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The Respiratory System

  • Chapter
Keeling’s Fetal and Neonatal Pathology

Abstract

The respiratory system comprises the lips and palate, larynx, trachea, lungs, and diaphragm, and their development and abnormalities of development are described. Pulmonary cystic disease forms one such group of developmental abnormalities and includes congenital lobar emphysema, congenital pulmonary adenomatoid malformation (CPAM), and pulmonary sequestration. Maturation of the lung can be terminated if delivery occurs early, leading to respiratory distress clinically, which has been ameliorated by antenatal steroids and antioxidants and postdelivery surfactant therapy. The causes and pathology of respiratory distress in the newborn are described; these include hyaline membrane disease and meconium aspiration syndrome, as well as rarer entities such as surfactant protein deficiency and alveolar capillary dysplasia. The clinical and pathology characteristics of chronic lung disease have changed over the last 20 years, and bronchopulmonary dysplasia, “old” and “new,” are described.

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Authors and Affiliations

  1. Department of Pathology, University of Adelaide, North Adelaide, SA, Australia

    T. Yee Khong MBChB, MSc, MD, FRCPath, FRCPA

  2. Department of Obstetrics and Gynaecology, University of Adelaide, North Adelaide, SA, Australia

    T. Yee Khong MBChB, MSc, MD, FRCPath, FRCPA

  3. Department of Histopathology, Women’s & Children’s Hospital, 72 King William Road, North Adelaide, SA, 5006, Australia

    T. Yee Khong MBChB, MSc, MD, FRCPath, FRCPA

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  1. T. Yee Khong MBChB, MSc, MD, FRCPath, FRCPA
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Correspondence to T. Yee Khong MBChB, MSc, MD, FRCPath, FRCPA .

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Editors and Affiliations

  1. Department of Pathology Department of Obstetrics and Gynaecology, University of Adelaide, North Adelaide, South Australia, Australia

    T. Yee Khong

  2. Department of Histopathology, Women’s & Children’s Hospital, North Adelaide, South Australia, Australia

    T. Yee Khong

  3. Department of Histopathology, University Hospitals of Leicester NHS Trust Leicester Royal Infirmary, Leicester, UK

    Roger D. G. Malcomson

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Khong, T.Y. (2015). The Respiratory System. In: Khong, T.Y., Malcomson, R.D.G. (eds) Keeling’s Fetal and Neonatal Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-19207-9_20

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  • DOI: https://doi.org/10.1007/978-3-319-19207-9_20

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-19206-2

  • Online ISBN: 978-3-319-19207-9

  • eBook Packages: MedicineMedicine (R0)

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