Abstract
Patients with infection caused by unusual or catalase-positive organisms such as Serratia marcescens should be evaluated for chronic granulomatous disease (CGD)
X-linked CGD caused by mutations in CYBB (gp91phox) is the most common form
Dihydrorhodamine test assay has replaced the NBT test as first choice for establishing a diagnosis of CGD
CGD is also a disorder of auto-inflammation, associated with inflammatory bowel disease and lung granuloma
Antibiotic prophylaxis is essential for all CGD patients
Stem cell transplant is curative and should be offered to patients with severe phenotype
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Rodriguez, D., Dunham, M.E., Wall, L.A. (2019). Failure to Thrive and Nasal Obstruction. In: Rezaei, N. (eds) Pediatric Immunology. Springer, Cham. https://doi.org/10.1007/978-3-030-21262-9_62
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