroenterol Nutr. 2017;64(3):343–52.

    Article  Google Scholar 

  31. Midrio P, Mosiello G, Ausili E, Gamba P, Marte A, Lombardi L, Iacobelli BD, Caponcelli E, Marrello S, Meroni M, Brisighelli G, Leva E, Rendeli C. Peristeen(®) transanal irrigation in paediatric patients with anorectal malformations and spinal cord lesions: a multicentre Italian study. Color Dis. 2016;18(1):86–93.

    Article  CAS  Google Scholar 

  32. Li Y, Wen Y, He X, Li Y, Wu J, Feng J, Wang Q, Wen J. Application of clean intermittent catheterization for neurogenic bladder in infants less than 1 year old. NeuroRehabilitation. 2018;42(4):377–82.

    Article  Google Scholar 

  33. Sturm RM, Cheng EY. The management of the pediatric neurogenic bladder. Curr Bladder Dysfunct Rep. 2016;11:225–33.

    Article  Google Scholar 

  34. Pio L, Blanc T, de Saint Denis T, Irtan S, Valteau-Couanet D, Michon J, Brisse H, Galmiche-Rolland L, Joyeux L, Odent T, Harte C, Glorion C, Zerah M, Sarnacki S. Multidisciplinary surgical strategy for dumbbell neuroblastoma: a single-center experience of 32 cases. Pediatr Blood Cancer. 2019;2019:e27670.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Pediatric Surgery, Necker - Enfants Malades Hospital, Assistance Publique Hopitaux de Paris, Paris, France

    Luca Pio, Thomas Blanc & Sabine Sarnacki

  2. University of Paris, Paris, France

    Luca Pio, Thomas Blanc, Stephanie Puget, Michel Zerah & Sabine Sarnacki

  3. Department of Orthopaedic Surgery, Hôpital Necker-Enfants Malades, University of Paris, Paris, France

    Christophe Glorion

  4. Department of Pediatric Orthopedics, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France

    Christophe Glorion

  5. Department of Pediatric Neurosurgery, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France

    Stephanie Puget & Michel Zerah

Authors
  1. Luca Pio
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  2. Thomas Blanc
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  3. Christophe Glorion
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  4. Stephanie Puget
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  5. Michel Zerah
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  6. Sabine Sarnacki
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Correspondence to Luca Pio .

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Editors and Affiliations

  1. Department of Pediatric Surgery, Necker - Enfants Malades Hospital, Assistance Publique Hopitaux de Paris, University of Paris, Paris, France

    Sabine Sarnacki

  2. Department of Pediatric Surgery, Necker - Enfants Malades Hospital, Assistance Publique Hopitaux de Paris, University of Paris, Paris, France

    Luca Pio

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Pio, L., Blanc, T., Glorion, C., Puget, S., Zerah, M., Sarnacki, S. (2020). Surgical Strategies for Neuroblastoma with Spinal Canal Involvement. In: Sarnacki, S., Pio, L. (eds) Neuroblastoma. Springer, Cham. https://doi.org/10.1007/978-3-030-18396-7_18

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  • DOI: https://doi.org/10.1007/978-3-030-18396-7_18

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-18395-0

  • Online ISBN: 978-3-030-18396-7

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