Abstract
Undoubtedly, the increase in the incidence of many chronic diseases, especially metabolic syndrome, is related to an unhealthy diet. “Natural-organic nutrition,” which is one of the important elements of a healthy life, will also minimize the entry of “exogenous free radicals” into the body, which are accepted as oxidative stress factors in human metabolism. Recently, the thiol-disulfide balance has been accepted as an indicator for oxidative stress, which is the root cause of most diseases. Among these systemic diseases, metabolic syndrome, cancer, rheumatoid arthritis, type II diabetes, Parkinson’s, Alzheimer’s, cardiovascular diseases, migraine, liver, and kidney failure are the first ones that come to mind. Many factors, including obesity, oxidative stress and unhealthy diet are involved in the etiopathogenesis of many diseases. In this section, the relationship between nutrition and thiol-disulfide homeostasis, which is one of the oxidative stress markers, is presented.
This is a preview of subscription content, log in via an institution to check access.
Abbreviations
- AA:
-
Acute appendicitis
- Cd:
-
Cardiovascular diseases
- Cr:
-
Circadian rhythm
- Crf:
-
Chronic renal failure
- Dm:
-
Diabetes mellitus
- Dn:
-
Diabetic nephropathy
- Fr:
-
Free radicals
- GM:
-
Gut microbiome
- Gmo:
-
Genetically modified organisms
- HL:
-
Healthy life
- IF:
-
Intermittent fasting
- L:
-
Lifestyle
- Lbp:
-
Lipopolysaccharide-binding protein
- Nos:
-
Nitric oxide synthase
- Ntl:
-
Native thiol
- O:
-
Obesity
- On:
-
Organic nutrition
- Os:
-
Oxidative stress
- Ra:
-
Rheumatoid arthritis
- S:
-
Sleep
- Tdh:
-
Thiol-disulfide homeostasis
- Ttl:
-
Total thiol
- WHO:
-
World Health Organization
References
Acar Atılgan B, Acar T, Yazar H, et al. Evaluation of dynamic thiol/disulphide homoeostasis in acute ischemic stroke. Acta Med Mediterr. 2021;37(1):533–9. https://doi.org/10.19193/0393-6384_2021_1_83.
Alagöz A, Can N, Yazar H, et al. Thiol-disulfide homeostasis in idiopathic Parkinson’s disease. Kafkas J Med Sci. 2020;10(1):39–45. https://doi.org/10.5505/kjms.2020.03743.
Altiparmak IH, Erkus ME, Sezen H, et al. Evaluation of thiol levels, thiol/disulfide homeostasis and their relation with inflammation in cardiac syndrome X. Coron Artery Dis. 2016;27(4):295–301. https://doi.org/10.1097/MCA.0000000000000362.
Anton SD, Moehl K, Donahoo WT, et al. Flipping the metabolic switch: understanding and applying the health benefits of fasting. Obesity. 2018;26(2):254–68. https://doi.org/10.1002/oby.22065.
Ateş I, Kaplan M, Yuksel M, et al. Determination of thiol/disulphide homeostasis in type 1 diabetes mellitus and the factors associated with thiol oxidation. Endocrine. 2016a;51(1):47–51. https://doi.org/10.1007/s12020-015-0784-6.
Ateş İ, Ozkayar N, Altay M, et al. Is disulphide/thiol ratio related to blood pressure in masked hypertension? Clin Exp Hypertens. 2016b;38(2):150–4. https://doi.org/10.3109/10641963.2015.1060995.
Bjorklund G, Chirumbolo S. Role of oxidative stress and antioxidants in daily nutrition and human health. Nutrition. 2017;33:311–21. https://doi.org/10.1016/j.nut.2016.07.018.
Cao C, Xiao Z, Wu Y, et al. Diet and skin aging-from the perspective of food nutrition. Nutrients. 2020;12(3):870. https://doi.org/10.3390/nu12030870.
Corsello A, Pugliese D, Gasbarrini A, et al. Diet and nutrients in gastrointestinal chronic diseases. Nutrients. 2020;12(9):2693. https://doi.org/10.3390/nu12092693.
Dertli R, Keskin M, Bıyık M, et al. Dynamic thiol-disulfide homeostasis is disturbed in hepatitis B virus-related chronic hepatitis and liver cirrhosis. Turk J Med Sci. 2018;48(5):985–92. https://doi.org/10.3906/sag-1803-135.
Douglas LC, Sanders ME. Probiotics and prebiotics in dietetics practice. J Am Diet Assoc. 2008;108(3):510–21. https://doi.org/10.1016/j.jada.2007.12.009.
Elmas B, Yildiz T, Yazar H, et al. New oxidative stress markers useful in the diagnosis of acute appendicitis in children: thiol/disulfide homeostasis and the asymmetric dimethylarginine level. Pediatr Emerg Care. 2020;36(8):362–7. https://doi.org/10.1097/PEC.0000000000001339.
Emre S, Demirseren DD, Alisik M, et al. Dynamic thiol/disulfide homeostasis and effects of smoking on homeostasis parameters in patients with psoriasis. Cutan Ocul Toxicol. 2017;36(4):393–6. https://doi.org/10.1080/15569527.2017.1311339.
Emre S, Kalkan G, Erdoğan S, et al. Dynamic thiol/disulfide balance in patients with seborrheic dermatitis: a case-control study. Saudi J Med Med Sci. 2020;8(1):12–6. https://doi.org/10.4103/sjmms.sjmms_50_19.
Ercan Haydar FG, Otal Y, Şener A, et al. The thiol-disulphide homeostasis in patients with acute pancreatitis and its relation with other blood parameters. Ulus Travma Acil Cerrahi Derg. 2020;26(1):37–42. https://doi.org/10.14744/tjtes.2019.38969.
Erel O, Neselioglu S. A novel and automated assay for thiol/disulphide homeostasis. Clin Biochem. 2014;47(18):326–32. https://doi.org/10.1016/j.clinbiochem.2014.09.026.
Fang YZ, Yang S, Wu G. Free radicals, antioxidants, and nutrition. Nutrition. 2002;18(10):872–9. https://doi.org/10.1016/s0899-9007(02)00916-4.
Gulpamuk B, Elgin U, Sen E, et al. Evaluation of dynamic thiol-disulfide homeostasis in glaucoma patients and the correlation with retinal nerve fiber layer analysis. Eur J Ophthalmol. 2020;30(4):690–9. https://doi.org/10.1177/1120672119839582.
Gumusyayla S, Vural G, Bektas H, et al. Erratum to. A novel oxidative stress marker in migraine patients: dynamic thiol-disulphide homeostasis. Neurol Sci. 2016a;37(8):1381. https://doi.org/10.1007/s10072-016-2617-7.
Gumusyayla S, Vural G, Bektas H, et al. A novel oxidative stress marker in patients with Alzheimer’s disease: dynamic thiol-disulphide homeostasis. Acta Neuropsychiatr. 2016b;28(6):315–20. https://doi.org/10.1017/neu.2016.13.
Gündüztepe Y, Bukan N, Zorlu E, et al. The evaluation of thiol-disulfite balance, ischemıa albumın modıfıcation and seruloplazmine as a new oxidatıve stress in mild cognitive impairment and early stage Alzheimer’s disease patients. J Clin Neurosci. 2020;75:188–94. https://doi.org/10.1016/j.jocn.2019.12.026.
Guney T, Kanat IF, Alkan A, et al. Assessment of serum thiol/disulfide homeostasis in multiple myeloma patients by a new method. Redox Rep. 2016;19:1–6. https://doi.org/10.1080/13510002.2016.1180100.
Hannou SA, Haslam DE, McKeown NM, et al. Fructose metabolism and metabolic disease. J Clin Invest. 2018;128(2):545–55. https://doi.org/10.1172/JCI96702.
Iddir M, Brito A, Dingeo G, et al. Strengthening the immune system and reducing inflammation and oxidative stress through diet and nutrition: considerations during the COVID-19 crisis. Nutrients. 2020;12(6):1562. https://doi.org/10.3390/nu12061562.
Jonas DE, Amick HR, Feltner C, et al. Pharmacotherapy for adults with alcohol use disorders in outpatient settings: a systematic review and meta-analysis. JAMA. 2014;311(18):1889–900. https://doi.org/10.1001/jama.2014.3628.
Karacan G, Ercan N, Bostanci I, et al. A novel oxidative stress marker of atopic dermatitis in infants: thiol-disulfide balance. Arch Dermatol Res. 2020;312(10):697–703. https://doi.org/10.1007/s00403-020-02054-5.
Kayacan Y, Yazar H, et al. A novel biomarker explaining the role of oxidative stress in exercise and l-tyrosine supplementation: thiol/disulphide homeostasis. Arch Physiol Biochem. 2018;124(3):232–6. https://doi.org/10.1080/13813455.2017.1388410.
Kayacan Y, Çetinkaya A, Yazar H, et al. Oxidative stress response to different exercise intensity with an automated assay: thiol/disulphide homeostasis. Arch Physiol Biochem. 2019a;14:1–5. https://doi.org/10.1080/13813455.2019.1651868.
Kayacan Y, Yazar H, Cerit G, et al. A new oxidative stress indicator: effect of 5-hydroxytryptophan on thiol-disulfide homeostasis in exercise. Nutrition. 2019b;64:114–9. https://doi.org/10.1016/j.nut.2019.01.013.
Khanna K, Raymond W, Charbit AR, et al. Binding of SARS-CoV-2 spike protein to ACE2 is disabled by thiol-based drugs; evidence from in vitro SARS-CoV-2 infection studies. bioRxiv. 2020. https://doi.org/10.1101/2020.12.08.415505.
Kim MJ, Ainsley JA, Carder JW, et al. Hyperoxia-triggered aversion behavior in Drosophila foraging larvae is mediated by sensory detection of hydrogen peroxide. J Neurogenet. 2013;27(4):151–62. https://doi.org/10.3109/01677063.2013.804920.
Kundi H, Ates I, Kiziltunc E, et al. A novel oxidative stress marker in acute myocardial infarction; thiol/disulphide homeostasis. Am J Emerg Med. 2015;33(11):1567–71. https://doi.org/10.1016/j.ajem.2015.06.016.
Lessan N, Ali T. Energy metabolism and intermittent fasting: the Ramadan perspective. Nutrients. 2019;11(5):1192. https://doi.org/10.3390/nu11051192.
Lushchak VI. Free radicals, reactive oxygen species, oxidative stress and its classification. Chem Biol Interact. 2014;224:164–75. https://doi.org/10.1016/j.cbi.2014.10.016.
Mete AÖ, Koçak K, Saracaloglu A, et al. Effects of antiviral drug therapy on dynamic thiol/disulphide homeostasis and nitric oxide levels in COVID-19 patients. Eur J Pharmacol. 2021;907:174306. https://doi.org/10.1016/j.ejphar.2021.174306.
Moriarty-Craige SE, Jones DP. Extracellular thiols and thiol/disulfide redox in metabolism. Annu Rev Nutr. 2004;24:481–509. https://doi.org/10.1146/annurev.nutr.24.012003.132208.
Mozaffarian D. Dietary and policy priorities for cardiovascular disease, diabetes, and obesity: a comprehensive review. Circulation. 2016;133(2):187–225. https://doi.org/10.1161/CIRCULATIONAHA.115.018585.
Noctor G, Queval G, Mhamdi A, et al. Glutathione. Arabidopsis Book. 2011;9:e0142. https://doi.org/10.1199/tab.0142. Epub 2011 Feb 18
Or KA, Dağdeviren M, Akkan T, et al. Dynamic thiol/disulfide homeostasis and oxidant status in patients with hypoparathyroidism. J Med Biochem. 2020;39(2):231–9. https://doi.org/10.2478/jomb-2019-0036.
Orhan M, Taş Tuna A, Ünal Y, et al. The effects of amantadine on lung tissue in lower limb ischemia/reperfusion injury model in rats. Turk Gogus Kalp Damar Cerrahisi Derg. 2021;29(1):77–83. https://doi.org/10.5606/tgkdc.dergisi.2021.19884.
Ozler S, Oztas E, Caglar AT, et al. Thiol/disulfide homeostasis in predicting adverse perinatal outcomes at 24–28 weeks of pregnancy in gestational diabetes. J Matern Fetal Neonatal Med. 2016;29(22):3699–704. https://doi.org/10.3109/14767058.2016.1141885.
Ozyazici S, Karateke F, Turan U, et al. A novel oxidative stress mediator in acute appendicitis: thiol/disulphide homeostasis. Mediat Inflamm. 2016;2016:6761050. https://doi.org/10.1155/2016/6761050.
Patterson RE, Sears DD. Metabolic effects of intermittent fasting. Annu Rev Nutr. 2017;37:371–93. https://doi.org/10.1146/annurev-nutr-071816-064634.
Poprac P, Jomova K, Simunkova M, et al. Targeting free radicals in oxidative stress-related human diseases. Trends Pharmacol Sci. 2017;38(7):592–607. https://doi.org/10.1016/j.tips.2017.04.005.
Roberfroid M, Gibson GR, Hoyles L, et al. Prebiotic effects: metabolic and health benefits. Br J Nutr. 2010;104(Suppl 2):S1–63. https://doi.org/10.1017/S0007114510003363.
Rybak A. Organic and nonorganic feeding disorders. Ann Nutr Metab. 2015;66(Suppl 5):16–22. https://doi.org/10.1159/000381373. Epub 2015 Jul 24
Saha SK, Lee SB, Won J, et al. Correlation between oxidative stress, nutrition, and cancer initiation. Int J Mol Sci. 2017;18(7):1544. https://doi.org/10.3390/ijms18071544.
Sari M, Erkorkmaz U, Yazar H, Kocayigit I, Omar B, Alizade E, Aksoy MNM, Uslu A, Cakar GC, Pala S. Dynamic thiol/disulphide homeostasis in patients with hypertrophic cardiomyopathy. Herz. 2021;46(2):164–71. https://doi.org/10.1007/s00059-019-04853-7. English. Epub 2019 Dec 9. PMID: 31820030
Sezgin B, Pirinççi F, Camuzcuoğlu A, et al. Assessment of thiol disulfide balance in early-stage endometrial cancer. J Obstet Gynaecol Res. 2020;46(7):1140–7. https://doi.org/10.1111/jog.14301.
Sharma S, Chatterjee S. Microplastic pollution, a threat to marine ecosystem and human health: a short review. Environ Sci Pollut Res Int. 2017;24(27):21530–47. https://doi.org/10.1007/s11356-017-9910-8.
Şimşek Ö, Çarlıoğlu A, Alışık M, et al. Thiol/disulfide balance in patients with familial hypercholesterolemia. Cardiol Res Pract. 2018;2018:9042461. https://doi.org/10.1155/2018/9042461.
Slyvka Y, Wang Z, Yee J, et al. Antioxidant diet, gender and age affect renal expression of nitric oxide synthases in obese diabetic rats. Nitric Oxide. 2011;24(1):50–60. https://doi.org/10.1016/j.niox.2010.11.004.
Sonmez MG, Kozanhan B, Deniz ÇD, et al. Dynamic thiol/disulfide homeostasis as a novel indicator of oxidative stress in patients with urolithiasis. Investig Clin Urol. 2019;60(4):258–66. https://doi.org/10.4111/icu.2019.60.4.258.
Temel MT, Demiryürek S, Temel L, et al. Dynamic thiol/disulfide homeostasis in children with community-acquired pneumonia. Pediatr Int. 2019;61(3):252–7. https://doi.org/10.1111/ped.13773.
Tomasello G, Mazzola M, Leone A, et al. Nutrition, oxidative stress and intestinal dysbiosis: influence of diet on gut microbiota in inflammatory bowel diseases. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016;160(4):461–6. https://doi.org/10.5507/bp.2016.052.
van Stijn MF, Ligthart-Melis GC, Boelens PG. Antioxidant enriched enteral nutrition and oxidative stress after major gastrointestinal tract surgery. World J Gastroenterol. 2008;14(45):6960–9. https://doi.org/10.3748/wjg.14.6960.
Yazar H, Yıldız E, Inci BM, et al. An analysis of plasma thiol/disulphide homeostasis in patients with stable angina. Online Turk J Health Sci. 2020;5(2):318–23. https://doi.org/10.26453/otjhs.615454.
Yüksel M, Ülfer G. Evaluation of thiol/disulfide homeostasis in patients with pityriasis rosea. Cutan Ocul Toxicol. 2019;38(4):338–43. https://doi.org/10.1080/15569527.2019.1616748.
Yuvaci HU, Akdemir N, Bostanci MS, et al. Evaluation of the level of thiol-disulphide homeostasis in patients with mild and severe preeclampsia. Pregnancy Hypertens. 2016;6(4):394–9. https://doi.org/10.1016/j.preghy.2016.09.003.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2022 Springer Nature Switzerland AG
About this entry
Cite this entry
Yazar, H., Kayacan, Y., Erel, Ö. (2022). Thiol-Disulfide Homeostasis as an Oxidative Stress Indicator. In: Patel, V.B., Preedy, V.R. (eds) Biomarkers in Nutrition . Biomarkers in Disease: Methods, Discoveries and Applications. Springer, Cham. https://doi.org/10.1007/978-3-030-81304-8_47-1
Download citation
DOI: https://doi.org/10.1007/978-3-030-81304-8_47-1
Received:
Accepted:
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-81304-8
Online ISBN: 978-3-030-81304-8
eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences