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Wnt Signaling in the Tumor Microenvironment

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1270))

Abstract

Dysregulated Wnt signaling plays a central role in initiation, progression, and metastasis in many types of human cancers. Cancer development and resistance to conventional cancer therapies are highly associated with the tumor microenvironment (TME), which is composed of numerous stable non-cancer cells, including immune cells, extracellular matrix (ECM), fibroblasts, endothelial cells (ECs), and stromal cells. Recently, increasing evidence suggests that the relationship between Wnt signaling and the TME promotes the proliferation and maintenance of tumor cells, including leukemia. Here, we review the Wnt pathway, the role of Wnt signaling in different components of the TME, and therapeutic strategies for targeting Wnt signaling.

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Authors and Affiliations

  1. Department of Pediatrics, Division of Hematology, Oncology, Blood and Marrow Transplantation, Children’s Hospital Los Angeles, University of Southern California, Los Angeles, CA, USA

    Yongsheng Ruan, Heather Ogana, Eunji Gang, Hye Na Kim & Yong-Mi Kim

  2. Department of Pediatrics, Nanfang Hospital, Southern Medical University, Guangzhou, China

    Yongsheng Ruan

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Correspondence to Yong-Mi Kim .

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  1. Department of Radiology, Columbia University Medical Center, New York, NY, USA, Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

    Alexander Birbrair

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Ruan, Y., Ogana, H., Gang, E., Kim, H.N., Kim, YM. (2021). Wnt Signaling in the Tumor Microenvironment. In: Birbrair, A. (eds) Tumor Microenvironment. Advances in Experimental Medicine and Biology, vol 1270. Springer, Cham. https://doi.org/10.1007/978-3-030-47189-7_7

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