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Galanin in Glia: Expression and Potential Roles in the CNS

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Galanin

Part of the book series: Experientia Supplementum ((EXS,volume 102))

Abstract

The roles of galanin in central nervous system (CNS) development and the normal adult CNS have been extensively reviewed in this volume and elsewhere. There is also ample evidence that galanin expression is induced following neural injury in the CNS, and has neuroprotective properties separate from its role in normal physiology. Although strong injury-mediated up-regulation of galanin occurs in neurons, there is increasing evidence, accumulated over almost two decades, that glial cells can express galanin in the injured brain and during white matter development. In this chapter, we review the available evidence and canvas the potential functional significance of glial galanin expression.

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Acknowledgements

The authors would like to acknowledge the support of NHMRC (Australia) and the US Multiple Sclerosis Society and the many colleagues who contributed to the research reviewed in this article.

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Authors and Affiliations

  1. Florey Neuroscience Institutes, The University of Melbourne, Melbourne, VIC, 3010, Australia

    Helmut Butzkueven & Andrew L. Gundlach

  2. Department of Medicine, The University of Melbourne, Melbourne, VIC, 3010, Australia

    Helmut Butzkueven

  3. Department of Anatomy and Cell Biology, The University of Melbourne, Melbourne, VIC, 3010, Australia

    Andrew L. Gundlach

Authors
  1. Helmut Butzkueven
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  2. Andrew L. Gundlach
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Corresponding author

Correspondence to Andrew L. Gundlach .

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Editors and Affiliations

  1. Dept. Neuroscience, Karolinska Institute, Retzius vaeg 8, Stockholm, 171 77, Sweden

    Tomas Hökfelt

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© 2010 Springer Basel AG

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Butzkueven, H., Gundlach, A.L. (2010). Galanin in Glia: Expression and Potential Roles in the CNS. In: Hökfelt, T. (eds) Galanin. Experientia Supplementum, vol 102. Springer, Basel. https://doi.org/10.1007/978-3-0346-0228-0_6

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