Abstract
This chapter deals with formulation and preparation of ear drops for application to the external auditory canal as well as those intended for the middle ear. Creams and ointments for the ear are similar to semisolid preparations for cutaneous use.
The most used ear drops prepared in pharmacies are discussed for their formulation (solvent, pH, osmotic value, preservation), method of preparation, packaging, storage and methods of administration.
The formulation of ear drops, especially the choice of the vehicle, depends on the site of action: the external auditory canal or the middle ear. When ear drops get to the middle ear, they may come into contact with the inner ear and so cause ototoxicity. Because of the ototoxicity of active substances, non-aqueous vehicles and many other excipients, special precautions are needed in formulations that should, or may accidentally, come into contact with the middle ear. Preparations intended for the middle ear are aqueous, sterile and preferably iso-osmotic. When non-aqueous vehicles are used in ear drops for the external auditory canal, it depends on the state of the patient’s ear drum whether they will reach the middle ear.
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References
Zure oordruppels met hydrocortison 1 % FNA. Jaar 2009. Formularium der Nederlandse Apothekers. Den Haag: Koninklijke Nederlandse Maatschappij ter bevordering der Pharmacie (KNMP)
Aluminium Acetate Ear Drops. British Pharmacopoeia 2014. The Stationary Office, London
Thorp MA, Kruger J, Oliver S, Nilssen EL, Prescott CA (1998) The antibacterial acidity of acetic acid and Burow’s solution as topical otological preparations. J Laryngol Otol 112:925–928
Goycoolea MV, Jung TK (1991) Complications of suppurative otitis media. In: Paparella MM, Shumrick DA, Gluckman JL, Meyerhoff WL (eds) Otolaryngology, vol 2. WB Saunders, Philadelphia, pp 1381–1403
Glassman JM, Pillar J, Soyka JP (1978) Otitis external: comparative in vitro sensitivities of clinical isolates of bacteria and fungi to nonantibiotic and antibiotic otic preparations. Curr Ther Res Clin Exp 23:S29–S38
Brook I, Finegold SM (1979) Bacteriology of chronic otitis media. JAMA 241:487–488
Burton MJ, Doree C (2009) Ear drops for the removal of ear wax. Cochrane Database Syst Rev 1:Art. No.: CD004326. https://doi.org/10.1002/14651858.CD004326.pub2. Accessed 15 Mar 2013
Farmacotherapeutisch Kompas. Aandoeningen van de uitwendige gehoorgang www.fk.cvz.nl. Accessed 15 Mar 2013
Ă–lige Clotrimazol-Ohrentropfen 1% NRF 16.4. Fassung 2010. Neues Rezeptur-Formularium. GOVI-Verlag Pharmazeutischer Verlag GMBH, Eschborn. Deutscher Apotheker-Verlag, Stuttgart
Dohar J (2004) Eardrops for Otorrhoea. In: Alper CM, Bluestone C, Dohar JE, Mandel EM, Casselbrant ML (eds) Advanced therapy of otitis media. BC Decker Publications, Hamilton, pp 246–253
Swan EEL, Mescher MJ, Sewell WF, Toa SL, Borenstein JT (2008) Inner ear drug delivery for auditory applications. Adv Drug Deliv Rev 60:1583–1599
Richardson RT, Wise AK, Andrew JK, O’Leary SJ (2008) Novel drug delivery systems for inner ear protection and regeneration after hearing loss. Expert Opin Drug Deliv 5:1059–1076
Haynes DS, Rutka J, Hawke M, Roland PS (2007) Ototoxicity of ototopical drops – an update. Otolaryngol Clin N Am 40:669–683
Goycoolea MV (2001) Clinical aspects of round window permeability under normal and pathological conditions. Acta Otolaryngol (Stockh) 121:437–447
Goycoolea MV, Muchow D, Schachern PA (1988) Experimental studies on round window membrane structure function and permeability. Laryngoscope 98(Suppl. 44):1–20
Guthrie OW (2008) Aminoglycoside induced toxicity. Toxicology 249:91–96
Munguia R, Daniel SJ (2008) Ototopical antifungals and otomycosis: a review. Int J Pediatr Otorhinolaryngol 72:453–459
Van der Hulst RJAM (2001) Ototoxiciteit van oordruppels. Het standpunt van de KNO-vereniging. Pharm Weekbl 136:495–497
Miconazol oordruppels 2% FNA. Jaar 2009. Formularium der Nederlandse Apothekers. Den Haag: Koninklijke Nederlandse Maatschappij ter bevordering der Pharmacie (KNMP)
The normal microbial flora of the outer ear canal in healthy Norwegian individuals W L Dibb. https://pubmed.ncbi.nlm.nih.gov/221604/
Kim JK, Cho JH (2009) Change of external auditory canal pH in acute otitis externa. Ann Otol Rhinol Laryngol 118(11):769–772
Horikx A (2005) Boorzuur in oogdruppels ook beneden 3 jaar. Pharm Weekbl 140:82
Aluminiumacetotartraatoordruppels 12% FNA. Jaar 2009. Formularium der Nederlandse Apothekers. Den Haag: Koninklijke Nederlandse Maatschappij ter bevordering der Pharmacie (KNMP)
Aluminiumacetotartraatoordruppels 1,2% FNA. Jaar 2009. Formularium der Nederlandse Apothekers. Den Haag: Koninklijke Nederlandse Maatschappij ter bevordering der Pharmacie (KNMP)
Efficacy of Boric Acid as a Treatment of Choice for Chronic Suppurative Otitis Media and Its Ototoxicity Indri Adriztina, Linda Irwani Adenin, and Yuliani Mardiati Lubis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788841/
Citric Acid as an Alternative to Boric Acid in the Treatment of Chronic Suppurative Otitis Media Basavraj Nagoba* and Milind Davane https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669388/
Role of Clotrimazole in Prevention of Recurrent Otomycosis Keyvan Kiakojuri, 1 Ramazan Rajabnia, 2 , 3 Saeid Mahdavi Omran, 2 , 4 Abazar Pournajaf, 2, 3 Mohsen Karami, 4 and Mojtaba Taghizadeh Armaki 2, 4 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944967/
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Gantumur, M., Russell, C. (2023). Ear. In: Le Brun, P., Crauste-Manciet, S., Krämer, I., Smith, J., Woerdenbag, H. (eds) Practical Pharmaceutics. Springer, Cham. https://doi.org/10.1007/978-3-031-20298-8_17
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