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The Microbiome and Urologic Cancers

In “Inflammation, Infection, and Microbiome in Cancers: Evidence, Mechanisms, and Implications”

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Inflammation, Infection, and Microbiome in Cancers

Part of the book series: Physiology in Health and Disease ((PIHD))

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Abstract

Cancers of the urinary system are likely to be influenced by both the urinary and gut microbiotas. While commensal organisms do not densely colonize the urinary system, those present still play a significant role in health and disease. Like other organs, there is always a potential for malignancy to occur when microorganisms cause chronic inflammation. Additionally, the urinary system is commonly exposed to the waste products in the body, including those microbial metabolites from the gut which have entered the circulation. It is, therefore, possible that the microbiota of different sites contributes to the process of carcinogenesis through metabolic toxification and detoxification as well as immune interactions. The emerging clinical evidence also suggests a prominent role for microbiota in affecting the efficacy of cancer therapeutics, including chemotherapy and immunotherapy agents.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, University of Western Ontario, London, ON, Canada

    Mithunah Krishnamoorthy & Jeremy P. Burton

  2. Cancer Research Laboratory Program, Lawson Health Research Institute, London, ON, Canada

    Mithunah Krishnamoorthy & Saman Maleki Vareki

  3. Department of Pathology and Laboratory Medicine, University of Western Ontario, London, ON, Canada

    Saman Maleki Vareki

  4. Division of Experimental Oncology, Department of Oncology, University of Western Ontario, London, ON, Canada

    Saman Maleki Vareki

  5. Canadian Centre for Human Microbiome and Probiotics, London, ON, Canada

    Saman Maleki Vareki & Jeremy P. Burton

  6. Division of Urology, Department of Surgery, University of Western Ontario, London, ON, Canada

    Jeremy P. Burton

Authors
  1. Mithunah Krishnamoorthy
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  2. Saman Maleki Vareki
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  3. Jeremy P. Burton
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Correspondence to Jeremy P. Burton .

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Editors and Affiliations

  1. Jesse Brown VA Medical Center Chicago (537), Chicago, IL, USA

    Jun Sun

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Krishnamoorthy, M., Maleki Vareki, S., Burton, J.P. (2021). The Microbiome and Urologic Cancers. In: Sun, J. (eds) Inflammation, Infection, and Microbiome in Cancers. Physiology in Health and Disease. Springer, Cham. https://doi.org/10.1007/978-3-030-67951-4_8

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