Skip to main content
SpringerLink
Log in

Dietary Inflammatory Index in Ageing and Longevity

  • Chapter
  • First Online:
Centenarians

Abstract

Ageing, inflammation and diet represent three interrelated risk factors responsible for the development and worsening of a several diseases including cancer, cardiovascular diseases and metabolic disorders. Specifically, both ageing and diet are able to influence the inflammatory status of the organism through the so-called “inflamm-ageing” and “metaflammation” processes, creating a constant low-grade chronic and systemic inflammation responsible for several molecular alterations.

To establish how diet is able to promote inflammatory processes and consequently influence the development and progression of several diseases and pathophysiological conditions, including ageing and longevity, in recent years, a meter of the pro-inflammatory and anti-inflammatory power of foods, called “Dietary Inflammatory Index” (DII), has been developed.

This chapter discusses how the DII is a powerful instrument to accurately establish the relative risk of developing cardiovascular, metabolic and oncological diseases, taking into account not only the inflammatory power of foods but also the coadjuvant pathogenetic role of ageing in favouring the development of these pathologies. Furthermore, it is also emphasized how DII may influence longevity and healthy ageing.

The comprehensive analysis of the role of inflammation, diet, ageing and longevity and DII in several diseases proposed in this chapter can provide useful information to predict the risk of occurrence of specific diseases.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 16.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 54.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Leon BM, Maddox TM. Diabetes and cardiovascular disease: epidemiology, biological mechanisms, treatment recommendations and future research. World J Diabetes. 2015;6(13):1246–58.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Koene RJ, Prizment AE, Blaes A, Konety SH. Shared risk factors in cardiovascular disease and cancer. Circulation. 2016;133(11):1104–14.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Rose MR, Flatt T, Graves JL, Greer LF, Martinez DE, Matos M, et al. What is aging? Front Genet. 2012;3:134.

    PubMed  PubMed Central  Google Scholar 

  4. Ahmed AS, Sheng MH, Wasnik S, Baylink DJ, Lau KW. Effect of aging on stem cells. World J Exp Med. 2017;7(1):1–10.

    Article  PubMed  PubMed Central  Google Scholar 

  5. López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell. 2013;153(6):1194–217.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  6. Leonardi GC, Accardi G, Monastero R, Nicoletti F, Libra M. Ageing: from inflammation to cancer. Immun Ageing. 2018;15:1.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  7. Accardi G, Caruso C. Immune-inflammatory responses in the elderly: an update. Immun Ageing. 2018;15:11.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Hunter GR, Gower BA, Kane BL. Age related shift in visceral fat. Int J Body Compos Res. 2010;8(3):103–8.

    PubMed  PubMed Central  Google Scholar 

  9. Deng T, Lyon CJ, Bergin S, Caligiuri MA, Hsueh WA. Obesity, inflammation, and cancer. Annu Rev Pathol. 2016;11:421–49.

    Article  CAS  PubMed  Google Scholar 

  10. Suiter C, Singha SK, Khalili R, Shariat-Madar Z. Free fatty acids: circulating contributors of metabolic syndrome. Cardiovasc Hematol Agents Med Chem. 2018;16(1):20–34.

    Article  CAS  PubMed  Google Scholar 

  11. Ellulu MS, Patimah I, Khaza’ai H, Rahmat A, Abed Y. Obesity and inflammation: the linking mechanism and the complications. Arch Med Sci. 2017;13(4):851–63.

    Article  CAS  PubMed  Google Scholar 

  12. Forsythe LK, Wallace JM, Livingstone MB. Obesity and inflammation: the effects of weight loss. Nutr Res Rev. 2008;21(2):117–33.

    Article  CAS  PubMed  Google Scholar 

  13. Gregor MF, Hotamisligil GS. Inflammatory mechanisms in obesity. Annu Rev Immunol. 2011;29:415–45.

    Article  CAS  PubMed  Google Scholar 

  14. Xia S, Zhang X, Zheng S, Khanabdali R, Kalionis B, Wu J, et al. An update on inflamm-aging: mechanisms, prevention, and treatment. J Immunol Res. 2016;2016:8426874.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  15. Frasca D, Blomberg BB, Paganelli R. Aging, obesity, and inflammatory age-related diseases. Front Immunol. 2017;8:1745.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  16. Bottazzi B, Riboli E, Mantovani A. Aging, inflammation and cancer. Semin Immunol. 2018;40:74–82.

    Article  CAS  PubMed  Google Scholar 

  17. Assmann KE, Adjibade M, Shivappa N, Hébert JR, Wirth MD, Touvier M, et al. The inflammatory potential of diet at midlife is associated with later healthy aging in French adults. J Nutr. 2018;148(3):437–44.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Minihane AM, Vinoy S, Russell WR, Baka A, Roche HM, Tuohy KM, et al. Low-grade inflammation, diet composition and health: current research evidence and its translation. Br J Nutr. 2015;114(7):999–1012.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Shivappa N, Steck SE, Hurley TG, Hussey JR, Hebert JR. Designing and developing a literature-derived, population-based dietary inflammatory index. Public Health Nutr. 2014;17(8):1689–96.

    Article  PubMed  Google Scholar 

  20. Cătană CS, Atanasov AG, Berindan-Neagoe I. Natural products with anti-aging potential: affected targets and molecular mechanisms. Biotechnol Adv. 2018;36(6):1649–56.

    Article  PubMed  CAS  Google Scholar 

  21. Muñoz A, Costa M. Nutritionally mediated oxidative stress and inflammation. Oxid Med Cell Longev. 2013;2013:610950.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  22. Tan BL, Norhaizan ME, Liew WP. Nutrients and oxidative stress: friend or foe? Oxid Med Cell Longev. 2018;2018:9719584.

    PubMed  PubMed Central  Google Scholar 

  23. Zhang X, Li J, Sejas DP, Pang Q. The ATM/p53/p21 pathway influences cell fate decision between apoptosis and senescence in reoxygenated hematopoietic progenitor cells. J Biol Chem. 2005;280(20):19635–40.

    Article  CAS  PubMed  Google Scholar 

  24. Sasaki M, Ikeda H, Sato Y, Nakanuma Y. Proinflammatory cytokine-induced cellular senescence of biliary epithelial cells is mediated via oxidative stress and activation of ATM pathway: a culture study. Free Radic Res. 2008;42(7):625–32.

    Article  CAS  PubMed  Google Scholar 

  25. Bartek J, Hodny Z, Lukas J. Cytokine loops driving senescence. Nat Cell Biol. 2008;10(8):887–9.

    Article  CAS  PubMed  Google Scholar 

  26. Soria-Valles C, López-Soto A, Osorio FG, López-Otín C. Immune and inflammatory responses to DNA damage in cancer and aging. Mech Ageing Dev. 2017;165(Pt A):10–6.

    Article  CAS  PubMed  Google Scholar 

  27. Shivappa N, Hebert JR, Rietzschel ER, De Buyzere ML, Langlois M, Debruyne E, et al. Associations between dietary inflammatory index and inflammatory markers in the Asklepios study. Br J Nutr. 2015;113(4):665–71.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Tabung FK, Steck SE, Zhang J, Ma Y, Liese AD, Agalliu I, et al. Construct validation of the dietary inflammatory index among postmenopausal women. Ann Epidemiol. 2015;25(6):398–405.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Shivappa N, Hebert JR, Marcos A, Diaz LE, Gomez S, Nova E, et al. Association between dietary inflammatory index and inflammatory markers in the HELENA study. Mol Nutr Food Res. 2017;61(6):1600707.

    Article  CAS  Google Scholar 

  30. Shivappa N, Hebert JR, Kivimaki M, Akbaraly T. Alternate healthy eating index 2010, dietary inflammatory index and risk of mortality: results from the Whitehall II cohort study and meta-analysis of previous dietary inflammatory index and mortality studies. Br J Nutr. 2017;118(3):210–21.

    Article  CAS  PubMed  Google Scholar 

  31. Alkerwi A, Vernier C, Crichton GE, Sauvageot N, Shivappa N, Hébert JR. Cross-comparison of diet quality indices for predicting chronic disease risk: findings from the observation of cardiovascular risk factors in Luxembourg (ORISCAV-LUX) study. Br J Nutr. 2015;113(2):259–69.

    Article  CAS  PubMed  Google Scholar 

  32. Wirth MD, Hébert JR, Shivappa N, Hand GA, Hurley TG, Drenowatz C, et al. Anti-inflammatory dietary inflammatory index scores are associated with healthier scores on other dietary indices. Nutr Res. 2016;36(3):214–9.

    Article  CAS  PubMed  Google Scholar 

  33. Billingsley HE, Carbone S. The antioxidant potential of the Mediterranean diet in patients at high cardiovascular risk: an in-depth review of the PREDIMED. Nutr Diabetes. 2018;8(1):13.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Hodge AM, Bassett JK, Dugué PA, Shivappa N, Hébert JR, Milne RL, et al. Dietary inflammatory index or Mediterranean diet score as risk factors for total and cardiovascular mortality. Nutr Metab Cardiovasc Dis. 2018;28(5):461–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Accardi G, Shivappa N, Di Maso M, Hébert JR, Fratino L, Montella M, et al. Dietary inflammatory index and cancer risk in elderly: a pooled-analysis of Italian case-control studies. Nutrition. 2019;63–64:205–10.

    Article  PubMed  Google Scholar 

  36. Hernández Morante JJ, Martínez CG, Morillas-Ruiz JM. Dietary factors associated with frailty in old adults: a review of nutritional interventions to prevent frailty development. Nutrients. 2019;11(1):E102.

    Article  PubMed  CAS  Google Scholar 

  37. Kassi E, Pervanidou P, Kaltsas G, Chrousos G. Metabolic syndrome: definition and controversies. BMC Med. 2011;9:48.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Shivappa N, Blair CK, Prizment AE, Jacobs DR Jr, Steck SE, Hébert JR. Association between inflammatory potential of diet and mortality in the Iowa Women’s health study. Eur J Nutr. 2016;55(4):1491–502.

    Article  CAS  PubMed  Google Scholar 

  39. Garcia-Arellano A, Ramallal R, Ruiz-Canela M, Salas-Salvadó J, Corella D, Shivappa N, et al. Dietary inflammatory index and incidence of cardiovascular disease in the PREDIMED study. Nutrients. 2015;7(6):4124–38.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Bondonno NP, Lewis JR, Blekkenhorst LC, Shivappa N, Woodman RJ, Bondonno CP, et al. Dietary inflammatory index in relation to sub-clinical atherosclerosis and atherosclerotic vascular disease mortality in older women. Br J Nutr. 2017;117(11):1577–86.

    Article  CAS  PubMed  Google Scholar 

  41. Shivappa N, Godos J, Hébert JR, Wirth MD, Piuri G, Speciani AF, et al. Dietary inflammatory index and cardiovascular risk and mortality—a meta-analysis. Nutrients. 2018;10(2):E200.

    Article  PubMed  CAS  Google Scholar 

  42. Kawanishi S, Ohnishi S, Ma N, Hiraku Y, Murata M. Crosstalk between DNA damage and inflammation in the multiple steps of carcinogenesis. Int J Mol Sci. 2017;18(8):E1808.

    Article  PubMed  CAS  Google Scholar 

  43. Sui X, Lei L, Chen L, Xie T, Li X. Inflammatory microenvironment in the initiation and progression of bladder cancer. Oncotarget. 2017;8(54):93279–94.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Pimenta AM, Toledo E, Rodriguez-Diez MC, Gea A, Lopez-Iracheta R, Shivappa N, et al. Dietary indexes, food patterns and incidence of metabolic syndrome in a Mediterranean cohort: the SUN project. Clin Nutr. 2015;34(3):508–14.

    Article  CAS  PubMed  Google Scholar 

  45. Neufcourt L, Assmann KE, Fezeu LK, Touvier M, Graffouillère L, Shivappa N, et al. Prospective association between the dietary inflammatory index and metabolic syndrome: findings from the SU.VI.MAX study. Nutr Metab Cardiovasc Dis. 2015;25(11):988–96.

    Article  CAS  PubMed  Google Scholar 

  46. Mazidi M, Shivappa N, Wirth MD, Hebert JR, Mikhailidis DP, Kengne AP, et al. Dietary inflammatory index and cardiometabolic risk in US adults. Atherosclerosis. 2018;276:23–7.

    Article  CAS  PubMed  Google Scholar 

  47. Kim HY, Lee J, Kim J. Association between dietary inflammatory index and metabolic syndrome in the general Korean population. Nutrients. 2018;10(5):E648.

    Article  PubMed  CAS  Google Scholar 

  48. Camargo-Ramos CM, Correa-Bautista JE, Correa-Rodríguez M, Ramírez-Vélez R. Dietary inflammatory index and cardiometabolic risk parameters in overweight and sedentary subjects. Int J Environ Res Public Health. 2017;14(10):E1104.

    Article  PubMed  CAS  Google Scholar 

  49. Ren Z, Zhao A, Wang Y, Meng L, Szeto IMY, Li T, et al. Association between dietary inflammatory index, C-reactive protein and metabolic syndrome: a cross-sectional study. Nutrients. 2018;10(7):E831.

    Article  PubMed  CAS  Google Scholar 

  50. Sokol A, Wirth MD, Manczuk M, Shivappa N, Zatonska K, Hurley TG, et al. Association between the dietary inflammatory index, waist-to-hip ratio and metabolic syndrome. Nutr Res. 2016;36(11):1298–303.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Denova-Gutiérrez E, Muñoz-Aguirre P, Shivappa N, Hébert JR, Tolentino-Mayo L, Batis C, et al. Dietary inflammatory index and type 2 diabetes mellitus in adults: the diabetes mellitus survey of Mexico City. Nutrients. 2018;10(4):382.

    Article  CAS  Google Scholar 

  52. Vahid F, Shivappa N, Karamati M, Naeini AJ, Hébert JR, Davoodi SH. Association between dietary inflammatory index (DII) and risk of prediabetes: a case-control study. Appl Physiol Nutr Metab. 2017;42(4):399–402.

    Article  CAS  PubMed  Google Scholar 

  53. Shivappa N, Harris H, Wolk A, Héberty JR. Association between inflammatory potential of diet and mortality among women in the Swedish mammography cohort. Eur J Nutr. 2016;55(5):1891–900.

    Article  PubMed  Google Scholar 

  54. Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature. 2008;454(7203):436–44. https://doi.org/10.1038/nature07205.

    Article  CAS  PubMed  Google Scholar 

  55. Multhoff G, Molls M, Radons J. Chronic inflammation in cancer development. Front Immunol. 2011;2:98.

    PubMed  Google Scholar 

  56. Landskron G, De la Fuente M, Thuwajit P, Thuwajit C, Hermoso MA. Chronic inflammation and cytokines in the tumor microenvironment. J Immunol Res. 2014;2014:149185.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  57. Zinger A, Cho WC, Ben-Yehuda A. Cancer and aging—the inflammatory connection. Aging Dis. 2017;8(5):611–27.

    Article  PubMed  PubMed Central  Google Scholar 

  58. Sapienza C, Issa JP. Diet, nutrition, and cancer epigenetics. Annu Rev Nutr. 2016;36:665–81.

    Article  CAS  PubMed  Google Scholar 

  59. Mierke CT. The fundamental role of mechanical properties in the progression of cancer disease and inflammation. Rep Prog Phys. 2014;77(7):076602.

    Article  PubMed  CAS  Google Scholar 

  60. Zitvogel L, Pietrocola F, Kroemer G. Nutrition, inflammation and cancer. Nat Immunol. 2017;18(8):843–50.

    Article  CAS  PubMed  Google Scholar 

  61. Thomas F, Rome S, Mery F, Dawson E, Montagne J, Biro PA, et al. Changes in diet associated with cancer: an evolutionary perspective. Evol Appl. 2017;10(7):651–7.

    Article  PubMed  PubMed Central  Google Scholar 

  62. Soldati L, Di Renzo L, Jirillo E, Ascierto PA, Marincola FM, De Lorenzo A. The influence of diet on anti-cancer immune responsiveness. J Transl Med. 2018;16(1):75.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  63. Mazzarella L. Why does obesity promote cancer? Epidemiology, biology, and open questions. Ecancermedicalscience. 2015;9:554.

    Article  PubMed  PubMed Central  Google Scholar 

  64. Hooper L, Anderson AS, Birch J, Forster AS, Rosenberg G, Bauld L, et al. Public awareness and healthcare professional advice for obesity as a risk factor for cancer in the UK: a cross-sectional survey. J Public Health. 2018;40(4):797–805.

    Article  Google Scholar 

  65. IARC Working Group on the Evaluation of Carcinogenic Risk to Humans. Red meat and processed meat. Lyon: International Agency for Research on Cancer; 2018.

    Google Scholar 

  66. Smidowicz A, Regula J. Effect of nutritional status and dietary patterns on human serum C-reactive protein and interleukin-6 concentrations. Adv Nutr. 2015;6(6):738–47.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  67. Vasto S, Buscemi S, Barera A, Di Carlo M, Accardi G, Caruso C. Mediterranean diet and healthy ageing: a Sicilian perspective. Gerontology. 2014;60(6):508–18.

    Article  CAS  PubMed  Google Scholar 

  68. Romagnolo DF, Selmin OI. Mediterranean diet and prevention of chronic diseases. Nutr Today. 2017;52(5):208–22.

    Article  PubMed  PubMed Central  Google Scholar 

  69. Casas R, Sacanella E, Estruch R. The immune protective effect of the Mediterranean diet against chronic low-grade inflammatory diseases. Endocr Metab Immune Disord Drug Targets. 2014;14(4):245–54.

    Article  CAS  PubMed  Google Scholar 

  70. Martucci M, Ostan R, Biondi F, Bellavista E, Fabbri C, Bertarelli C, et al. Mediterranean diet and inflammaging within the hormesis paradigm. Nutr Rev. 2017;75(6):442–55.

    Article  PubMed  PubMed Central  Google Scholar 

  71. Schwingshackl L, Schwedhelm C, Galbete C, Hoffmann G. Adherence to Mediterranean diet and risk of cancer: an updated systematic review and meta-analysis. Nutrients. 2017;9(10):E1063.

    Article  PubMed  CAS  Google Scholar 

  72. Li D, Hao X, Li J, Wu Z, Chen S, Lin J, et al. Dose-response relation between inflammatory index and human cancer risk: evidence from 44 epidemiological studies involving 1,082,092 participants. Am J Clin Nutr. 2018;107(3):371–88.

    Article  PubMed  Google Scholar 

  73. Bray F, Colombet M, Mery L, Piñeros M, Znaor A, Zanetti R and Ferlay J. editors. Cancer incidence in five continents, Vol. XI (electronic version). Lyon: International Agency for Research on Cancer; 2017. http://ci5.iarc.fr. Accessed 14 Jan 2019.

  74. Banna GL, Torino F, Marletta F, Santagati M, Salemi R, Cannarozzo E, et al. Lactobacillus rhamnosus GG: an overview to explore the rationale of its use in cancer. Front Pharmacol. 2017;8:603.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  75. Hamzehzadeh L, Atkin SL, Majeed M, Butler AE, Sahebkar A. The versatile role of curcumin in cancer prevention and treatment: a focus on PI3K/AKT pathway. J Cell Physiol. 2018;233(10):6530–7.

    Article  CAS  PubMed  Google Scholar 

  76. Vivarelli S, Salemi R, Candido S, Falzone L, Santagati M, Stefani S, et al. Gut microbiota and cancer: from pathogenesis to therapy. Cancers (Basel). 2019;11(1). pii: E38.

    Google Scholar 

  77. Falzone L, Salomone S, Libra M. Evolution of cancer pharmacological treatments at the turn of the third millennium. Front Pharmacol. 2018;9:1300.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  78. Tomata Y, Shivappa N, Zhang S, Nurrika D, Tanji F, Sugawara Y, et al. Dietary inflammatory index and disability-free survival in community-dwelling older adults. Nutrients. 2018;10(12):E1896.

    Article  PubMed  Google Scholar 

  79. Shivappa N, Stubbs B, Hébert JR, Cesari M, Schofield P, Soysal P, et al. The relationship between the dietary inflammatory index and incident frailty: a longitudinal cohort study. J Am Med Dir Assoc. 2018;19(1):77–82.

    Article  PubMed  Google Scholar 

  80. Müezzinler A, Zaineddin AK, Brenner H. A systematic review of leukocyte telomere length and age in adults. Ageing Res Rev. 2013;12(2):509–19.

    Article  PubMed  CAS  Google Scholar 

  81. Wong JY, De Vivo I, Lin X, Fang SC, Christiani DC. The relationship between inflammatory biomarkers and telomere length in an occupational prospective cohort study. PLoS One. 2014;9(1):e87348.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  82. García-Calzón S, Zalba G, Ruiz-Canela M, Shivappa N, Hébert JR, Martínez JA, et al. Dietary inflammatory index and telomere length in subjects with a high cardiovascular disease risk from the PREDIMED-NAVARRA study: cross-sectional and longitudinal analyses over 5 y. Am J Clin Nutr. 2015;102(4):897–904.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  83. Shivappa N, Wirth MD, Hurley TG, Hébert JR. Association between the dietary inflammatory index (DII) and telomere length and C-reactive protein from the National Health and Nutrition Examination Survey-1999-2002. Mol Nutr Food Res. 2017;61(4):1600630.

    Article  CAS  Google Scholar 

  84. De Meyer T, Bekaert S, De Buyzere ML, De Bacquer DD, Langlois MR, Shivappa N, et al. Leukocyte telomere length and diet in the apparently healthy, middle-aged Asklepios population. Sci Rep. 2018;8(1):6540.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  85. Freitas-Simoes TM, Ros E, Sala-Vila A. Nutrients, foods, dietary patterns and telomere length: update of epidemiological studies and randomized trials. Metabolism. 2016;65(4):406–15.

    Article  CAS  PubMed  Google Scholar 

  86. Boccardi V, Esposito A, Rizzo MR, Marfella R, Barbieri M, Paolisso G. Mediterranean diet, telomere maintenance and health status among elderly. PLoS One. 2013;8(4):e62781.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  87. Ramallal R, Toledo E, Martínez-González MA, Hernández-Hernández A, García-Arellano A, et al. Dietary inflammatory index and incidence of cardiovascular disease in the SUN cohort. PLoS One. 2015;10(9):e0135221.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  88. Garcia-Arellano A, Martínez-González MA, Ramallal R, Salas-Salvadó J, Hébert JR, Corella D, eSUN and PREDIMED Study Investigators. Dietary inflammatory index and all-causemortality in large cohorts: the SUN and PREDIMED studies. Clin Nutr. 2019;38(3):1221–31.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy

    Luca Falzone & Massimo Libra

  2. Research Center for Prevention, Diagnosis and Treatment of Cancer, University of Catania, Catania, Italy

    Massimo Libra

  3. Unit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy

    Jerry Polesel

Authors
  1. Luca Falzone
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Massimo Libra
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jerry Polesel
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Massimo Libra .

Editor information

Editors and Affiliations

  1. Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Palermo, Italy

    Calogero Caruso

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Falzone, L., Libra, M., Polesel, J. (2019). Dietary Inflammatory Index in Ageing and Longevity. In: Caruso, C. (eds) Centenarians. Springer, Cham. https://doi.org/10.1007/978-3-030-20762-5_5

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-20762-5_5

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-20761-8

  • Online ISBN: 978-3-030-20762-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation