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The Synthesis of Platinum(II) Intercalators

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Metallointercalators

Abstract

The pharmacological properties of any drug are largely dependent on binding interactions with biomolecules. The investigation of such interactions is essential to gain some understanding of the mechanisms of drug action, and to determine which structural characteristics influence the pharmacological properties. Of particular interest are the interactions between anticancer agents and DNA, as DNA is considered to be the major cellular target for a large number of compounds that are effective in the treatment of various types of cancers [1–11].

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Acknowledgements

The authors would like to thank the Australian Government for the international Science Linkage Grant and University of Western Sydney for financial support through internal research grants. A.M.K-H and K. B. G.-S. were supported by Australian Postgraduate Awards from the University of Western Sydney. We wish to thank S. Ralph for useful discussions and editorial comments.

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  1. School of Biomedical & Health Sciences, University of Western Sydney, Penrith South DC, New South Wales, Sydney, Australia

    Janice Aldrich-Wright

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  1. Anwen M. Krause-Heuer
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  2. Madhura Manohar
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  3. K. Benjamin Garbutcheon-Singh
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  4. Dianne M. Fisher
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Krause-Heuer, A.M., Manohar, M., Garbutcheon-Singh, K.B., Fisher, D.M., Aldrich-Wright, J. (2011). The Synthesis of Platinum(II) Intercalators. In: Aldrich-Wright, J. (eds) Metallointercalators. Springer, Vienna. https://doi.org/10.1007/978-3-211-99079-7_3

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