Skip to main content

Infectious Arthritis

  • Chapter
  • First Online:
Rheumatology for Primary Care Providers

Abstract

The osteoarticular system can be infected by bacteria, viruses, fungi, and protozoa. Bacterial joint infections typically present with acute redness and swelling of the infected joint; the most common cause is Staphylococcus aureus. Other bacterial infections can present more atypically. Disseminated gonococcal infection often causes a polyarticular infection with prominent involvement of the tenosynovium, along with a characteristic purpuric rash. Lyme arthritis can present with a migratory, relapsing-remitting course. Viruses can cause arthralgias but uncommonly affect the joint themselves. The exception is parvovirus which can present with a rheumatoid-arthritis like picture in adults, as well as chikungunya virus that presents with acute polyarticular synovitis in a patient with an appropriate travel history. Tuberculosis is a common cause of osteoarticular infection in many parts of the world though uncommon in the United States. Fungal infections should be considered in immunocompromised patients.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Dubost JJ, Couderc M, Tatar Z, et al. Three-decade trend in the distribution of organisms causing septic arthritis in native joints. Joint Bone Spine. 2014;81(5):438–40.

    Article  PubMed  Google Scholar 

  2. Kaandorp CJ, Dinant HJ, van de Laar MA, et al. Incidence and sources of native and prosthetic joint infection: a community based prospective survey. Ann Rheum Dis. 1997;56:470–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Dubost JJ, Fis I, Denis P, et al. Polyarticular septic arthritis. Medicine (Baltimore). 1993;72:296–310.

    Article  CAS  Google Scholar 

  4. Rutherford AI, et al. A population study of the reported incidence of native joint septic arthritis in the United Kingdom between 1998 and 2013. Rheumatology (Oxford). 2016;55(12):2176–80.

    Article  Google Scholar 

  5. Weston VC, Jones AC, Bradbury N, et al. Clinical features and outcome of septic arthritis in a single UK Health District 1982–1991. Ann Rheum Dis. 1999;58:214–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Margaretten ME, Kohlwes J, Moore D, Bent S. Does this adult patient have septic arthritis? JAMA. 2007;297(13):1478–88.

    Article  CAS  PubMed  Google Scholar 

  7. Ross JJ. Septic arthritis of native joints. Infect Dis Clin N Am. 2017;31(2):203–18.

    Article  Google Scholar 

  8. Kaandorp CJ, Krijnen P, Moens HJ, Habbema JD, van Schaardenburg D. The outcome of bacterial arthritis: a prospective community-based study. Arthritis Rheum. 1997;40(5):884–92.

    Article  CAS  PubMed  Google Scholar 

  9. O’Brien JP, Goldenberg DL, Rice PA. Disseminated gonococcal infection: a prospective analysis of 49 patients and a review of pathophysiology and immune mechanisms. Medicine (Baltimore). 1983;62(6):395–406.

    Article  Google Scholar 

  10. Ghosn SH, Kibbi A-G. Cutaneous gonococcal infections. Clin Dermatol. 2004;22:476–80.

    Article  PubMed  Google Scholar 

  11. Rice PA. Gonococcal arthritis (disseminated gonococcal infection). Infect Dis Clin N Am. 2005;19(4):853–61.

    Article  Google Scholar 

  12. Unemo M, Seifert HS, Hook EW 3rd, Hawkes S, Ndowa F, Dillon JR. Gonorrhoea. Nat Rev Dis Primers. 2019;5(1):79.

    Article  Google Scholar 

  13. Veasy LG, Wiedmeier SE, Orsmond GS, Ruttenberg HD, Boucek MM, Roth SJ, Tait F, Thompson JA, Daly JA, Kaplan EL, et al. Resurgence of acute rheumatic fever in the intermountain area of the United States. N Engl J Med. 1987;316(8):421–7.

    Article  CAS  PubMed  Google Scholar 

  14. Steer AC, Smeesters PR, Curtis N. Streptococcal serology: secrets for the specialist. Pediatr Infect Dis J. 2015;34(11):1250–2.

    Article  PubMed  Google Scholar 

  15. Karthikeyan G, Guilherme L. Acute rheumatic fever. Lancet. 2018;392(10142):161–74.

    Article  PubMed  Google Scholar 

  16. Gewitz MH, Baltimore RS, Tani LY, Sable CA, Shulman ST, Carapetis J, Remenyi B, Taubert KA, Bolger AF, Beerman L, Mayosi BM, Beaton A, Pandian NG, Kaplan EL, American Heart Association Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease of the Council on Cardiovascular Disease in the Young. Revision of the Jones Criteria for the diagnosis of acute rheumatic fever in the era of Doppler echocardiography: a scientific statement from the American HeartAssociation. Circulation. 2015;131(20):1806–18.

    Article  PubMed  Google Scholar 

  17. Roth GA, Huffman MD, Moran AE, Feigin V, Mensah GA, Naghavi M, Murray CJ. Global and regional patterns in cardiovascular mortality from 1990 to 2013. Circulation. 2015;132(17):1667–78.

    Article  PubMed  Google Scholar 

  18. John TM, Taege AJ. Appropriate laboratory testing in Lyme disease. Cleve Clin J Med. 2019;86(11):751–9.

    Article  PubMed  Google Scholar 

  19. Schoen RT. Challenges in the diagnosis and treatment of Lyme disease. Curr Rheumatol Rep. 2020;22(1):3.

    Article  PubMed  Google Scholar 

  20. Steere AC, Schoen RT, Taylor E. The clinical evolution of Lyme arthritis. Ann Intern Med. 1987;107(5):725–31.

    Article  CAS  PubMed  Google Scholar 

  21. Bockenstedt LK, Wormser GP. Review: unraveling Lyme disease. Arthritis Rheumatol. 2014;66(9):2313–23.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Mead P, Petersen J, Hinckley A. Updated CDC recommendation for serologic diagnosis of Lyme disease. MMWR Morb Mortal Wkly Rep. 2019;68:703.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Reid MC, Schoen RT, Evans J, Rosenberg JC, Horwitz RI. The consequences of over diagnosis and overtreatment of Lyme disease: an observational study. Ann Intern Med. 1998;128(5):354–62.

    Article  CAS  PubMed  Google Scholar 

  24. Lochhead RB, Strle K, Kim ND, Kohler MJ, Arvikar SL, Aversa JM, Steere AC. MicroRNA expression shows inflammatory dysregulation and tumor-like proliferative responses in joints of patients with postinfectious Lyme arthritis. Arthritis Rheumatol. 2017;69(5):1100–10.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Cerar D, Cerar T, Ruzić-Sabljić E, Wormser GP, Strle F. Subjective symptoms after treatment of early Lyme disease. Am J Med. 2010;123(1):79–86.

    Article  PubMed  Google Scholar 

  26. Melia MT, Auwaerter PG. Time for a different approach to Lyme disease and long-term symptoms. N Engl J Med. 2016;374(13):1277–8.

    Article  CAS  PubMed  Google Scholar 

  27. Feder HM Jr, Johnson BJ, O'Connell S, Shapiro ED, Steere AC, Wormser GP, AdHoc International Lyme Disease Group, Agger WA, Artsob H, Auwaerter P, Dumler JS, Bakken JS, Bockenstedt LK, Green J, Dattwyler RJ, Munoz J, Nadelman RB, Schwartz I, Draper T, McSweegan E, Halperin JJ, Klempner MS, Krause PJ, Mead P, Morshed M, Porwancher R, Radolf JD, Smith RP Jr, Sood S, Weinstein A, Wong SJ, Zemel L. A critical appraisal of “chronic Lyme disease”. N Engl J Med. 2007;357(14):1422–30.

    Article  CAS  PubMed  Google Scholar 

  28. Yazdany J, Schmajuk G, Robbins M, Daikh D, Beall A, Yelin E, Barton J, Carlson A, Margaretten M, Zell J, Gensler LS, Kelly V, Saag K, King C, American College of Rheumatology Core Membership Group. Choosing wisely: the American College of Rheumatology’s top 5 list of things physicians and patients should question. Arthritis Care Res (Hoboken). 2013;65(3):329–39.

    Article  Google Scholar 

  29. Vu DM, Jungkind D, LaBeaud AD. Chikungunya virus. Clin Lab Med. 2017;37(2):371–82.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Weaver SC, Lecuit M. Chikungunya virus infections. N Engl J Med. 2015;373(1):94–5.

    CAS  PubMed  Google Scholar 

  31. Lindsey NP, Staples JE, Fischer M. Chikungunya virus disease among travelers-United States, 2014–2016. Am J Trop Med Hyg. 2018;98(1):192–7.

    Article  PubMed  Google Scholar 

  32. Hyle EP, Alame D. Case records of the Massachusetts General Hospital. Case 13-2015. A 27-year-old woman with arthralgias and a rash. N Engl J Med. 2015;372(17):1657–64.

    Article  CAS  PubMed  Google Scholar 

  33. Amaral JK, Bilsborrow JB, Schoen RT. Chronic chikungunya arthritis and rheumatoid arthritis: what they have in common. Am J Med. 2020;133(3):e91–7.

    Article  CAS  PubMed  Google Scholar 

  34. Chang AY, KAO M, Encinales L, Reid SP, Acuña M, Encinales C, Matranga CB, Pacheco N, Cure C, Shukla B, Ruiz Arteta T, Amdur R, Cazares LH, Gregory M, Ward MD, Porras A, Rico Mendoza A, Dong L, Kenny T, Brueggemann E, Downey LG, Kamalapathy P, Lichtenberger P, Falls O, Simon GL, Bethony JM, Firestein GS. Chikungunya arthritis mechanisms in the Americas: a cross-sectional analysis of chikungunya arthritis patients twenty-two months after infection demonstrating no detectable viral persistence in synovial fluid. Arthritis Rheumatol. 2018;70(4):585–93.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Malvy D, Ezzedine K, Mamani-Matsuda M, et al. Destructive arthritis in a patient with chikungunya virus infection with persistent specific IgM antibodies. BMC Infect Dis. 2009;9:200.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Amaral JK, Sutaria R, Schoen RT. Treatment of chronic chikungunya arthritis with methotrexate: a systematic review. Arthritis Care Res (Hoboken). 2018;70(10):1501–8.

    Article  PubMed  Google Scholar 

  37. Moore TL. Parvovirus-associated arthritis. Curr Opin Rheumatol. 2000;12:289–94.

    Article  CAS  PubMed  Google Scholar 

  38. Speyer I, Breedveld FC, Dijkmans BA. Human parvovirus B19 infection is not followed by inflammatory joint disease during long term follow-up. A retrospective study of 54 patients. Clin Exp Rheumatol. 1998;16(5):576–8.

    CAS  PubMed  Google Scholar 

  39. World Health Organization. HIV-associated tuberculosis. https://www.who.int/tb/areas-of-work/tb-hiv/tbhiv_factsheet.pdf?ua=1. Accessed 10 July 2020.

  40. Johansen IS, Nielsen SL, Hove M, Kehrer M, Shakar S, Wøyen AV, Andersen PH, Bjerrum S, Wejse C, Andersen ÅB. Characteristics and clinical outcome of bone and joint tuberculosis from 1994 to 2011: a retrospective register-based study in Denmark. Clin Infect Dis. 2015;61(4):554–62.

    Article  PubMed  Google Scholar 

  41. Shu CC, Wang JY, Yu CJ, Lee LN. Mycobacterial arthritis of large joints. AnnRheum Dis. 2009;68(9):1504–5.

    Article  Google Scholar 

  42. Nahid P, Dorman SE, Alipanah N, Barry PM, Brozek JL, Cattamanchi A, Chaisson LH, Chaisson RE, Daley CL, Grzemska M, Higashi JM, Ho CS, Hopewell PC, Keshavjee SA, Lienhardt C, Menzies R, Merrifield C, Narita M, O'Brien R, Peloquin CA, Raftery A, Saukkonen J, Schaaf HS, Sotgiu G, Starke JR, Migliori GB, Vernon A. Official American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America clinical practice guidelines: treatment of drug-susceptible tuberculosis. Clin Infect Dis. 2016;63(7):e147–95.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Daniel Bunker .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2022 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Bunker, D., Balba, G.P. (2022). Infectious Arthritis. In: Ali, Y. (eds) Rheumatology for Primary Care Providers. Springer, Cham. https://doi.org/10.1007/978-3-030-80699-6_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-80699-6_11

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-80698-9

  • Online ISBN: 978-3-030-80699-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics