Abstract
Sex-related differences in lung growth exist and result in differences in lung function during the prenatal period and across the life span. This translates into disparity in the susceptibility and severity of several lung diseases. In general, lung diseases, such as acute respiratory distress and bronchopulmonary dysplasia, are worse in males during the neonatal period and during childhood. After puberty, women are affected more than men by lung diseases, such as asthma and cystic fibrosis. Lung function and disease severity also fluctuate with the menstrual cycle; abundant evidence suggests a benefit of androgens. Understanding sex-related differences in lung development and their impact on lung disease is important to predict outcomes and provide sex-based personalized management plans across the life span.
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Zein, J.G., Gaston, B. (2021). Sex Differences in the Developing Lung: Implications for Disease. In: Silveyra, P., Tigno, X.T. (eds) Sex-Based Differences in Lung Physiology. Physiology in Health and Disease. Springer, Cham. https://doi.org/10.1007/978-3-030-63549-7_4
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