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Nicotine Withdrawal

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The Neuropharmacology of Nicotine Dependence

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 24))

Abstract

An aversive abstinence syndrome manifests 4–24 h following cessation of chronic use of nicotine-containing products. Symptoms peak on approximately the 3rd day and taper off over the course of the following 3–4 weeks. While the severity of withdrawal symptoms is largely determined by how nicotine is consumed, certain short nucleotide polymorphisms (SNPs ) have been shown to predispose individuals to consume larger amounts of nicotine more frequently—as well as to more severe symptoms of withdrawal when trying to quit. Additionally, rodent behavioral models and transgenic mouse models have revealed that specific nicotinic acetylcholine receptor (nAChR) subunits, cellular components, and neuronal circuits are critical to the expression of withdrawal symptoms. Consequently, by continuing to map neuronal circuits and nAChR subpopulations that underlie the nicotine withdrawal syndrome—and by continuing to enumerate genes that predispose carriers to nicotine addiction and exacerbated withdrawal symptoms—it will be possible to pursue personalized therapeutics that more effectively treat nicotine addiction.

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Acknowledgments

Funding: This work was supported in part by the following NIH grants: DA024385, U19CA148127 (MDB); DA036572 (JAD & MDB) and DA009411 (JAD).

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Authors and Affiliations

  1. Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA

    Ian McLaughlin & Mariella De Biasi

  2. Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA

    John A. Dani & Mariella De Biasi

  3. Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA

    John A. Dani & Mariella De Biasi

  4. Neuroscience Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA

    Ian McLaughlin

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  1. Ian McLaughlin
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Correspondence to Mariella De Biasi .

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  1. Ninewells Hospital, University of Dundee Medical School, Dundee, United Kingdom

    David J.K. Balfour

  2. School of Experimental Psychology, University of Bristol, Bristol, United Kingdom

    Marcus R. Munafò

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McLaughlin, I., Dani, J.A., De Biasi, M. (2015). Nicotine Withdrawal. In: Balfour, D., Munafò, M. (eds) The Neuropharmacology of Nicotine Dependence. Current Topics in Behavioral Neurosciences, vol 24. Springer, Cham. https://doi.org/10.1007/978-3-319-13482-6_4

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