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Emerging Technologies to Increase the Bioavailability of Poorly Water-Soluble Drugs

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Formulating Poorly Water Soluble Drugs

Part of the book series: AAPS Advances in the Pharmaceutical Sciences Series ((AAPS,volume 50))

Abstract

The poor aqueous solubility and dissolution of new chemical entities (NCEs) can be the driving factor for eliminating pharmacologically superior leads. Reconsidering the chemistry of these compounds can be economically burdensome and may result in the loss of activity. Moreover, a considerable percent of drug substances in the market also face solubility issues. Solving solubility issues can improve the efficiency of the dosage forms, the efficacy of the molecules, and open possibilities for repurposing these molecules for other ailments. Novel processes and formulation-based approaches that have overcome traditional techniques’ limitations can prove to be effective and economically feasible for these high-potential leads and drug substances. The purpose of this chapter is to describe emerging technologies for solubility enhancement, allowing the reader to gain an understanding of their utility. The current authors would like to thank and acknowledge the previous authors’ significant contribution from the first and second edition. This current third edition chapter is a revision and update of the original authors’ work from the first and second editions.

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  1. Authors Daniel A. Davis Jr. and Rishi Thakkar have equally contributed to this chapter.

Authors and Affiliations

  1. Pharmaceutics Division, College of Pharmacy, University of Texas at Austin, Austin, TX, USA

    Daniel A. Davis Jr., Rishi Thakkar, Mohammed Maniruzzaman & Robert O. Williams III

  2. DisperSol Technologies, Georgetown, TX, USA

    Dave A. Miller

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  1. Daniel A. Davis Jr.
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  2. Rishi Thakkar
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Correspondence to Daniel A. Davis Jr. .

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Editors and Affiliations

  1. Division of Pharmaceutics, The University of Texas at Austin, Austin, TX, USA

    Robert O. Williams III

  2. Division of Pharmaceutics, College of Pharmacy, The University of Texas at Austin, Austin, TX, USA

    Daniel A. Davis Jr.

  3. DisperSol Technologies, LLC, Georgetown, TX, USA

    Dave A. Miller

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Davis, D.A., Thakkar, R., Maniruzzaman, M., Miller, D.A., Williams, R.O. (2022). Emerging Technologies to Increase the Bioavailability of Poorly Water-Soluble Drugs. In: Williams III, R.O., Davis Jr., D.A., Miller, D.A. (eds) Formulating Poorly Water Soluble Drugs. AAPS Advances in the Pharmaceutical Sciences Series, vol 50. Springer, Cham. https://doi.org/10.1007/978-3-030-88719-3_13

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