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Emerging Roles for Interleukin-18 in the Gastrointestinal Tumor Microenvironment

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Tumor Microenvironment

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1240))

Abstract

Interleukin (IL)-18, a member of the IL-1 family of cytokines, has emerged as a key regulator of mucosal homeostasis within the gastrointestinal tract. Like other members of this family, IL-18 is secreted as an inactive protein and is processed into its active form by caspase-1, although other contributors to precursor processing are emerging.

Numerous studies have evaluated the role of IL-18 within the gastrointestinal tract using genetic or complementary pharmacological tools and have revealed multiple roles in tumorigenesis. Most striking among these are the divergent roles for IL-18 in colon and gastric cancers. Here, we review our current understanding of IL-18 biology and how this applies to colorectal and gastric cancers.

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Acknowledgments

The Walter and Eliza Hall Institute receives funding from the Victorian State Government Operational Infrastructure Support Program. TLP receives funding from the National Health and Medical Research Council (NHMRC) of Australia Project Grants (1080498, 1098643). TLP is a Victorian Cancer Agency Fellow and WEHI Dyson Bequest Centenary Fellow.

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The authors declare no conflicts.

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Authors and Affiliations

  1. Personalized Oncology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia

    Ka Yee Fung, Paul M. Nguyen & Tracy L. Putoczki

  2. Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia

    Tracy L. Putoczki

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Correspondence to Tracy L. Putoczki .

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  1. Department of Radiology, Columbia University Medical Center, New York, NY, USA, Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

    Alexander Birbrair

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Fung, K.Y., Nguyen, P.M., Putoczki, T.L. (2020). Emerging Roles for Interleukin-18 in the Gastrointestinal Tumor Microenvironment. In: Birbrair, A. (eds) Tumor Microenvironment. Advances in Experimental Medicine and Biology, vol 1240. Springer, Cham. https://doi.org/10.1007/978-3-030-38315-2_5

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