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Bacterial Activation of Type I Interferons pp 1–15Cite as

Production and Action of Type I Interferons in Host Defense

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Summary

In this chapter, the Type I interferons (IFNs), their modes of production, signaling, regulation of sets of effector genes and their roles in host defense will be introduced. During infection by bacteria and other pathogens, a fine balance in the IFN response is required to ensure protection of the host and the avoidance of toxicity or chronic disease. The pattern recognition receptors (PRRs) involved in inducing the interferon response; the Type I interferon receptors and their downstream signal transduction pathways; the interferon-regulated genes; and the Type I interferon regulated immune and antibacterial responses will be discussed. Case studies of IFNβ and IFNε will be presented as examples of broader principles of how regulating IFN expression in particular ways, organ specific requirements and compartmentalization within an organ can yield different results for host defense. The broad impact of the Type I interferon response to infections with bacterial pathogens including Escherichia coli, Salmonella species, Helicobacter pylori, Staphylococcus aureus, group A and B streptococci, Listeria monocytogenes, Mycobacterium tuberculosis, Chlamydia species and Legionella pneumophilia will be highlighted.

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  1. Centre for Innate Immunity and Infectious Diseases, MIMR-PHI Institute, Monash University, Clayton, VIC, Australia

    Paul J. Hertzog

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    Dane Parker

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Hertzog, P.J. (2014). Production and Action of Type I Interferons in Host Defense. In: Parker, D. (eds) Bacterial Activation of Type I Interferons. Springer, Cham. https://doi.org/10.1007/978-3-319-09498-4_1

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