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Aetiology of Oral Cavity Cancer

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Contemporary Oral Oncology

Abstract

Oral cancer is a serious and growing health problem in many parts of the globe. Most head and neck cancers are squamous cell carcinomas, and the majority are oral squamous cell carcinoma (OSCC) [1, 2]. The origin of OSCC is oral keratinocytes, and it is caused, as any other cancer, by DNA mutations which may be spontaneous but increased by exposure to a range of mutagens that could be chemical, physical or microbial. Cells with genetic mutations can progress from normal cells to pre-malignant or potentially malignant cells that have the ability to proliferate in a less-controlled fashion than normal [2]. Consequently, the cells become autonomous and cancer results.

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Acknowledgements

CSF wishes to acknowledge the contributions of members, past and present, of the Oral Oncology Research Program, UQ Centre for Clinical Research for their contribution to research undertaken into oral cancer aetiology, epidemiology and carcinogenesis.

Conflict of Interest Statement

The authors declare that they have no personal or financial conflicts of interest to declare in relation to the work presented in this chapter.

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Authors and Affiliations

  1. Australian Centre for Oral Oncology Research & Education (ACORE), School of Dentistry, University of Western Australia, Nedlands, WA, 6009, Australia

    Camile S. Farah, Maryam Jessri & Sean Currie

  2. Melbourne Dental School, University of Melbourne, Carlton, VIC, 3000, Australia

    Ali Alnuaimi, Tami Yap & Michael J. McCullough

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  1. Camile S. Farah
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Correspondence to Camile S. Farah .

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  1. Department of Head and Neck, Plastic and Reconstructive Surgery, Roswell Park Cancer Institute, Buffalo, USA

    Moni Abraham Kuriakose

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Farah, C.S., Jessri, M., Currie, S., Alnuaimi, A., Yap, T., McCullough, M.J. (2017). Aetiology of Oral Cavity Cancer. In: Kuriakose, M.A. (eds) Contemporary Oral Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-14911-0_2

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