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Osteosarcopenia: Bone, Muscle and Fat Interactions pp 191–213Cite as

Calciotropic Hormones and Osteosarcopenia

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Abstract

Increase in life expectancy and decrease in mortality associated with a decrease in physical activity leads to population aging and the development of certain age-related pathologies such as osteoporosis and sarcopenia. These two conditions are very often linked and denominated under the same term: osteosarcopenia. There is an interconnection between muscle and bone permitted by hormonal mediators. Involvement of hormones and calciotropic proteins in osteosarcopenia involves especially vitamin D, parathyroid hormone, osteocalcin, leptin, and gonadal steroid causing changes in bone and muscle structure and function. Osteosarcopenia is a particularly deleterious condition in older persons, increasing the risk of serious health events and reducing life expectancy. Calciotropic hormonal changes would identify people at risk and influence the evolution of health status of these people.

This Chapter presents an inventory of current knowledge concerning the involvement of main calciotropic hormones in muscular and bone health of osteosarcopenic or at-risk patients.

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Authors and Affiliations

  1. Department of Neuroscience, Division of Geriatric Medicine; Angers University Hospital, University Memory Clinic of Angers, Angers, France

    Guillaume T. Duval, Hélène Meytadier & Cédric Annweiler

  2. Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, the University of Western Ontario, London, ON, Canada

    Cédric Annweiler

  3. Australian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health, St. Albans, VIC, Australia

    Gustavo Duque

  4. Department of Medicine-Western Health, Melbourne Medical School, The University of Melbourne, St. Albans, VIC, Australia

    Gustavo Duque

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  1. Guillaume T. Duval
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  2. Hélène Meytadier
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  3. Cédric Annweiler
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  4. Gustavo Duque
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Correspondence to Guillaume T. Duval .

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  1. Australian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health, St. Albans, VIC, Australia, Department of Medicine-Western Health, Melbourne Medical School, The University of Melbourne, St. Albans, VIC, Australia

    Gustavo Duque

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Duval, G.T., Meytadier, H., Annweiler, C., Duque, G. (2019). Calciotropic Hormones and Osteosarcopenia. In: Duque, G. (eds) Osteosarcopenia: Bone, Muscle and Fat Interactions. Springer, Cham. https://doi.org/10.1007/978-3-030-25890-0_9

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