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Deciphering the Nexus Between Oxidative Stress and Spermatogenesis: A Compendious Overview

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Oxidative Stress and Toxicity in Reproductive Biology and Medicine

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1391))

Abstract

Oxidative stress (OS) and reactive oxygen species (ROS) are one of the main reasons for the multifactorial concern – male infertility. ROS are active components of cellular metabolism that are intrinsic to cellular functioning and are present at minimal and unreactive levels in normal cells. They are an integral component of the sperm developmental physiology, capacitation, and function. As said “anything in excess is poison,” so is the case with ROS. These, when produced in excess to the antioxidants present in the seminal plasma, cause multiple malformations during the process of spermatogenesis such as lipid peroxidation, interfere with capacitation, sperm DNA fragmentation and damage to the membrane of the sperm which in turn reduces the motility of the sperm and its ability to fuse with the oocyte. Exposure of spermatozoa to oxidative stress is a major causative agent of male infertility. Thus, a delicate balance between the beneficial and detrimental effects of ROS for proper functions is of utter importance. In this chapter, the influence of ROS in OS which is a key player in male infertility along with the diagnosis, available treatment, and prevention of extensive ROS buildup within the spermatozoa are highlighted.

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  1. Department of Biotechnology, Chaitanya Bharathi Institute of Technology, Hyderabad, Telangana, India

    Caleb Joel Raj, C. V. S. Aishwarya, K. V. S. S. N. Mounika, Bishwambhar Mishra, B. Sumithra & Sanjeeb Kumar Mandal

  2. School of Biological Sciences, Nanyang Technology University, Singapore, Singapore

    Bhushan Vishal

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  1. Department of Life Science and Bioinformatics, Assam University, Silchar, India

    Shubhadeep Roychoudhury

  2. Department of Bioproducts and Biosystems, School of Chemical Engineering, Aalto University, ESPOO, Finland

    Kavindra Kumar Kesari

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Raj, C.J. et al. (2022). Deciphering the Nexus Between Oxidative Stress and Spermatogenesis: A Compendious Overview. In: Roychoudhury, S., Kesari, K.K. (eds) Oxidative Stress and Toxicity in Reproductive Biology and Medicine. Advances in Experimental Medicine and Biology, vol 1391. Springer, Cham. https://doi.org/10.1007/978-3-031-12966-7_1

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