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Survival, growth and function of damaged cholinergic neurons

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Central Cholinergic Synaptic Transmission

Part of the book series: Experientia Supplementum ((EXS,volume 57))

Summary

Recent progress has been made in defining the requirements for survival, growth and function of damaged cholinergic neurons of the central nervous system. In particular, the responsiveness of cholinergic neurons to nerve growth factor (NGF) in the regulation of development, cell survival, axon elongation, and response to injury has led to the formulation of the Neurotrophic Hypothesis, a unifying hypothesis of neuronal responsiveness to growth-promoting substances. NGF-mediated effects on cholinergic neurons in culture as well as in the septum, basal nucleus, striatum, and hippocampus, and the ability of NGF to prevent lesion-induced cell death and to ameliorate the effects of aging, provide the foundation for this work. A potential role for glia and microglia in mediating the effects of NGF is proposed.

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Authors and Affiliations

  1. Department of Neurosciences M-024, University of California at San Diego, La Jolla, CA, 92093, USA

    Fred H. Gage, Mark H. Tuszynski, Karen S. Chen, David Armstrong & György Buzsàki

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  1. Fred H. Gage
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  2. Mark H. Tuszynski
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  3. Karen S. Chen
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  4. David Armstrong
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  5. György Buzsàki
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Editors and Affiliations

  1. Anatomisches Institut, J.W. Goethe-Universität, Theodor-Stern-Kai 7, 6000, Frankurt a.M 70, Federal Republic of Germany

    Michael Frotscher

  2. Max-Planck-Institut für Psychiatrie, Am Klopferspitz 18A, 8033, Planegg-Martinsried, Federal Republic of Germany

    Ulrich Misgeld

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Gage, F.H., Tuszynski, M.H., Chen, K.S., Armstrong, D., Buzsàki, G. (1989). Survival, growth and function of damaged cholinergic neurons. In: Frotscher, M., Misgeld, U. (eds) Central Cholinergic Synaptic Transmission. Experientia Supplementum, vol 57. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9138-7_26

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  • DOI: https://doi.org/10.1007/978-3-0348-9138-7_26

  • Publisher Name: Birkhäuser Basel

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